Effects of Neural Crest-Derived Multipotent Stem Cells on Regeneration of an Injured Peripheral Nerve in Mice

Vasyliev, Roman; Rodnichenko, A. E.; Shamalo, S.; Demidchouk, A. S.; Labunets, I. F.; Chaikovskii, Yu. B.; Butenko, G. M.

doi:10.1007/s11062-015-9501-6

Cited by 11 publications

(10 citation statements)

References 4 publications

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“…Although the underlying mechanisms for regeneration of the injured peripheral nerves remain unclear, NCSCs can be used as a promising stem cell type for peripheral nerve repair. This finding is supported by a study of Vasyliev et al [44], which reported that after implantation of neural crest-derived multipotent stem cells into the transected region of mice, the intensity of nerve regeneration in this injured region was increased compared with that in mice without transplantation. This work indicated that NCSCs possess a pronounced biological property to promote nerve repair by differentiating into Schwann cells that are indispensable in peripheral nerve regeneration, as Schwann cells not only provide a support for axon migration but also secrete neurotrophic factors to promote nerve growth [42, 45].…”

Section: Clinical Applications Of Ncscssupporting

confidence: 66%

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Prospect of Human Pluripotent Stem Cell‐Derived Neural Crest Stem Cells in Clinical Application

Zhu

Gao

et al. 2016

Stem Cells International

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Neural crest stem cells (NCSCs) represent a transient and multipotent cell population that contributes to numerous anatomical structures such as peripheral nervous system, teeth, and cornea. NCSC maldevelopment is related to various human diseases including pigmentation abnormalities, disorders affecting autonomic nervous system, and malformations of teeth, eyes, and hearts. As human pluripotent stem cells including human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSCs) can serve as an unlimited cell source to generate NCSCs, hESC/hiPSC-derived NCSCs can be a valuable tool to study the underlying mechanisms of NCSC-associated diseases, which paves the way for future therapies for these abnormalities. In addition, hESC/hiPSC-derived NCSCs with the capability of differentiating to various cell types are highly promising for clinical organ repair and regeneration. In this review, we first discuss NCSC generation methods from human pluripotent stem cells and differentiation mechanism of NCSCs. Then we focus on the clinical application potential of hESC/hiPSC-derived NCSCs on peripheral nerve injuries, corneal blindness, tooth regeneration, pathological melanogenesis, Hirschsprung disease, and cardiac repair and regeneration.

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Section: Clinical Applications Of Ncscssupporting

confidence: 66%

“…Therefore, there is a need to improve the clinical outcomes of peripheral nerve repair. Stem cell-based therapies with tissue-engineered scaffolds are now being developed to accelerate the regeneration of peripheral nerve injuries [43, 44]. …”

Section: Clinical Applications Of Ncscsmentioning

confidence: 99%

Prospect of Human Pluripotent Stem Cell‐Derived Neural Crest Stem Cells in Clinical Application

Zhu

Gao

et al. 2016

Stem Cells International

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“…Волосяний фолікул складається із концентрично розташованих циліндрів, що містять клітини, які продукують високоспеціалізовані протеїни, зокрема кератин, основний компонент волосся і перебуває у постійному динамічному стані: фаза росту (анаген), перехідна фаза (катаген), фаза спокою (телоген) [136]. Такий активний життєвий цикл передбачає наявність стовбурових клітин [137].…”

Section: джерела і види стовбурових клітин для відновлення периферичнunclassified

Stem Cell Technology in Peripheral Nerve Restoration

Petriv

Tsymbalyuk

Potapov

et al. 2020

EUMJ

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Peripheral nerve injuries are a significant problem in the medical and socio-economic plan, as they are accompanied by a high incidence of disability by people of working age. In recent decades, significant progress has been made in the restorative surgery of the peripheral nervous system, in particular through the introduction into clinical practice of microsurgical techniques. However, the problem of restoring the peripheral nerve after its traumatic injury has not been resolved yet. A review article addresses the current state of developing stem cell technologies for peripheral nerve repair. Basic concepts of peripheral nerve regeneration after traumatic injury, methods of their restoration in experimental and clinic conditions are considered. The prospect of using stem cells of different origins is shown in the experiment by many authors, and the positive effect of stem cells on peripheral nerve regeneration is explained by their ability to secrete many trophic factors and differentiation to a neural phenotype. An essential issue in the tissue engineering approach is the choice of the optimal material to be used as a scaffold for large size peripheral nerve defects grafting. The article focuses on the main types of stem cells, as well as their combinations with biopolymers, which have shown efficiency in the experiment. Despite the advances in the use of the latest technologies, the search for the necessary components is underway to provide the most favorable conditions for peripheral nerve regeneration in the clinic.

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“…СКНГ дають початок нестин-позитивним стовбуровим клітинам строми кісткового мозку [18]. Зважаючи на нейро-генний, гліальний (нейролемоцити, що продукують ПН) потенціал СКНГ, їх використання у відновному лікуванні ушкоджених ПН є перспективним [19,20]. З практичної точки зору доцільним є використання не власне СКНГ, що є в ембріона, а постнатальних МСК-ПНГ, що містяться у тканинах дорослого ор-ганізму.…”

Section: Abstract: Peripheral Nerve Injury; Autoneuroplasty; Tissue Eunclassified

“…Сьогодні доведено, що МСК-ПНГ, виділені з волосяного мішечка, можуть диференціюватися у нейрони, гліальні клітини, ос-теобласти, гладеньком`язові клітини, меланоцити in vitro [20,23] та демонструють цей мультилінійний по-тенціал на клональному рівні [24]. Нестин-позитивні, кератин 15-негативні клітини можуть диференціюва-тися у нейрони при їх підшкірній імплантації білими мишам [22].…”

Section: Abstract: Peripheral Nerve Injury; Autoneuroplasty; Tissue Eunclassified

Efficiency of peripheral nerve gaps restoration by different types of tissue engineering constructs according to electromyography: experimental study

Tsymbalyuk¹,

Petriv²,

Medvediev³

et al. 2017

Ukr Neurosurg J

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Effects of Neural Crest-Derived Multipotent Stem Cells on Regeneration of an Injured Peripheral Nerve in Mice

Cited by 11 publications

References 4 publications

Prospect of Human Pluripotent Stem Cell‐Derived Neural Crest Stem Cells in Clinical Application

Prospect of Human Pluripotent Stem Cell‐Derived Neural Crest Stem Cells in Clinical Application

Stem Cell Technology in Peripheral Nerve Restoration

Efficiency of peripheral nerve gaps restoration by different types of tissue engineering constructs according to electromyography: experimental study

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