Effects of nicotinic acid upon post-burn oedema: a preliminary report of clinical trials

Wells, Charles H.; Hilton, James G.; Larson, Duane L.; Sloan, David F.

doi:10.1016/s0305-4179(76)80017-4

Cited by 6 publications

(1 citation statement)

References 22 publications

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“…The use of pharmacologic agents to reduce postbum vascular permeability and decrease fluid needs has been advocated on the basis of laboratory studies. However, clinical evaluations of two agents, heparin and nicotinic acid, have been largely anecdotal or the results have been at variance with laboratory studies [32,33]. Nicotinic acid has recently been repudiated because of hepatic necrosis occurring in some patients receiving the drug [34].…”

Section: Harkin's-nrc Formulamentioning

confidence: 99%

Advances in fluid therapy and the early care of the burn patient

Pruitt

1978

World j. surg.

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The resuscitation and early care of the burn patient has been placed on a more sound physiologic basis as a result of recent studies of the pathologic effects of thermal injury and the clinical application of technological advances. Whichever resuscitation formula is employed, its application should be guided by the patient's response to treatment. The surgeon must preserve vital organ function while taking advantage of compensatory mechanisms to minimize the deleterious effects of both the injury and the therapy. Resuscitation using only balanced salt solution in the first 24 hours, and reserving colloid-containing fluids for the second 24 hours, is clinically effective in the vast majority of burn patients, but should be altered in terms of volume and composition to meet the particular needs of any given burn patient. Repeated planned monitoring of cardiopulmonary function and of the peripheral circulation is mandatory to achieve maximum survival of unburned tissue and to reduce mortality. Careful fluid management, including daily assessment of fluid balance, is required from the time of admission until the burn wound has healed or been grafted.Methods of resuscitation of the extensively burned patient have changed strikingly during the past half century with a resultant marked reduction of morbidity and mortality due to burn shock, hypovolemia, and acute renal failure. The importance of salt-containing fluids in restoring blood volume deficits in the early postburn period was first recognized by Parascondolo

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Section: Harkin's-nrc Formulamentioning

confidence: 99%