2011
DOI: 10.1007/s00540-011-1258-5
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Effects of neostigmine on bronchoconstriction with continuous electrical stimulation in rats

Abstract: Methods. Fifty-seven male Wistar rats were used. In in vitro study we examined whether tetrodotoxin (TTX), a Na + channel blocker, 4-DAMP, a muscarinic M 3 receptor antagonist, or neostigmine could affect c-EFS-induced contraction of the tracheal ring. In in vivo study, we examined whether c-ES of vagal nerve could increase maximum airway pressure (Pmax), and neostigmine could potentiate c-ES-induced Pmax. Results. TTX and 4-DAMP completely inhibited c-EFS-inducedcontraction, while neostigmine potentiated c-EF… Show more

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“…Moreover, the differences in pharmacology between sugammadex and neostigmine may also explain their different influences on PPCs. High-dose neostigmine may cause bronchospasm (Hazizaj & Hatija, 2006 ; Ishii et al, 2012 ), which may therefore adversely affect the pulmonary ventilation of the patients. Additionally, neostigmine administration after adequate reversal of NMB could lead to functional disorders of the genioglossus muscle and diaphragm, which may cause obstruction of the upper airway and respiratory failure (Eikermann et al, 2008 ).…”
Section: Discussionmentioning
confidence: 99%
“…Moreover, the differences in pharmacology between sugammadex and neostigmine may also explain their different influences on PPCs. High-dose neostigmine may cause bronchospasm (Hazizaj & Hatija, 2006 ; Ishii et al, 2012 ), which may therefore adversely affect the pulmonary ventilation of the patients. Additionally, neostigmine administration after adequate reversal of NMB could lead to functional disorders of the genioglossus muscle and diaphragm, which may cause obstruction of the upper airway and respiratory failure (Eikermann et al, 2008 ).…”
Section: Discussionmentioning
confidence: 99%