Effects of Nifedipine during Low, Normal and High Intakes of Sodium in Patients with Essential Hypertension

Valdés, Gloría; Soto, M. E.; Croxatto, H.; Bellolio, T; Corbalán, Ramón; Casanegra, P

doi:10.1042/cs063447s

Cited by 14 publications

(4 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These data are in accordance with previous results for nifedipine. An increase in PRA has been reported in some studies (Aoki etal., 1979;Olivari et al, 1979;Valdes et al, 1982), while others have found no significant changes (Thibonnier et al, 1980;Soto et.al., 1981 Figure 2 Proximal reabsorption of sodium. NT normotensive; HThypertensive; *P <0.05, **P <0.01.…”

Section: Hmentioning

confidence: 90%

Antihypertensive and renal effects of nicardipine.

Schaik¹,

Nistelrooy²,

Geyskes³

1984

Brit J Clinical Pharma

View full text Add to dashboard Cite

Both the acute blood pressure lowering and renal effects of the calcium antagonist nicardipine and those after 1 week's treatment were investigated in 10 normotensive volunteers and in 10 patients with mild to moderate essential hypertension. 2 After 1 week of placebo, nicardipine was administered orally for 1 week (20 mg three times daily), Investigations, done on the first and last day of nicardipine treatment were compared with those on the last day of placebo. 3 During water loading, nicardipine increased urinary volume and urinary excretion of sodium significantly after 1 week nicardipine treatment. 4 In the normotensive group the natriuretic effect was caused by a decrease of fractional proximal and distal reabsorption of sodium. In the hypertensive group the natriuresis was achieved mainly by an increase of the rate of glomerular filtration (GFR) and also by a slight distal effect. 5 Our results show that nicardipine had natriuretic effects. There were trends suggesting that the renal effects may differ between patients with essential hypertension and normotensive volunteers, but the findings might also be related to differences in age between the groups.

show abstract

Section: Hmentioning

confidence: 90%

Antihypertensive and renal effects of nicardipine.

Schaik¹,

Nistelrooy²,

Geyskes³

1984

Brit J Clinical Pharma

View full text Add to dashboard Cite

show abstract

“…Yokoyama & Kaburagi (1983) reported a diuresis in both normotensive and hypertensive subjects with and without chronic glomerulonephritis during an intravenous infusion of nifedipine. However Soto et al (1981) were unable to detect a natriuresis after oral administration of 20 mg nifedipine and Valdes et al (1982) found that urine volume increased following this dose only when the hypertensives were taking a high sodium diet.…”

Section: Introductionmentioning

confidence: 99%

The natriuresis following oral administration of the calcium antagonists‐nifedipine and nitrendipine.

Ene¹,

Williamson²,

Roberts³

et al. 1985

Brit J Clinical Pharma

View full text Add to dashboard Cite

1Ten healthy individuals received in random order placebo, nifedipine 10 mg, nifedipine 20 mg, nitrendipine 10 mg and nitrendipine 20 mg as single oral administrations at weekly intervals. On the day before each treatment placebo was administered. Urine was collected for 6 h and then for 18 h after each administration. 2 There was a significant increase in urine volume and sodium excretion after the drugs, but no change in potassium excretion. The effect was most evident in the 6 h after drug administration. The effect was no greater at the higher doses of either drug. 3 A natriuretic-diuretic action of nifedipine and nitrendipine has been confirmed in man. The mechanism of the effect remains unclear.

show abstract

“…Therefore, renal hemodynamics is not modified by nitrendipine even if the drug is effective in decreasing BP [1], A natriuretic effect, shown for nifedipine in humans [2,3] and for nitrendipine in animals [4] is not evident in our study; both urinary sodium excretion and body weight were unmodified after nitrendipine treatment. Similarly, no uricosuric effect has been detected in our patients, whereas increased uric acid excretion has been reported by others during treatment with nifedipine [5], Our study shows that nitrendipine is effective in de creasing BP, but only a few hours after its administration.…”

Section: Discussionmentioning

confidence: 68%