Effects of neurotensin gene knockout in mice on the behavioral effects of cocaine

Hall, F. Scott; Centeno, Marjorie; Perona, Maria T. G.; Adair, Jordan E.; Dobner, Paul R.; Uhl, George R.

doi:10.1007/s00213-011-2370-9

Cited by 11 publications

(11 citation statements)

References 59 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Cocaine-conditioned place preference was assessed as described (21,22). Briefly, preferences for one side of the apparatus were assessed, four 20 min conditioning trials conducted (two cocaine, two saline) and preferences were assessed again 24 h after the last conditioning session.…”

Section: Cadherin 13: Human Cis-regulation and Selectively Altered Admentioning

confidence: 99%

Cadherin 13: Human cis-Regulation and Selectively Altered Addiction Phenotypes and Cerebral Cortical Dopamine in Knockout Mice

Drgonová

Walther

Hartstein

et al. 2016

Mol Med

Self Cite

View full text Add to dashboard Cite

The cadherin 13 (CDH13) gene encodes a cell adhesion molecule likely to influence development and connections of brain circuits that modulate addiction, locomotion and cognition, including those that involve midbrain dopamine neurons. Human CDH13 mRNA expression differs by more than 80% in postmortem cerebral cortical samples from individuals with different CDH13 genotypes, supporting examination of mice with altered CDH13 expression as models for common human variation at this locus. Constitutive CDH13 knockout mice display evidence for changed cocaine reward: shifted dose response relationship in tests of cocaine-conditioned place preference using doses that do not alter cocaine-conditioned taste aversion. Reduced adult CDH13 expression in conditional knockouts also alters cocaine reward in ways that correlate with individual differences in cortical CDH13 mRNA levels. In control and comparison behavioral assessments, knockout mice display modestly quicker acquisition of rotarod and water maze tasks, with a trend toward faster acquisition of 5-choice serial reaction time tasks that otherwise displayed no genotype-related differences. They display significant differences in locomotion in some settings, with larger effects in males. In assessments of brain changes that might contribute to these behavioral differences, there are selective alterations of dopamine levels, dopamine/metabolite ratios, dopaminergic fiber densities and mRNA encoding the activity dependent transcription factor npas4 in cerebral cortex of knockout mice. These novel data and previously reported human associations of CDH13 variants with addiction, individual differences in responses to stimulant administration and attention deficit hyperactivity disorder (ADHD) phenotypes suggest that levels of CDH13 expression, through mechanisms likely to include effects on mesocortical dopamine, influence stimulant reward and may contribute modestly to cognitive and locomotor phenotypes relevant to ADHD.

show abstract

Section: Cadherin 13: Human Cis-regulation and Selectively Altered Admentioning

confidence: 99%

Cadherin 13: Human cis-Regulation and Selectively Altered Addiction Phenotypes and Cerebral Cortical Dopamine in Knockout Mice

Drgonová

Walther

Hartstein

et al. 2016

Mol Med

Self Cite

View full text Add to dashboard Cite

show abstract

“…Reward and CPP were assessed (26,27). Briefly, side preferences were assessed, four 20-min conditioning trials were conducted (two cocaine, two saline) and preferences were assessed again 24 h after the last conditioning session.…”

Section: Mouse Behavioral Studies: Motor and Cocaine Effects And Learmentioning

confidence: 99%

“…Locomotion was recorded (a) during the 20-min pretest (in both halves of the 20 × 40-cm conditioning apparatus), conditioning (20 × 20-cm half of the apparatus) and test (20 × 40 cm) sessions and (b) in 42 × 42-cm sound-attenuated boxes to which the mice had not been previously exposed, for 120-min trials. Total distance traveled by mice that were untreated, saline treated and sampled before treatment, after one treatment and after the second treatment with cocaine was calculated from infrared beam breaks by an Optovarimax ATS System (27).…”

Section: Mouse Behavioral Studies: Motor and Cocaine Effects And Learmentioning

confidence: 99%

Mouse Model for Protein Tyrosine Phosphatase D (PTPRD) Associations with Restless Leg Syndrome or Willis-Ekbom Disease and Addiction: Reduced Expression Alters Locomotion, Sleep Behaviors and Cocaine-Conditioned Place Preference

Drgonová

Walther

Wang

et al. 2015

Mol Med

Self Cite

View full text Add to dashboard Cite

“…However, NT knockout (KO) mice did not differ from wild type (WT) or heterozygous mice in most measures of locomotor activity and conditioned place preference paradigms [182], suggesting a limited role for NT in cocaine addiction. In contrast, NT mediates the dopamine D1 receptor potentiation at GABA A synapses in the oval bed nucleus of the stria terminalis.…”

Section: Neurotensin and Substance Abusementioning

confidence: 99%

Elucidating the Role of Neurotensin in the Pathophysiology and Management of Major Mental Disorders

Boules

Fredrickson

Muehlmann

et al. 2014

Behavioral Sciences

View full text Add to dashboard Cite

Neurotensin (NT) is a neuropeptide that is closely associated with, and is thought to modulate, dopaminergic and other neurotransmitter systems involved in the pathophysiology of various mental disorders. This review outlines data implicating NT in the pathophysiology and management of major mental disorders such as schizophrenia, drug addiction, and autism. The data suggest that NT receptor analogs have the potential to be used as novel therapeutic agents acting through modulation of neurotransmitter systems dys-regulated in these disorders.

show abstract

Effects of neurotensin gene knockout in mice on the behavioral effects of cocaine

Abstract: These results suggest that endogenous NT is not involved in cocaine-mediated behaviors in most circumstances, but under some conditions, a slight prolongation of the effects of cocaine was observed in the absence of endogenous NT.

Cited by 11 publications

References 59 publications

Cadherin 13: Human cis-Regulation and Selectively Altered Addiction Phenotypes and Cerebral Cortical Dopamine in Knockout Mice

Cadherin 13: Human cis-Regulation and Selectively Altered Addiction Phenotypes and Cerebral Cortical Dopamine in Knockout Mice

Mouse Model for Protein Tyrosine Phosphatase D (PTPRD) Associations with Restless Leg Syndrome or Willis-Ekbom Disease and Addiction: Reduced Expression Alters Locomotion, Sleep Behaviors and Cocaine-Conditioned Place Preference

Elucidating the Role of Neurotensin in the Pathophysiology and Management of Major Mental Disorders

Contact Info

Product

Resources

About