Effects of Noise Exposure on the Vestibular System: A Systematic Review

Stewart, Courtney E.; Holt, Avril Genene; Altschuler, Richard A.; Cacace, Anthony T.; Hall, Courtney D.; Murnane, Owen D.; King, W. M.; Akin, Faith W.

doi:10.3389/fneur.2020.593919

Cited by 41 publications

(32 citation statements)

References 71 publications

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“…Furthermore, lesions of the mammalian auditory efferent pathway accelerate age-related hearing loss ( Liberman et al, 2014 ), and reduces protection against loud noise exposure (reviewed in Lauer et al, 2021 ). Thus, we further speculate that lesions to the mammalian vestibular efferent pathway in mammals would accelerate age-related peripheral vestibular impairment ( Merchant et al, 2000 ; Lopez et al, 2005 ) and reduce protection against noise-induced damage (reviewed in Stewart et al, 2020 ).…”

Section: Future Directions and Conclusionmentioning

confidence: 95%

Differences in the Structure and Function of the Vestibular Efferent System Among Vertebrates

Cullen

Wei

2021

Front. Neurosci.

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The role of the mammalian vestibular efferent system in everyday life has been a long-standing mystery. In contrast to what has been reported in lower vertebrate classes, the mammalian vestibular efferent system does not appear to relay inputs from other sensory modalities to the vestibular periphery. Furthermore, to date, the available evidence indicates that the mammalian vestibular efferent system does not relay motor-related signals to the vestibular periphery to modulate sensory coding of the voluntary self-motion generated during natural behaviors. Indeed, our recent neurophysiological studies have provided insight into how the peripheral vestibular system transmits head movement-related information to the brain in a context independent manner. The integration of vestibular and extra-vestibular information instead only occurs at next stage of the mammalian vestibular system, at the level of the vestibular nuclei. The question thus arises: what is the physiological role of the vestibular efferent system in mammals? We suggest that the mammalian vestibular efferent system does not play a significant role in short-term modulation of afferent coding, but instead plays a vital role over a longer time course, for example in calibrating and protecting the functional efficacy of vestibular circuits during development and aging in a role analogous the auditory efferent system.

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Section: Future Directions and Conclusionmentioning

confidence: 95%

Differences in the Structure and Function of the Vestibular Efferent System Among Vertebrates

Cullen

Wei

2021

Front. Neurosci.

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“…Finally, potentially modifiable factors can also influence these mechanisms. Diet (Someya et al, 2010) and exercise (Han et al, 2016) influence ARHL, and exposure to ototoxins (Yang et al, 2015) and noise (Stewart et al, 2020) influence both acquired hearing loss and vestibular dysfunction (Figure 4).…”

Section: Overlapping and Interacting Mechanismsmentioning

confidence: 99%

Age-Related Changes in the Cochlea and Vestibule: Shared Patterns and Processes

2021

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Both age-related hearing loss (ARHL) and age-related loss in vestibular function (ARVL) are prevalent conditions with deleterious consequences on the health and quality of life. Age-related changes in the inner ear are key contributors to both conditions. The auditory and vestibular systems rely on a shared sensory organ – the inner ear – and, like other sensory organs, the inner ear is susceptible to the effects of aging. Despite involvement of the same sensory structure, ARHL and ARVL are often considered separately. Insight essential for the development of improved diagnostics and treatments for both ARHL and ARVL can be gained by careful examination of their shared and unique pathophysiology in the auditory and vestibular end organs of the inner ear. To this end, this review begins by comparing the prevalence patterns of ARHL and ARVL. Next, the normal and age-related changes in the structure and function of the auditory and vestibular end organs are compared. Then, the contributions of various molecular mechanisms, notably inflammaging, oxidative stress, and genetic factors, are evaluated as possible common culprits that interrelate pathophysiology in the cochlea and vestibular end organs as part of ARHL and ARVL. A careful comparison of these changes reveals that the patterns of pathophysiology show similarities but also differences both between the cochlea and vestibular end organs and among the vestibular end organs. Future progress will depend on the development and application of new research strategies and the integrated investigation of ARHL and ARVL using both clinical and animal models.

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“…The vestibular function evaluated with VsEP at 7 days after noise exposure showed no significant difference between the PQQ-treated group and the control group. The vestibular dysfunction after noise exposure was observed in previous studies withVsEP evaluation 54 , in which noise intensity ranged from 110 dB SPL 55 or 120 dB SPL 56 – 58 to 158 dB SPL 59 or 160 dB SPL 60 . The condition of noise used in the current study was within this range.…”

Section: Discussionmentioning

confidence: 64%

Effects of pyrroloquinoline quinone on noise-induced and age-related hearing loss in mice

Gao

Kamogashira

Fujimoto

et al. 2022

Sci Rep

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We investigated whether the oxidoreductase cofactor pyrroloquinoline quinone (PQQ) prevents noise-induced and age-related hearing loss (NIHL and ARHL) in mice. To assess NIHL, 8 week-old mice with and without PQQ administration were exposed to noise for 4 h. PQQ was orally administered for one week before and after noise exposure and subcutaneously once before noise exposure. For ARHL evaluation, mice were given drinking water with or without PQQ starting at 2 months of age. In the NIHL model, PQQ-treated mice had auditory brainstem response (ABR) thresholds of significantly reduced elevation at 8 kHz, a significantly increased number of hair cells at the basal turn, and significantly better maintained synapses beneath the inner hair cells compared to controls. In the ARHL model, PQQ significantly attenuated the age-related increase in ABR thresholds at 8 and 32 kHz at 10 months of age compared to controls. In addition, the hair cells, spiral ganglion cells, ribbon synapses, stria vascularis and nerve fibers were all significantly better maintained in PQQ-treated animals compared to controls at 10 months of age. These physiological and histological results demonstrate that PQQ protects the auditory system from NIHL and ARHL in mice.

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Effects of Noise Exposure on the Vestibular System: A Systematic Review

Cited by 41 publications

References 71 publications

Differences in the Structure and Function of the Vestibular Efferent System Among Vertebrates

Differences in the Structure and Function of the Vestibular Efferent System Among Vertebrates

Age-Related Changes in the Cochlea and Vestibule: Shared Patterns and Processes

Effects of pyrroloquinoline quinone on noise-induced and age-related hearing loss in mice

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