Effects of non‐cytotoxic drugs on the growth of multidrug‐resistance human gastric carcinoma cell line

Wang, Chun H.; Zheng, Wen; Ou, Qiang; Tang, Chaowei

doi:10.1111/j.1751-2980.2009.00370.x

Cited by 4 publications

(1 citation statement)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Therefore, the identification of drug resistant cancer cells would be extremely helpful to provide an effective way to monitor progression of cancer diseases and facilitate the selection of efficient therapeutic strategies [106]. Previous studies indicated that the membrane properties and phospholipids of the cancer cells with MDR can be regulated by drugs [107–112]. In addition, as compared to the non-drug-resistant cancer cell lines, the MDR cancer cells also express different types and amounts of proteins in the membranes [113].…”

Section: Resultsmentioning

confidence: 99%

Pattern-based sensing of triple negative breast cancer cells with dual-ligand cofunctionalized gold nanoclusters

Tao

Auguste

2017

Biomaterials

View full text Add to dashboard Cite

Early detection of breast cancer is a critical component in patient prognosis and establishing effective therapy regimens. Here, we developed an easily accessible yet potentially powerful sensor to detect cancer cell targets by utilizing seven dual-ligand cofunctionalized gold nanoclusters (AuNCs) as both effective cell recognition elements and signal transducers. On the basis of this AuNC multichannel sensor, we have successfully distinguished healthy, cancerous and metastatic human breast cells with excellent reproducibility and high sensitivity. Triple negative breast cancer cells (TNBCs), which exhibit low expression of the estrogen receptor, progesterone receptor, and human epidermal growth factor receptor-2, were identified. The high accuracy of the blind breast cell sample tests further validates the practical application of the sensor array. In addition, the versatility of the sensor array is further justified by identifying amongst distinct cell types, different cell concentrations and cell mixtures. Notably, the drug-resistant cancer cells can also be efficiently discriminated. Furthermore, the dual-ligand cofunctionalized AuNCs can efficiently differentiate different cells from the peripheral blood of tumor-free and tumor-bearing mice. Taken together, this fluorescent AuNCs based array provides a powerful cell analysis tool with potential applications in biomedical diagnostics.

show abstract