An experiment was conducted at the farm of Afghanistan National Agricultural Science and Technology University (ANASTU), Kandahar Province, Afghanistan in cropping season of 2020 to investigate the Optimization of Crop Establishment methods and Phosphorus Fertilizer levels on Growth and Economic Efficiency of Groundnut under Semi-arid region of Afghanistan. The experimentation was conducted in split-plot design with 15 treatment combinations and replicated thrice. main-plot consisted of crop establishment methods, viz. ridge and furrow (RF), broad bed and furrow (BBF) and flatbed (FB), while the sub-plots comprised of phosphorus levels, viz. absolute control, 20, 40, 60 and 80 kg P2O5/ ha. The results of the investigation revealed that the growth parameters in terms of plant height in and leave area were highest in BBF, followed by FB and minimum was in RF. Adoption of BBF recorded significantly higher gross return (238928 AFN/ha), net return (202728 AFN/ha) and net benefit cost of ratio (5.2) were in Broad Bed and Furrow, followed in ridged and furrow and the minimum was in flat bed method. It can be concluded, cultivating of groundnut with Broad Bed and Furrow with application of 60 kg P2O5/ha was found beneficial for reaching higher productivity and profitability under semi-arid region of Afghanistan.