Effects of neuropeptides on feeding initiation in larvae of the silkworm, Bombyx mori

Nagata, Shinji; Morooka, Nobukatsu; Matsumoto, Sumihiro; Kawai, Takeshi; Nagasawa, Hiromichi

doi:10.1016/j.ygcen.2011.03.004

Cited by 45 publications

(64 citation statements)

References 32 publications

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“…In this animal, the injection of Bom-sNPF-2 was shown to decrease the latency of feeding. This effect could however not be demonstrated for Bom-sNPF-1 and -3 (Nagata et al 2011). These observations suggest that sNPF positively regulates food search and feeding in these insect species.…”

Section: Neuropeptide F and Short Neuropeptide Fmentioning

confidence: 75%

“…They are able to inhibit contractions of heart and skeletal muscles (Robb and Evans 1994), oviduct (Peeff et al 1994), foregut (Banner and Osborne 1989), midgut (Lange and Orchard 1998), and salivary glands (Orchard and Te Brugge 2002). They also modulate the release of digestive enzymes (Harshini et al 2002;Schoofs and Nachman 2006) and influence feeding behavior (Wei et al 2000;Nagata et al 2011). The FaLPs are distributed over the central and peripheral nervous system and may perform diverse roles as neurohormones, neuromodulators, or endocrine factors acting on the gut (Tsang and Orchard 1991).…”

Section: Fmrfamide-like Peptidesmentioning

confidence: 99%

“…After injection of myosuppressin, B. mori larvae showed a dose-dependent delay in the initiation of feeding. The delay is probably caused by a decrease in contractile activity of the gut (Nagata et al 2011). Larvae of the African cotton leafworm (Spodoptera littoralis Boisduval, 1833) that were injected with myosuppressin stopped feeding after 3 h, whereas control larvae kept feeding, leading to lower total leaf consumption and illustrating a significant antifeeding activity of myosuppressin (Vilaplana et al 2008).…”

Section: Fmrfamide-like Peptidesmentioning

confidence: 99%

“…It was subsequently immunolocalized in the central and peripheral nervous system of various other arthropod species (Orchard et al 1989;Konopińska and Rosiński 1999), although some authors suggest that the proctolin signaling system may be absent in lepidopteran insects (Nagata et al 2011;Roller et al 2008). A detailed localization study in L. migratoria showed that proctolin-like immunoreactive material is present throughout the central, peripheral and stomatogastric nervous system, the retrocerebral complex as well as in processes associated with the gut muscles.…”

Section: Proctolinmentioning

confidence: 99%

“…Interestingly, injection of the synthetic peptide significantly increased food intake in adult females . In addition, a study in B. mori larvae demonstrated that synthetic tachykinin shortened the period of latency to feeding after a period of starvation (Nagata et al 2011). These observations are indeed indicative of a stimulatory role for the insect TK/TRPs in food intake.…”

Section: Tachykinin-related Peptidesmentioning

confidence: 99%

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Peptidergic control of food intake and digestion in insects¹This review is part of a virtual symposium on recent advances in understanding a variety of complex regulatory processes in insect physiology and endocrinology, including development, metabolism, cold hardiness, food intake and digestion, and diuresis, through the use of omics technologies in the postgenomic era.

et al. 2012

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Like all heterotrophic organisms, insects require a strict control of food intake and efficient digestion of food into nutrients to maintain homeostasis and to fulfill physiological tasks. Feeding and digestion are steered by both external and internal signals that are transduced by a multitude of regulatory factors, delivered either by neurons innervating the gut or mouthparts, or by midgut endocrine cells. The present review gives an overview of peptide regulators known to control feeding and digestion in insects. We describe the discovery and functional role in these processes for insect allatoregulatory peptides, diuretic hormones, FMRFamide-related peptides, (short) neuropeptide F, proctolin, saliva production stimulating peptides, kinins, and tachykinins. These peptides control either gut myoactivity, food intake, and (or) release of digestive enzymes. Some peptides exert their action at multiple levels, possibly having a biological function that depends on their site of delivery. Many regulatory peptides have been physically extracted from different insect species. However, multiple peptidomics, proteomics, transcriptomics, and genome sequencing projects have led to increased discovery and prediction of peptide (precursor) and receptor sequences. In combination with physiological experiments, these large-scale projects have already led to important steps forward in unraveling the physiology of feeding and digestion in insects.Key words: insect, midgut, digestion, neuropeptides, stomatogastric nervous system. Résumé : Comme tous les organismes hétérotrophes, les insectes requièrent un contrôle strict de leur ingestion de nourriture et la digestion de leur nourriture en nutriments afin de maintenir leur homéostasie et de compléter leurs tâches physiologiques. L'alimentation et la digestion sont gouvernées par des signaux tant externes qu'internes qui sont transmis par un multitude de facteurs régulateurs, livrés ou bien par les neurones qui innervent le tube digestif ou les pièces buccales ou alors par les cellules endocrines du tube digestif moyen. Notre revue fournit une synthèse des régulateurs peptidiques connus pour contrôler l'alimentation et la digestion chez les insectes. Nous décrivons la découverte et le rôle fonctionnel de ces processus dans le cas des peptides allatorégulateurs, des hormones diurétiques, des peptides apparentés aux amides FMRF, du neuropeptide F (court), de la proctoline, des peptides stimulateurs de la production de salive, des kinines et des tachykinines des insectes. Ces peptides contrôlent la myoactivité du tube digestif, l'ingestion de nourriture et(ou) la libération des enzymes digestives. Certains peptides agissent à de multiples niveaux, possédant une fonction biologique qui dépend de leur site d'action. Plusieurs peptides régulateurs ont été extraits physiquement de différentes espèces d'insectes. Cependant, plusieurs projets de peptidomique, de protéomique, de transcriptomique et de génomique ont mené à de nombreuses découvertes supplémentaires et des prédict...

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Section: Neuropeptide F and Short Neuropeptide Fmentioning

confidence: 75%

Section: Fmrfamide-like Peptidesmentioning

confidence: 99%

Section: Fmrfamide-like Peptidesmentioning

confidence: 99%

Section: Proctolinmentioning

confidence: 99%

Section: Tachykinin-related Peptidesmentioning

confidence: 99%

See 3 more Smart Citations

Peptidergic control of food intake and digestion in insects¹This review is part of a virtual symposium on recent advances in understanding a variety of complex regulatory processes in insect physiology and endocrinology, including development, metabolism, cold hardiness, food intake and digestion, and diuresis, through the use of omics technologies in the postgenomic era.

et al. 2012

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The roles of enteroendocrine cell distribution and gustatory receptor expression in regulating peptide hormone secretion in the midgut of Bombyx mori larvae

Toyam,

Yamagishi,

Sato

2023

Arch Insect Biochem Physiol

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To regulate physiological homeostasis and behavior in Bombyx mori, more than 20 peptide hormones in the midgut of larvae are secreted upon detection of food substances at the lumen. Although it is logical to assume that the timings of peptide hormone secretions are regulated, little is known about the mechanisms. In this study, the distributions of enteroendocrine cells (EECs) producing five peptide hormones and EECs expressing gustatory receptors (Grs), as candidate receptors for luminal food substances and nutrients, were examined via immunostaining in B. mori larvae. Three patterns of peptide hormone distribution were observed. Tachykinin (Tk)‐ and K5‐producing EECs were located throughout the midgut; myosuppressin‐producing EECs were located in the middle‐to‐posterior midgut; and allatostatin C‐ and CCHamide‐2‐producing EECs were located in the anterior‐to‐middle midgut. BmGr4 was expressed in some Tk‐producing EECs in the anterior midgut, where food and its digestive products arrived 5 min after feeding began. Enzyme‐linked immunosorbent assay (ELISA) revealed secretion of Tk starting approximately 5 min after feeding began, suggesting that food sensing by BmGr4 may regulate Tk secretion. BmGr6 was expressed in a few Tk‐producing EECs in the middle‐to‐posterior midgut, although its significance was unclear. BmGr6 was also expressed in many myosuppressin‐producing EECs in the middle midgut, where food and its digestive products arrived 60 min after feeding began. ELISA revealed secretion of myosuppressin starting approximately 60 min after feeding began, suggesting that food sensing by BmGr6 may regulate myosuppressin secretion. Finally, BmGr9 was expressed in many BmK5‐producing EECs throughout the midgut, suggesting that BmGr9 may function as a sensor for the secretion of BmK5.

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Endocrine Control of Lipid Metabolism

Krishnan

2024

Advances in Experimental Medicine and Biology

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Effects of neuropeptides on feeding initiation in larvae of the silkworm, Bombyx mori

Cited by 45 publications

References 32 publications

The roles of enteroendocrine cell distribution and gustatory receptor expression in regulating peptide hormone secretion in the midgut of Bombyx mori larvae

Endocrine Control of Lipid Metabolism

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