Effects of neuropeptide Y on the microvasculature of human skeletal muscle

Mirman, Benjamin; Ikeda, Ian; Zhang, Zhiqi; Liu, Yuhong; Yu, Lu; Ehsan, Afshin; Feng, Jun; Sellke, Frank W.

doi:10.1016/j.surg.2020.04.020

Cited by 9 publications

(9 citation statements)

References 19 publications

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“…It was further hypothesized that this may be related to microvascular changes and altered regulation of perfusion that occurs in the brain and other organs during and after cardiac surgery. [17][18][19][20] Marked alterations in vasomotor regulation have been documented after cardiac surgery utilizing cardiopulmonary bypass both in vivo 21 and in vitro. [17][18][19][20]22,23 These changes in vasomotor regulation and other cellular signaling are exacerbated or different in patients with poorly controlled diabetes compared to patients without diabetes or well controlled diabetes.…”

Section: Discussionmentioning

confidence: 99%

“…[17][18][19][20] Marked alterations in vasomotor regulation have been documented after cardiac surgery utilizing cardiopulmonary bypass both in vivo 21 and in vitro. [17][18][19][20]22,23 These changes in vasomotor regulation and other cellular signaling are exacerbated or different in patients with poorly controlled diabetes compared to patients without diabetes or well controlled diabetes. [22][23][24][25] While hyperglycemia is often seen as an inflammatory state and therefore theorized to be associated with inflammatory markers penetrating the blood-brain barrier and causing decreased neurocognitive function, we did not observe that in this study.…”

Section: Discussionmentioning

confidence: 99%

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Inflammation but not Glycemic Control is Associated with Neurocognitive Decline After Cardiac Surgery

Scrimgeour

Ikeda

Sellke

et al. 2021

Preprint

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Background: Whether perioperative glycemic control or markers of inflammation is associated with neurocognitive decline (NCD) after cardiac surgery was examined. Methods: Thirty patients undergoing cardiac surgery utilizing cardiopulmonary bypass (CPB) were screened for NCD preoperatively and on post-operative day four (POD4). Serum cytokine levels were measured and human transcriptome analysis was performed on blood samples. Neurocognitive data are presented as a change from baseline to POD4 in a score standardized with respect to age and gender. Results: A decline in neurocognitive function was identified in 73% (22/30) of patients on POD4. Patients with postoperative leukocytosis (WBC ≥ 10.5) had more NCD when compared to their baseline function (p=0.03). Patients with elevated IL-8 levels at 6 hours postoperatively had a significant decline in NCD at POD4 (p=0.04). Surprisingly, TNF-α, IL-1β, IL-2, or IL-6 levels were not associated with NCD (p>0.3 for all). There was no difference in neurocognitive function between patients with elevated HbA1c levels preoperatively (p=0.973) or elevated fasting blood glucose levels the morning of surgery (>126mg/dL, p=0.910), or a higher maximum blood glucose levels during CPB (>180mg/dL, p=0.252), or higher average glucose levels during CPB (>160mg/dL, p=0.639). Human transcriptome analysis demonstrated unique and differential patterns of gene expression in patients depending on the presence of DM and NCD. Conclusions: Perioperative glycemic control does not have an effect on NCD soon after cardiac surgery. Postoperative leukocytosis and elevated IL-8 levels are associated with neurocognitive decline. The profile of gene expression was altered in patients with NCD with or without diabetes.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Inflammation but not Glycemic Control is Associated with Neurocognitive Decline After Cardiac Surgery

Scrimgeour

Ikeda

Sellke

et al. 2021

Preprint

Self Cite

View full text Add to dashboard Cite

show abstract

“…It was further hypothesized that this may be related to microvascular changes and altered regulation of perfusion that occurs in the brain and other organs during and after cardiac surgery. [19][20][21][22] Marked alterations in vasomotor regulation have been documented after cardiac surgery utilizing CPB both in vivo 23 and in vitro. [19][20][21][22]24,25 These changes in vasomotor regulation and other cellular signaling are exacerbated or different in patients with poorly controlled diabetes compared to patients without diabetes or well controlled diabetes.…”

Section: Discussionmentioning

confidence: 99%

Glycemic control is not associated with neurocognitive decline after cardiac surgery

Scrimgeour

Ikeda

Sellke

et al. 2021

Journal of Cardiac Surgery

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Background: Whether perioperative glycemic control is associated with neurocognitive decline (NCD) after cardiac surgery was examined.Methods: Thirty patients undergoing cardiac surgery utilizing cardiopulmonary bypass (CPB) were screened for NCD preoperatively and on postoperative day 4 (POD4). Indices of glucose control were examined. Serum cytokine levels were measured and human transcriptome analysis was performed on blood samples.Neurocognitive data are presented as a change from baseline to POD4 in a score standardized with respect to age and gender.Results: A decline in neurocognitive function was identified in 73% (22/30) of patients on POD4. There was no difference in neurocognitive function between patients with elevated HbA1c levels preoperatively (p = .973) or elevated fasting blood glucose levels the morning of surgery (>126 mg/dl, p = .910), or a higher maximum blood glucose levels during CPB (>180 mg/dl, p = .252), or higher average glucose levels during CPB (>160 mg/ dl, p = .639). Patients with postoperative leukocytosis (WBC ≥ 10.5) had more NCD when compared to their baseline function (p = .03). Patients with elevated IL-8 levels at 6 h postoperatively had a significant decline in NCD at POD4 (p = .04). Human transcriptome analysis demonstrated unique and differential patterns of gene expression in patients depending on the presence of DM and NCD.Conclusions: Perioperative glycemic control does not have an effect on NCD soon after cardiac surgery. The profile of gene expression was altered in patients with NCD with or without diabetes.

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“…It is generally accepted that nicotine enhances vasoconstriction by disrupting the balance between vasoconstrictors (such as NA) and vasodilators (such as NO), especially in coronary arteries with endothelial damage (63). As demonstrated, nicotine elevates the level of plasma NPY, both NPY and NA are powerful vasoconstrictors (64)(65)(66)(67). There seems to be a consensus that NPY and NA are stored together in presynaptic vesicles and in large, dense-core vesicles.…”

Section: Npy Nicotine and Vasoconstrictionmentioning

confidence: 99%

Updated Role of Neuropeptide Y in Nicotine-Induced Endothelial Dysfunction and Atherosclerosis

Yanli

Wang

et al. 2021

Front. Cardiovasc. Med.

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Cardiovascular disease is the leading cause of death worldwide. Endothelial dysfunction of the arterial vasculature plays a pivotal role in cardiovascular pathogenesis. Nicotine-induced endothelial dysfunction substantially contributes to the development of arteriosclerotic cardiovascular disease. Nicotine promotes oxidative inflammation, thrombosis, pathological angiogenesis, and vasoconstriction, and induces insulin resistance. However, the exact mechanism through which nicotine induces endothelial dysfunction remains unclear. Neuropeptide Y (NPY) is widely distributed in the central nervous system and peripheral tissues, and it participates in the pathogenesis of atherosclerosis by regulating vasoconstriction, energy metabolism, local plaque inflammatory response, activation and aggregation of platelets, and stress and anxiety-related emotion. Nicotine can increase the expression of NPY, suggesting that NPY is involved in nicotine-induced endothelial dysfunction. Herein, we present an updated review of the possible mechanisms of nicotine-induced atherosclerosis, with a focus on endothelial cell dysfunction associated with nicotine and NPY.

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Effects of neuropeptide Y on the microvasculature of human skeletal muscle

Cited by 9 publications

References 19 publications

Inflammation but not Glycemic Control is Associated with Neurocognitive Decline After Cardiac Surgery

Inflammation but not Glycemic Control is Associated with Neurocognitive Decline After Cardiac Surgery

Glycemic control is not associated with neurocognitive decline after cardiac surgery

Updated Role of Neuropeptide Y in Nicotine-Induced Endothelial Dysfunction and Atherosclerosis

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