Objective: This study aims to assess the effects of noise pollution in Port Harcourt Metropolis and to determine its association with health, quality of life, and economic well-being of the people resident in the area.Methods: A cross-sectional survey involving 422 adult residents of Port Harcourt Metropolis was conducted. Participants completed a questionnaire assessing their physical and mental health, as well as their economic well-being. Statistical analysis including descriptive and inferential analysis were used to assess the effect of noise pollution on the physical, mental and economic well-being of the residents, as well as the relationships between variables.Results: The study reveals a mean noise level of 72.91dB in Port Harcourt Metropolis, highlighting the pervasive risk of annoyance and hearing damage. Findings indicate a low negative effect of noise pollution on the physical health (48%), moderate negative effect on both mental health and economic well-being 58% and 56% respectively, among residents of Port Harcourt Metropolis.Conclusion: The study concludes that while noise pollution in Port Harcourt Metropolis has a moderate effect on mental health and economic well-being, it has a low effect on physical health. Additionally, strong positive correlations are found between gender and both physical and mental health, with females showing a stronger association. Recommendations include implementing measures to mitigate noise pollution and addressing gender disparities to improve overall well-being in the area.