Effects of Ni - substitution on structural, magnetic hyperthermia, photocatalytic and cytotoxicity study of MgFe2O4 nanoparticles

Manohar, Ala; Vijayakanth, V.; Pallavolu, Mohan Reddy; Kim, Ki Hyeon

doi:10.1016/j.jallcom.2021.160515

Cited by 60 publications

(19 citation statements)

References 79 publications

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“…The data show that the lattice parameter marginally increased with the Ca 2+ concentration of the substituent. This may be due to the replacement of higher ionic radii of Ca 2+ (>1.0 Å) 21 with smaller ionic radii of Mg 2+ (0.72 Å) 19 in octahedral (O B ) and tetrahedral (T A ) ligand voids in the spinel lattice. This enhanced the unit cell parameter and octahedral and tetrahedral volume modulation, modifying the magnetic exchange interaction strength and coupling constant among magnetic cations in the spinel structure.…”

Section: Resultsmentioning

confidence: 99%

“…Subsequently, the reaction mixture was cooled to room temperature. Precipitated nanoparticles were separated by centrifugation . The synthesis process is schematically shown in Figure .…”

Section: Methodsmentioning

confidence: 99%

“…Precipitated nanoparticles were separated by centrifugation. 19 The synthesis process is schematically shown in Figure 1. As-synthesized nanocrystals were dispersed and preserved in n-hexane (nonpolar solvent), called the stock solution, for further use.…”

Section: Introductionmentioning

confidence: 99%

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Ca-Doped MgFe₂O₄ Nanoparticles for Magnetic Hyperthermia and Their Cytotoxicity in Normal and Cancer Cell Lines

Manohar

Vijayakanth

Vattikuti

et al. 2022

ACS Appl. Nano Mater.

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Localized magnetic hyperthermia (LMHT) cancer therapy is a much-anticipated technique along with immunotherapy. LMHT can be used as an independent or adjunct therapy to increase the efficacy of radiation and chemotherapy. The superparamagnetic nanoparticles (SPNPs) create LMHT by the electron magnetic spin relaxation (EMR) mechanism in nanocolloids. Magnetic nanoparticles of MgFe2O4 doped with different concentrations of Ca2+ ions were designed to find specific heating efficiency in magnetic hyperthermia (MHT) for applications in cancer therapy. Ca2+-substituted MgFe2O4 (Ca x Mg1–x Fe2O4, x = 0.1, 0.3, and 0.5) nanoparticles with cubic spinel shapes and significant sizes were synthesized using high boiling point organic solvents. The heating efficiency or specific loss power (SLP) was determined using a calorimetric method under various amplitudes of the magnetic field. The best shape with a particular size range for nanoparticles dispersed in deionized (DI) water carriers producing the optimum heating efficiency was specified. The Ca x Mg1–x Fe2O4 (x = 0.1, 0.3, and 0.5) nanoparticles were investigated for in vitrocytotoxicity in normal cells (the mouse muscle fibroblast cell line BLO-11 and the mouse embryonic fibroblast cell line NIH 3T3) and human cancer cells (breast cancer cell line MDA-MB-23 and prostate cancer cell line PC-3) in terms of cell viability. The excellent heating efficiency and biocompatibility along with the lack of cell cytotoxicity of Ca2+-substituted MgFe2O4 nanoparticles were observed. These outcomes propose that MgFe2O4 nanoparticles doped with Ca2+ ions are appropriate for biomedical applications, especially for MHT cancer therapy.

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Section: Resultsmentioning

confidence: 99%

“…Subsequently, the reaction mixture was cooled to room temperature. Precipitated nanoparticles were separated by centrifugation . The synthesis process is schematically shown in Figure .…”

Section: Methodsmentioning

confidence: 99%

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Ca-Doped MgFe₂O₄ Nanoparticles for Magnetic Hyperthermia and Their Cytotoxicity in Normal and Cancer Cell Lines

Manohar

Vijayakanth

Vattikuti

et al. 2022

ACS Appl. Nano Mater.

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“…The cytotoxicity analysis of the functionalized-NPs was done on MCF-7 and MDA-MB-231 (breast cancer cells) and keratinocytes (normal cells). The functionalized-NPs were found to be biocompatible with the normal cells but were able to reduce cancer cell viability to 23-60% at concentrations of 25-1000 μg mL -1 via ROS generation and ferroptosis (Manohar, Vijayakanth, et al, 2021). Ni doped Zn ferrites are exploited as self-controlled heaters because of their moderate M s and low coercivity.…”

Section: Iron-oxide Based Nanomaterials Used For Magnetic Hyperthermiamentioning

confidence: 99%

Surface modified iron-oxide based engineered nanomaterials for hyperthermia therapy of cancer cells

Dhiman¹

2022

Preprint

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Magnetic hyperthermia is emerging as a promising alternative to the currently available cancer treatment modalities. Superparamagnetic iron-oxide nanoparticles (SPIONs) are extensively studied functional nanomaterials for biomedical applications, owing to their tunable physio-chemical properties and magnetic properties. Out of various ferrite classes, spinel and inverse-spinel ferrites are widely used but are affected by particle size distribution, particle shape, particle-particle interaction, geometry and crystallinity. Notably, their heating ability makes them suitable candidates for heat-mediated cancer cell ablation or hyperthermia therapy. Exposing SPIONs to an externally applied magnetic field of appropriate frequency and intensity cause them to release heat to ablate cancer cells. Majorly, three heating mechanisms are exhibited by magnetic nanomaterials: Nèel relaxation, Brownian relaxation and hysteresis losses. In SPIONs, Nèel and Brownian relaxations dominate whereas hysteric losses are negligible. These nanomaterials possess high magnetization values capable of generating heat to ablate cancer cells. Furthermore, surface functionalization of these materials imparts the ability to selectively target cancer cells and deliver cargo to the affected area sparing the normal body cells. The surface of nanoparticles can be functionalized with various physical, chemical and biological coatings. Moreover, hyperthermia can be applied in combination with other cancer treatment modalities in order to enhance the efficiency of treatment.

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“…Magnetic properties and morphology of metallic (Fe, Co) and metallic oxides (Fe 3 O 4 , CoFe 2 O 4 , Zn-Ni ferrites) single-domain nanoparticles (NPs) attract a lot of attention in the scientific community because of their significant potential in biomedical applications such as hyperthermia, targeted drug delivery, and magnetic resonance imaging. [1][2][3][4][5] Despite experimentally proved practical significance of iron oxide NPs in hyperthermia, the search for better combination of functional properties (high magnetic moment, high drug-loading capacity, high specific absorption rate [SAR], biocompatibility) is recently initiated in order to design NP-based nanodevices for theranostics that combine both diagnostic process and therapy. For this particular application, FeCo-based NPs seem to be the best choice as they demonstrate the highest value of saturation magnetization M S , [1] which is the critical parameter for high SAR value as well as for high sensitivity of smart drug delivery nanodevices to external magnetic field.…”

Section: Introductionmentioning

confidence: 99%

Local Atomic Order, Morphology, and Magnetic Properties in Silica‐Coated FeCo Nanoparticles Synthesized by Coprecipitation Technique

Fedotova

2022

Physica Status Solidi (b)

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Nanoparticles (NPs) of pure Fe25Co75 are sintered by Fe and Co coprecipitation followed by SiO2 deposition by tetraethoxysilane hydrolysis to form silica‐coated Fe25Co75 NPs ((Fe25Co75)x(SiO2)100–x (90 ≤ x ≤ 10, wt%)). Study of the morphology and phase composition of (Fe25Co75)x(SiO2)100–x nanopowders evidences the formation of agglomerations of NPs with individual medium diameter ≈20–50 nm containing partially oxidized cores of α‐FeCo bcc alloy covered with amorphous SiO2. Mössbauer spectroscopy clearly reveals that coverage with SiO2 shells promotes up to four‐time enhancement of resistance of FeCo cores to undesirable formation of surface Fe(Co) hydroxides. Temperature dependencies of magnetization recorded under field‐cooled (FC) and zero‐field‐cooled (ZFC) protocols for uncoated Fe25Co75 and (Fe25Co75)70(SiO2)30 nanopowders reveal that some part of NPs being in single‐domain state form superferromagnetic long‐range ordering.

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Effects of Ni - substitution on structural, magnetic hyperthermia, photocatalytic and cytotoxicity study of MgFe2O4 nanoparticles

Cited by 60 publications

References 79 publications

Ca-Doped MgFe₂O₄ Nanoparticles for Magnetic Hyperthermia and Their Cytotoxicity in Normal and Cancer Cell Lines

Ca-Doped MgFe₂O₄ Nanoparticles for Magnetic Hyperthermia and Their Cytotoxicity in Normal and Cancer Cell Lines

Surface modified iron-oxide based engineered nanomaterials for hyperthermia therapy of cancer cells

Local Atomic Order, Morphology, and Magnetic Properties in Silica‐Coated FeCo Nanoparticles Synthesized by Coprecipitation Technique

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Effects of Ni - substitution on structural, magnetic hyperthermia, photocatalytic and cytotoxicity study of MgFe2O4 nanoparticles

Cited by 60 publications

References 79 publications

Ca-Doped MgFe2O4 Nanoparticles for Magnetic Hyperthermia and Their Cytotoxicity in Normal and Cancer Cell Lines

Ca-Doped MgFe2O4 Nanoparticles for Magnetic Hyperthermia and Their Cytotoxicity in Normal and Cancer Cell Lines

Surface modified iron-oxide based engineered nanomaterials for hyperthermia therapy of cancer cells

Local Atomic Order, Morphology, and Magnetic Properties in Silica‐Coated FeCo Nanoparticles Synthesized by Coprecipitation Technique

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Product

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About

Ca-Doped MgFe₂O₄ Nanoparticles for Magnetic Hyperthermia and Their Cytotoxicity in Normal and Cancer Cell Lines

Ca-Doped MgFe₂O₄ Nanoparticles for Magnetic Hyperthermia and Their Cytotoxicity in Normal and Cancer Cell Lines