Effects of nitric oxide on matrix metalloproteinase-2 production by rheumatoid synovial cells

Hirai, Yasuko; Migita, Kiyoshi; Honda, Seiyo; Ueki, Yukitaka; Yamasaki, Satoshi; Urayama, Satoshi; Kamachi, Makoto; Kawakami, Atsushi; Ida, Hiroaki; Kita, Masako; Fukuda, Takaaki; Shibatomi, Kazutaka; Kawabe, Yojiro; Aoyagi, Takahiko; Eguchi, Katsumi

doi:10.1016/s0024-3205(00)00998-x

Cited by 44 publications

(24 citation statements)

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“…The currently reported increase in various salivary antioxidant parameters is of no surprise; in recent years, oxidative stress has become increasingly recognized as one of the major factors contributing to the chronic inflammatory process both in RA and in JIA patients (9,11,(29)(30)(31)(32)(33). Furthermore, increased MMP expression and activity was reportedly induced by the greater oxidative stress in general and also in rheumatoid synovial cells, as was shown in numerous studies; and vice versa, MMP expression and activity was decreased by antioxidants such as vitamin E or SOD (18,(34)(35)(36)(37)(38)(39)(40). It is also worth noting recent reports demonstrating that the bioflavonoid Hesperidin protects against the effects of nicotine by reversing the nicotine-induced parallel increase of both oxidative stress and enhanced MMP expression (19,41,42).…”

Section: Discussionmentioning

confidence: 74%

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Salivary Antioxidants and Metalloproteinases in Juvenile Idiopathic Arthritis

Brik

Rosen

Savulescu

et al. 2009

Mol Med

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Juvenile idiopathic arthritis (JIA) is the most common autoimmune inflammatory disease in children; joint inflammation is the hallmark of the disease. Thirty-five children with JIA were studied, of whom 26 had active disease and 14 were receiving anti-TNF therapy (5 with Infliximab, 9 with Etanercept). Sixteen healthy controls also were studied. Saliva samples were obtained for analysis of anti-oxidant status, metalloproteinases (MMPs) and sialochemistry. The total antioxidant status was significantly higher in the saliva of all JIA patients, whether treated (P = 0.014) or not treated (P = 0.038) with anti-TNF agents. The increase in antioxidant status (TAS) in the saliva of the active patients was nearly two times higher than that of non-active patients (P = 0.01). MMP levels were significantly lower in JIA patients than in controls. MMP-9, MMP-3 and MMP-2 were lower in JIA patients without anti-TNF treatment by 36.7% (P = 0.01), 30.0% (P = 0.0001) and 10.7% (P = 0.0001), respectively. A greater reduction in MMP levels was observed in the group of patients treated with anti-TNF drugs: MMP-9, MMP-3 and MMP-2 were lower than in controls by 51.1% (P = 0.0001), 61.5% (P = 0.0001) and 55.4% (P = 0.0001), respectively. Children with JIA exhibited a significantly higher salivary antioxidant activity and significantly lower MMP levels. Anti-TNF treatment was associated with a further decrease in MMP levels in the saliva of JIA patients while an active state of JIA was associated with a further increase in the salivary antioxidant activity. Anti-TNF treatment may modulate the degradation process during the course of arthritis by inhibition of the activity of MMP .

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Section: Discussionmentioning

confidence: 74%

“…The MMPs are a family of zincdependent endopeptidases capable of degrading all components of the extracellular matrix, and MMPs contribute significantly to tissue destruction. The pathognomonic destruction of cartilage and bone in JIA is mediated largely by proteolytic enzymes, among which the MMPs play a critical role (15,18,19).…”

Section: Introductionmentioning

confidence: 99%

Salivary Antioxidants and Metalloproteinases in Juvenile Idiopathic Arthritis

Brik

Rosen

Savulescu

et al. 2009

Mol Med

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“…24 NO has been implicated in the development of both central 25 and peripheral pain. 26 27 It has been implicated as one of the important mediators of articular damage, in part through modulation of production of metalloproteinases by the rheumatoid cells 28 and apoptosis. 29 Several drugs, including non-steroidal anti-inflammatory drugs, 30 tetracyclines, 31 corticosteroids, 32 and immunosuppressive drugs such as cyclosporin A and mycophenolate mofetil, attenuate the activation of NO.…”

Section: Discussionmentioning

confidence: 99%

Active leflunomide metabolite inhibits interleukin 1β, tumour necrosis factor α, nitric oxide, and metalloproteinase-3 production in activated human synovial tissue cultures

Elkayam

Yaron²,

Shirazi³

et al. 2003

Annals of the Rheumatic Diseases

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“…Recent studies, however, suggest that MMPs may promote EMT by altering the E-cadherin/β-catenin pathway [14,23,42,43]. Specifically, the association between the cell-cell adhesion molecule, E-cadherin, and cytoskeletal protein, β-catenin has been shown to be vulnerable to enzymatic attack by multiple MMPs, including MMP-9 and MMP-2 [42,44,45]. Proteolytic cleavage of the N-terminal extracellular domain of E-cadherin by MMPs results in the shedding of E-cadherin and formation of extracellular domain fragments ranging in size from 50 to 85 kDa, that are often secreted into the conditioned media of cultured cells [46] and have been detected in vivo in urine, blister fluid of cutaneous diseases and the circulation of cancer patients [47][48][49].…”

Section: Mmp and Ascmentioning

confidence: 99%

Matrix metalloproteinases as mediators of primary and secondary cataracts

West‐Mays

Pino

2007

Expert Review of Ophthalmology

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The matrix metalloproteinases (MMPs) are a family of endopeptidases involved in numerous remodeling and fibrotic disorders. Although MMPs have been shown to play important roles in regenerative and disease processes in many parts of the eye, including the cornea, retina and trabecular meshwork, the role of MMPs in the normal and cataractous lens has only recently been studied. These investigations have shown that multiple MMPs are expressed in the lens and their expression is altered in a number of cataract phenotypes. However, anterior subcapsular cataract and posterior capsular opacification, cataracts of a fibrotic nature, show a particular involvement of MMPs. This review will highlight recent findings that suggest a causative role for MMPs in these fibrotic cataract phenotypes. Keywords cataract; EMT; fibrosis; lens; MMPIs; matrix metalloproteinase Cataract is the leading cause of blindness worldwide despite the availability of effective surgery in the developed countries [1,2]. The etiology of cataract is diverse (see Allen [3] for review) with the majority of cataracts related to aging. Extracapsular cataract extraction provides quick restoration of vision and is the most frequently performed surgical procedure in the developed world, costing over US$3.5 billion each year in the USA alone [4]. However, it is not without its problems and can lead to complications such as the development of secondary cataract (up to 40-50% incidence of patients), also known as posterior capsular opacification (PCO) [5,6]. PCO is a major medical problem with profound consequences to the patient's well-being and is a significant financial burden. PCO is considered a proliferative, fibrotic disorder that involves the aberrant deposition of matrix and wrinkling of the lens capsule [7]. Another cataract type, also of a fibrotic nature, is anterior subcapsular cataract (ASC) [6,8,9]. ASC, unlike PCO, is a primary cataract that occurs when lens epithelial cells (LECs), in situ, are stimulated to transition into myofibroblasts. These fibroblasts form subcapsular plaques directly beneath the lens capsule. Despite these differences, recent evidence has shown that in both cataract phenotypes the matrix metalloproteinases (MMPs), matrix-degrading enzymes, †Author

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Effects of nitric oxide on matrix metalloproteinase-2 production by rheumatoid synovial cells

Cited by 44 publications

References 0 publications

Salivary Antioxidants and Metalloproteinases in Juvenile Idiopathic Arthritis

Salivary Antioxidants and Metalloproteinases in Juvenile Idiopathic Arthritis

Active leflunomide metabolite inhibits interleukin 1β, tumour necrosis factor α, nitric oxide, and metalloproteinase-3 production in activated human synovial tissue cultures

Matrix metalloproteinases as mediators of primary and secondary cataracts

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