Effects of nomifensine in vitro on uptake of 5‐hydroxytryptamine and dopamine into human platelets.

Abstract

1The effect of nomifensine on the uptake of 5-hydroxytryptamine (5-HT) and dopamine (DA) into human platelet-rich plasma has been studied. 2 A significant inhibition of DA uptake was observed at nomifensine 10-6M. 3 5-HT uptake was significantly inhibited only at nomifensine 10-4M or more. 4 These results are consistent with those from previous animal experiments and suggest that the human platelet may be used as a model for studying DA uptake as well as that of 5-HT.

Enhanced attention in rhesus monkeys as a common factor for the cognitive effects of drugs with abuse potential

“…Nomifensine, an inhibitor of monoamine reuptake preferring the dopamine transporter (Ehsanullah and Turner 1977), while not a drug of abuse per se, has been found to be sufficiently reinforcing to establish lever-pressing behavior in rats (Carlezon et al 1995). Nomifensine competes with, and can displace cocaine for its binding site on the dopamine transporter (Missale et al 1985).…”

Platelet monoamine uptake in relatives of patients with Huntington’s chorea

“…A further 3 patients (2 males, one female) with established HC were matched with normal subjects, and platelet DA and 5-HT uptake was studied. Platelet monoamine uptake was measured by the method described elsewhere (Ehsanullah and Turner, 1977).…”

Nomifensine symposium: discussion after paper by R. Ehsanullah and P. Turner.

“…I would like to supplement the studies of Ehsanullah & Turner (1977) with some studies of my own regarding the effect of nomifensine on 5-hydroxytryptamine (5-HT) uptake in human blood platelets. Time does not allow me to describe the method in detail (see Lingjaerde, 1976).…”