Effects of nitrofurazone on correction of abdominal wall defect treated with polypropylene mesh involved by fibrous tissue

Yasojima, Edson Yuzur; Júnior, Rubens Fernando Gonçalves Ribeiro; Pessoa, Thyago Cezar Prado; Cavalcante, Lainy Carollyne da Costa; Ramos, Suzana Rodrigues; Gouveia, Eduardo Henrique Herbster; Galvão, Lucas Nascimento; Serruya, Yuri Aarão Amaral; Moraes, Mateus Malta de

doi:10.1590/s0102-865020150100000006

Cited by 3 publications

(5 citation statements)

References 12 publications

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“…The studies used different test subjects: five used mice, 19-23 36 rats, 24-59 eight rabbits, 60-67 one dogs, 68 two pigs, 69,70 and six used humans. 10,12,71-74 The studies comprised a total of 408 humans and 2679 animals.…”

Section: Resultsmentioning

confidence: 99%

“…The types of hernias were mainly incisional, but two studies investigated inguinal hernias, 10,71 one hiatal hernias, 12 and one diaphragmatic hernias. 63 The anatomic placement of the mesh was not described in 14 studies, 20,23,28,33,39,45,47,55,62,65,66,71,73,74 29 were in an onlay position, 10,21,22,24,27,29–32,35,36-38,40-43,48,51,52,54,56,58-61,64,70,72, four inlay, 26,34,49,57 two sublay, 25,46 three underlay, 24,68,69 two preperitoneal, 19,44 two intraperitoneal, 50,67 and in two studies the meshes were placed on the diaphragm. 12,…”

Section: Resultsmentioning

confidence: 99%

“…The most used coatings were mesenchymal stem cells 19,20,24-27,69,72 and platelet-rich plasma. 10,12,60,61,68,71 Several other coatings were used such as different growth factors, 37,53,64 vitamin E, 66 collagen-derived products, 39-41,73 various polysaccharides, 39,43-46,62 silk proteins, 50,65 gentamycin, 21,22,54,55 doxycycline, 53 nitrofurantoin, 42 titanium, 59 diamond-like carbon, 57,74 copaiba oil, 52 etc. These coatings were divided into biological (animal/human-derived), synthetic resorbable materials, or other materials (Figure 2).…”

Section: Resultsmentioning

confidence: 99%

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Coatings for Permanent Meshes Used to Enhance Healing in Abdominal Hernia Repair: A Scoping Review

Baker,

Rosenberg

2024

Surg Innov

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Introduction Hernia meshes are used to reduce recurrence and pain rates, but the rates are still high. This could be improved with coatings of the mesh. This scoping review aimed to provide an overview of mesh coatings used to promote healing in abdominal hernia repair and to report beneficial and unbeneficial effects. Methods We included human and animal studies with abdominal hernias that were repaired with non-commercially coated meshes. We searched Pubmed, Embase, Cochrane Central, LILACS, and CNKI without language constraints. Results Of 2933 identified studies, 58 were included: six studies had a total of 408 humans and 52 studies had 2679 animals. The median follow-up was 12 months (range 1-156), and 95% of the hernias were incisional. There were 44 different coatings which included platelet-rich plasma, mesenchymal stem cells, growth factors, vitamin E, collagen-derived products, various polysaccharides, silk proteins, chitosan, gentamycin, doxycycline, nitrofurantoin, titanium, and diamond-like carbon. Mesenchymal stem cells and platelet-rich plasma were the most researched. Mesenchymal stem cells notably reduced inflammation and foreign body reactions but did not impact other healing metrics. In contrast, platelet-rich plasma positively influenced tissue ingrowth, collagen deposition, and neovascularization and had varying effects on inflammation and foreign body reactions. Conclusion We identified 44 different mesh coatings and they showed varying results. Mesenchymal stem cells and platelet-rich plasma were the most studied, with the latter showing considerable promise in improving biomechanical properties in hernia repair. Further investigations are needed to ascertain their definitive use in humans.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Coatings for Permanent Meshes Used to Enhance Healing in Abdominal Hernia Repair: A Scoping Review

Baker,

Rosenberg

2024

Surg Innov

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“…The rats were weighed and anesthetized using an intraperitoneal injection of ketamine hydrochloride 10% and xylazine hydrochloride 2% (70 mg/kg and 10 mg/kg, respectively). During the surgical procedures, additional doses were administered if necessary 13 .…”

Section: ■ Methodsmentioning

confidence: 99%

Remote ischemic conditioning protects against testicular ischemia∕reperfusion injury in rats

et al. 2020

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“…One of the routine treatments of superficial second-degree burns is daily washing and dressing with Nitrofurazone (2%) ointment (10). Nitrofurazone is a topical anti-infective agent which is effective against gram-negative and gram-positive bacteria (11). This ointment is widely used to treat various types of superficial wounds including burns.…”

Section: Introductionmentioning

confidence: 99%

Comparison of the effectiveness of Aloe Vera Gel with 2% Nitrofurazone ointment on the healing of superficial second-degree burns. Randomised clinical trial

Varaei

Ranjbar

Sabaghzadeh³

et al. 2020

Preprint

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Background Burn injuries are one of the most common sources of trauma globally that comprise a significant drain on long-term personal and healthcare cost Large surface area burn wounds are difficult to manage and may result in significant physiologic and psychological sequelae . The aim of this study was to compare the effectiveness of Aloe Vera gel with Nitrofurazone ointment in the healing of superficial second-degree burn wounds.Methods The present study was a split body controlled, randomized clinical trial. The sample was recruited from patients with superficial second-degree burn wound who were prescribed to treat with 2% Nitrofurazone ointment. Thirty patients with at least two burn, each burn on an alternate side of the body, entered the study — samples allocated to two groups which received Aloe Vera gel or 2% Nitrofurazone ointment on their burns. Bates-Jensen Wound assessment tool (BWAT) was used to evaluate the healing of burns. The burns were evaluated before, one, two and three weeks after the beginning of treatment.Results The mean ± SD of BWAT scores in Aloe Vera zones were 30.32 ± 3.28, 27.33 ± 3.38, 21.33 ± 3.13, 16.12 ± 2.16 respectively (F(2, 65.07) =440.00, p=0.001). The mean ± SD of BWAT scores in Nitrofurazone ointment zones were 30.51 ± 3.79, 28.45 ± 3.49, 23.36 ± 2.89, 19.23 ± 2.11 (F(1, 52.00) =228.00, p=0.001).Conclusions There is a significant difference in (BWAT) scores between intervention and control groups. Aloe Vera gel was as effective as Nitrofurazone ointment in the treatment of superficial second-degree burns.Trial registration IRCT2014113020151N1. Registered 14 December 2014, https://www.irct.ir/trial/17874

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Effects of nitrofurazone on correction of abdominal wall defect treated with polypropylene mesh involved by fibrous tissue

Cited by 3 publications

References 12 publications

Coatings for Permanent Meshes Used to Enhance Healing in Abdominal Hernia Repair: A Scoping Review

Coatings for Permanent Meshes Used to Enhance Healing in Abdominal Hernia Repair: A Scoping Review

Remote ischemic conditioning protects against testicular ischemia∕reperfusion injury in rats

Comparison of the effectiveness of Aloe Vera Gel with 2% Nitrofurazone ointment on the healing of superficial second-degree burns. Randomised clinical trial

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