Effects Of NKH477 On Endothelin‐1‐Induced Renal Responses In Anaesthetized Dogs

Hara, Sunao; Tanahashi, Masayuki; Yoshida, Makoto; Suzuki-Kusaba, Mizue; Hisa, Hiroaki; Satoh, Susumu

doi:10.1046/j.1440-1681.2000.03282.x

Cited by 2 publications

(3 citation statements)

References 11 publications

(14 reference statements)

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“…CDH (0.25 µg/kg/min) increased the RBF significantly without reducing the BP, but higher doses of CDH had little effect on the RBF. Intrarenal arterial infusion of CDH (300 ng/kg/min) increased the RBF in anesthetized dogs [5, 6]. Although we administered CDH intravenously, our results are consistent with these findings.…”

Section: Discussionsupporting

confidence: 87%

“…It acts directly on adenylate cyclase to increase intracellular cyclic adenosine monophosphate (cAMP) levels [4], with positive inotropic effects and lowering of the blood pressure (BP) [1]. Several investigators have shown that intrarenal arterial infusion of CDH increases the renal blood flow (RBF) in anesthetized dogs [5, 6]. More recently, Ogata et al [7]reported that CDH is capable of maintaining the urine volume, suggesting that CDH improves BP and RBF by maintaining the RBF in patients with heart failure.…”

Section: Introductionmentioning

confidence: 99%

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A Forskolin Derivative, Colforsin Daropate Hydrochloride, Inhibits the Decrease in Cortical Renal Blood Flow Induced by Noradrenaline or Angiotensin II in Anesthetized Rats

Ogata

Minami

Segawa³

et al. 2004

Nephron Physiol

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A forskolin derivative, colforsin daropate hydrochloride (CDH), acts directly on adenylate cyclase to increase the intracellular cyclic adenosine monophosphate levels which produce a positive inotropic effect and a lower blood pressure. However, little is known about the effects of CDH on the renal function. We used laser Doppler flowmetry to measure the cortical renal blood flow (RBF) in male Wistar rats given a continuous intravenous infusion of CDH and evaluated the effects of CDH on the noradrenaline (NA) and angiotensin II (AngII) induced increases in blood pressure and reductions in RBF. Continuous intravenous administration of CDH at 0.25 µg/kg/min did not affect the mean arterial pressure (MAP), but increased heart rate and RBF. Continuous intravenous administration of CDH at high doses (0.5–0.75 µg/kg/min) decreased the MAP, with little effect on the RBF. The administration of exogenous NA (1.7 µg/kg) increased the MAP and decreased the RBF. However, a bolus injection of NA did not decrease the RBF during continuous intravenous administration of CDH, and CDH did not affect the NA-induced increase in MAP. The administration of exogenous AngII (100 ng/kg) increased MAP and decreased RBF and heart rate, but a bolus injection of AngII did not decrease RBF during continuous intravenous administration of CDH. These results suggest that CDH plays a protective role against the pressor effects and the decrease in RBF induced by NA or AngII.

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Section: Discussionsupporting

confidence: 87%

Section: Introductionmentioning

confidence: 99%

A Forskolin Derivative, Colforsin Daropate Hydrochloride, Inhibits the Decrease in Cortical Renal Blood Flow Induced by Noradrenaline or Angiotensin II in Anesthetized Rats

Ogata

Minami

Segawa³

et al. 2004

Nephron Physiol

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“…Recently, much attention has been paid to the effects of CDH on renal function, and several investigators have reported that CDH increases renal blood flow in anesthetized dogs [8][9][10]. Ogata et al [11] reported that CDH maintains urine volume, which suggests that CDH improves blood pressure and renal blood flow (RBF) in patients with heart failure, and that CDH could be used to maintain RBF clinically.…”

Section: Introductionmentioning

confidence: 99%

A Forskolin Derivative, Colforsin Daropate Hydrochloride, Inhibits Rat Mesangial Cell Mitogenesis via the Cyclic AMP Pathway

Ogata

Minami²,

Segawa³

et al. 2003

Pharmacology

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A forskolin derivative, colforsin daropate hydrochloride (CDH), has been introduced as an inotropic agent that acts directly on adenylate cyclase to increase intracellular cyclic AMP (cAMP) levels and ventricular contractility, resulting in positive inotropic activity. We investigated the effects of CDH on rat mesangial cell (MC) proliferation. CDH (10^–7–10^–5 mol/l) inhibited [³H]thymidine incorporation into cultured rat MCs in a concentration-dependent manner. CDH (10^–7–10^–5 mol/l) also decreased cell numbers in a similar manner, and stimulated cAMP accumulation in MCs in a concentration-dependent manner. A protein kinase A inhibitor, H-89, abolished the inhibitory effects of CDH on MC mitogenesis. These findings suggest that CDH would inhibit the proliferation of rat MCs via the cAMP pathway.

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Effects Of NKH477 On Endothelin‐1‐Induced Renal Responses In Anaesthetized Dogs

Cited by 2 publications

References 11 publications

A Forskolin Derivative, Colforsin Daropate Hydrochloride, Inhibits the Decrease in Cortical Renal Blood Flow Induced by Noradrenaline or Angiotensin II in Anesthetized Rats

A Forskolin Derivative, Colforsin Daropate Hydrochloride, Inhibits the Decrease in Cortical Renal Blood Flow Induced by Noradrenaline or Angiotensin II in Anesthetized Rats

A Forskolin Derivative, Colforsin Daropate Hydrochloride, Inhibits Rat Mesangial Cell Mitogenesis via the Cyclic AMP Pathway

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