Effects of Non-Pharmacological Treatments on Quality of Life in Parkinson’s Disease

Ahn, Sanghyun; Bredow, Tim; Yu, Fang

doi:10.1093/geroni/igx004.1184

Cited by 7 publications

(9 citation statements)

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“…The current therapy against PD relies both on pharmacological and nonpharmacological approaches with associated side effects. 50,51 However, the currently available therapy fails to halt degeneration of DA-ergic neurons and disease progression. Several pharmacological approaches involving both natural and/or synthetic compounds are being investigated for their therapeutic potential against PD.…”

Section: ■ Discussionmentioning

confidence: 99%

Piperine-Coated Gold Nanoparticles Alleviate Paraquat-Induced Neurotoxicity in Drosophila melanogaster

Anand

Fatima

Prajapati

et al. 2020

ACS Chem. Neurosci.

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Parkinson's disease (PD) is the most common progressive neurodegenerative disease known to impart bradykinesia leading to diverse metabolic complications. Currently, scarcity of effective drug candidates against this long-term devastating disorder poses a big therapeutic challenge. Here, we have synthesized biocompatible, polycrystalline, and uniform piperine-coated gold nanoparticles (AuNPs piperine ) to specifically target paraquat-induced metabolic complications both in Drosophila melanogaster and SH-SY5Y cells. Our experimental evidence clearly revealed that AuNPs piperine can effectively reverse paraquat-induced lethal effects in both in vitro and in vivo model systems of PD. AuNPs piperine were found to suppress oxidative stress and mitochondrial dysfunction, leading to inhibition of apoptotic cell death in paraquat-treated flies. AuNPs piperine were also found to protect SH-SY5Y cells against paraquat-induced toxicity at the cellular level preferably by maintaining mitochondrial membrane potential. Both experimental and computational data point to the possible influence of AuNPs piperine in regulating the homeostasis of parkin and p53 which may turn out to be the key factors in reducing PD symptoms. The findings of this work may facilitate the development of piperine-based nanoformulations against PD.

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Section: ■ Discussionmentioning

confidence: 99%

Piperine-Coated Gold Nanoparticles Alleviate Paraquat-Induced Neurotoxicity in Drosophila melanogaster

Anand

Fatima

Prajapati

et al. 2020

ACS Chem. Neurosci.

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“…Although LD decreases duration of FoG episodes and their frequency during on-medication periods, FoG incidents are still difficult to treat during off state and in advanced stages of the disease. On the other hand, drugs for non-motor symptoms can interfere with the effectiveness of LD and aggravate motor symptoms [14]. DA, in contrast with LD, may provoke more FoG episodes in early stages of disease [15].…”

Section: Introductionmentioning

confidence: 99%

Towards Real-Time Prediction of Freezing of Gait in Patients With Parkinson’s Disease: Addressing the Class Imbalance Problem

Naghavi

Miller

Wade

2019

Sensors

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Freezing of gait (FoG) is a common motor symptom in patients with Parkinson’s disease (PD). FoG impairs gait initiation and walking and increases fall risk. Intelligent external cueing systems implementing FoG detection algorithms have been developed to help patients recover gait after freezing. However, predicting FoG before its occurrence enables preemptive cueing and may prevent FoG. Such prediction remains challenging given the relative infrequency of freezing compared to non-freezing events. In this study, we investigated the ability of individual and ensemble classifiers to predict FoG. We also studied the effect of the ADAptive SYNthetic (ADASYN) sampling algorithm and classification cost on classifier performance. Eighteen PD patients performed a series of daily walking tasks wearing accelerometers on their ankles, with nine experiencing FoG. The ensemble classifier formed by Support Vector Machines, K-Nearest Neighbors, and Multi-Layer Perceptron using bagging techniques demonstrated highest performance (F1 = 90.7) when synthetic FoG samples were added to the training set and class cost was set as twice that of normal gait. The model identified 97.4% of the events, with 66.7% being predicted. This study demonstrates our algorithm’s potential for accurate prediction of gait events and the provision of preventive cueing in spite of limited event frequency.

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“…[15][16][17][18] Moreover, nonpharmacological treatment has been demonstrated to improve self-efficacy and emotional well-being. [19][20][21] Technology using virtual reality training (VRT) is a promising rehabilitation tool, as it can provide multisensory stimulation to create a realistic environment and improve the motivation and the adhesion of patients to the rehabilitation program. 6 Both commercial VR systems, such as Nintendo Wii or Xbox Kinect, and customized VR devices specifically designed to address PD symptoms have been used with positive results, especially on balance, reduction of the falls, and gait.…”

Section: Introductionmentioning

confidence: 99%

“…15 –18 Moreover, nonpharmacological treatment has been demonstrated to improve self-efficacy and emotional well-being. 19 –21…”

Section: Introductionmentioning

confidence: 99%

What About the Role of Virtual Reality in Parkinson Disease’s Cognitive Rehabilitation? Preliminary Findings From a Randomized Clinical Trial

Maggio

Cola

Latella

et al. 2018

J Geriatr Psychiatry Neurol

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Background: The purpose of this study is to evaluate the effects of a virtual reality training with BTS Nirvana (BTS-N) system in the cognitive and behavioral recovery in patients with Parkinson disease (PD). The BTS-N is a semi-immersive therapy system used for motor and cognitive rehabilitation of patients with neurological diseases, by creating virtual scenarios with which the patient may interact. Methods: We enrolled 20 patients with PD undergoing neurorehabilitation. All the patients were randomized into 2 groups: experimental group performing semi-immersive virtual reality training with BTS-N and control group undergoing traditional cognitive training. Each participant was evaluated before and immediately after the end of the training. Each cognitive training consisted of 3 sessions a week, each lasting 60 minutes, for 8 weeks, for a total of 24 sessions in each group. Results: Experimental group showed a greater improvement in cognitive functioning, with regard to executive and visuospatial abilities, as compared with the control group. Conclusion: Our findings suggest that rehabilitation through a new virtual reality instrument could be a valuable tool in improving cognitive and behavioral outcomes of patients with PD.

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Effects of Non-Pharmacological Treatments on Quality of Life in Parkinson’s Disease

Cited by 7 publications

References 0 publications

Piperine-Coated Gold Nanoparticles Alleviate Paraquat-Induced Neurotoxicity in Drosophila melanogaster

Piperine-Coated Gold Nanoparticles Alleviate Paraquat-Induced Neurotoxicity in Drosophila melanogaster

Towards Real-Time Prediction of Freezing of Gait in Patients With Parkinson’s Disease: Addressing the Class Imbalance Problem

What About the Role of Virtual Reality in Parkinson Disease’s Cognitive Rehabilitation? Preliminary Findings From a Randomized Clinical Trial

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