Effects of niacin on intestinal epithelial Barrier, intestinal Immunity, and microbial community in weaned piglets challenged by PDCoV

Chen, Yibo; Li, Ping; Zhen, Rui; Wang, Li; Feng, Junwei; Xie, Yongsheng; Yang, Bijing; Xiong, Ye; Niu, Jiawei; Wu, Qiwen; Jiang, Zongyong; He, Dongsheng; Yi, Hongbo

doi:10.1016/j.intimp.2022.109054

Cited by 11 publications

(3 citation statements)

References 71 publications

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“…Consistent with this result, our study found that 1000 mg/kg FD decreased the serum IFN-γ, TNF-α and IL-8 contents of broilers. The IFN-γ, TNF-α and IL-8 are important mediators of the inflammatory response, which play key roles when inflammation occurs [ 39 , 40 ]. These results imply that dietary supplementation with 1000 mg/kg FD could reduce the likelihood of inflammation in broilers.…”

Section: Discussionmentioning

confidence: 99%

Effect of fermented dandelion on productive performance, meat quality, immune function, and intestinal microbiota of broiler chickens

Mao,

Wang,

Duan

et al. 2023

BMC Vet Res

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Background Dandelion has a great potential to be used as feed additive. Using microbial fermentation technology to degrade cell walls is conducive to enable better release of bioactive compounds of dandelion. This study intended to explore the effect of fermented dandelion (FD) on production performance, meat quality, immune function, and intestinal microbiota of broiler chickens. One-hundred and twenty 1-day-old male Arbor Acres broiler chickens were randomly allotted into three treatments: CON (basal diet, control), LFD and HFD (basal diet with 500 and 1000 mg/kg FD, respectively), with five replicates of eight birds each. The experiment lasted for 42 days. Results The results showed that birds in HFD group had increased ADG during 1–21 days (P < 0.05). On day 21, the bursa of Fabricius index of birds in LFD group was higher (P < 0.05), while the serum contents of IFN-γ and TNF-ɑ were lower in HFD group (P < 0.05). FD supplementation decreased the observed_species, shannon, chao1 and ace indexes (P < 0.05) as well as the abundance of Bacteroidota, Bacteroides, and Alistipes (P < 0.05). Birds in HFD group had higher abundance of Firmicutes and lower abundance of Verrucomicrobiota (P < 0.05). LFD group had lower abundance of unidentified_bacteria (P < 0.05). On day 42, the abdominal fat yield of HFD group was decreased (P < 0.05). Birds in LFD group had lower L* and b* values of breast muscle (P < 0.05), while higher spleen index. The CAT activities of breast muscle of FD groups were higher (P < 0.05). Conclusion In summary, dietary FD supplementation at 1000 mg/kg improved production performance and immune function and modulated microbiota composition in ileum of broiler chickens. FD can be supplemented in the diet to enhance performance and health of broiler chickens, of which 1000 mg/kg FD is more effective.

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Section: Discussionmentioning

confidence: 99%

Effect of fermented dandelion on productive performance, meat quality, immune function, and intestinal microbiota of broiler chickens

Mao,

Wang,

Duan

et al. 2023

BMC Vet Res

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“…Adding 40 mg of niacin has been shown to alleviate the symptoms of PDCoV infection, namely diarrhoea, intestinal barrier damage, intestinal immune response, and microflora dysfunction. Niacin can potentially mitigate the inflammatory response by suppressing the activation of the TLR2/TLR4-NF-κB signalling pathway and modulating histone acetylation via GPR109A in the intestinal tract [94].…”

Section: Vitamin Bmentioning

confidence: 99%

“…The following supporting information can be downloaded at: https: //www.mdpi.com/article/10.3390/ani14081218/s1, Table S1: Graphical abstract of stress sources, biomarkers, signalling pathways and stress effect in swine; Table S2: Summary of the most important studies about the additional supplementation of vitamins in swine. References [71][72][73][74]76,[87][88][89][90]92,94,97,111,121,138,139,[141][142][143][144][145][146][149][150][151][152][153]161,163,165] are cited in the supplementary materials.…”

Section: Supplementary Materialsmentioning

confidence: 99%

The Role of Vitamins in Mitigating the Effects of Various Stress Factors in Pigs Breeding

Smołucha,

Steg,

Oczkowicz

2024

Animals

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Good practices in farm animal care are crucial for upholding animal well-being, efficiency, and health. Pigs, like other farm animals, are exposed to various stressors, including environmental, nutritional, chemical, psychological, physiological, and metabolic stressors, which can disrupt their internal balance and compromise their well-being. Oxidative stress can adversely affect animal performance, fertility, and immunity, leading to economic losses for farmers. Dietary considerations are hugely important in attaining these objectives. This paper reviews studies investigating the impact of additional vitamin supplementation on stress reduction in pigs. Vitamin A can be beneficial in counteracting viral and parasitic threats. Vitamin B can be a potential solution for reproductive issues, but it might also be beneficial in reducing the effects of inappropriate nutrition. Vitamin C plays a vital role in reducing the effects of heat stress or exposure to toxins in pigs. Vitamin D proves to be beneficial in addressing stress induced mostly by infections and weaning, while vitamin E has been shown to mitigate the effects of toxins, heat stress, or transport stress. This review highlights the potential benefits of these dietary antioxidants in maintaining pig health, enhancing productivity, and counteracting the adverse effects of various stressors. Understanding the role of vitamins in pig nutrition and stress management is vital for optimising farm animal welfare and production efficiency.

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Ferulic acid ameliorates ulcerative colitis in a rat model via the inhibition of two LPS-TLR4-NF-κB and NF-κB-INOS-NO signaling pathways and thus alleviating the inflammatory, oxidative and apoptotic conditions in the colon tissue

et al. 2023

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Effects of niacin on intestinal epithelial Barrier, intestinal Immunity, and microbial community in weaned piglets challenged by PDCoV

Cited by 11 publications

References 71 publications

Effect of fermented dandelion on productive performance, meat quality, immune function, and intestinal microbiota of broiler chickens

Effect of fermented dandelion on productive performance, meat quality, immune function, and intestinal microbiota of broiler chickens

The Role of Vitamins in Mitigating the Effects of Various Stress Factors in Pigs Breeding

Ferulic acid ameliorates ulcerative colitis in a rat model via the inhibition of two LPS-TLR4-NF-κB and NF-κB-INOS-NO signaling pathways and thus alleviating the inflammatory, oxidative and apoptotic conditions in the colon tissue

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