Effects of non‐selective non‐steroidal anti‐inflammatory drugs on the aggressiveness of prostate cancer

Stock, David; Groome, Patti A.; Rohland, Susan L.; Song, Zeqing

doi:10.1002/pros.20834

Cited by 15 publications

(28 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Unfortunately, we had no information on risk factors such as smoking, diet, obesity, or reproductive history in order to evaluate this finding. A growing body of evidence suggests that the widespread use of non-steroidal anti-inflammatory agents may have a protective effect on cancers of the breast, prostate, and uterus [53–58], which is another possible explanation for our results. The lower risks of hormone-related cancers could also be related to endogenous hormone levels, which have also been implicated in RA risk and disease severity [59–62].…”

Section: Discussionmentioning

confidence: 76%

Risk of cancer among rheumatoid arthritis patients in California

Parikh‐Patel

White

Allen

et al. 2009

Cancer Causes Control

View full text Add to dashboard Cite

Objective The objective of this retrospective cohort study was to evaluate cancer risk among rheumatoid arthritis (RA) patients in California. Methods The study cohort derived from statewide patient discharge records was followed via linkage with cancer registry data over the period 1991–2002. Age and sex adjusted standardized incidence ratios (SIRs) and 95% confidence intervals were calculated to compare observed to expected numbers of cancers based on age, race, and sex specific incidence rates in the California population. Results Among the 84,475 RA patients, who were observed for 405,540 person-years, 5,533 incident cancers were diagnosed during the observation interval. The risk of developing lymphohematopoietic cancer was significantly higher in the cohort for both sexes. Males had significantly higher risks of lung, liver, and esophageal cancer, but a lower risk of prostate cancer. Females were at significantly decreased risk for several cancers including breast, ovary, uterus, cervix, and melanoma, with the risk reduction ranging from 15 to 57% lower than the general population. Hispanics had increased risks of leukemia, vagina/vulva, lung, and liver cancers. Conclusion Studies investigating the mechanisms that underlie the reported associations between RA and specific cancer types are needed.

show abstract

Section: Discussionmentioning

confidence: 76%

Risk of cancer among rheumatoid arthritis patients in California

Parikh‐Patel

White

Allen

et al. 2009

Cancer Causes Control

View full text Add to dashboard Cite

show abstract

“…The studies that met the inclusion criteria were all observational studies, comprising 20 case–control [9-11,16,17,21-23,26,28-33,35-37,41],[44] and 19 cohort studies [7,8,12-15,18-20,24,25,27,34],[39,40,42,43,45,46] involving more than 924,502 male subjects, including 108,136 PCa cases. Thirty-one studies (18 case–control [9-11,16,17,21-23,26,28-33,35-37] and 13 cohort [7,8,12-15,18-20,24,25,27,34]) addressed the use of any NSAID and its association with PCa incidence risk (Table 1); eight studies (two case–control [41,44] and six cohort [39,40,42,43,45,46]) investigated whether NSAID use was associated with PCa-specific mortality (Table 2).…”

Section: Resultsmentioning

confidence: 99%

“…Thirty-one studies (18 case–control [9-11,16,17,21-23,26,28-33,35-37] and 13 cohort [7,8,12-15,18-20,24,25,27,34]) addressed the use of any NSAID and its association with PCa incidence risk (Table 1); eight studies (two case–control [41,44] and six cohort [39,40,42,43,45,46]) investigated whether NSAID use was associated with PCa-specific mortality (Table 2). For NSAID use and PCa incidence risk, the publication dates of the studies ranged between 1989 and 2014.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Effect of aspirin and other non-steroidal anti-inflammatory drugs on prostate cancer incidence and mortality: a systematic review and meta-analysis

Liu

Chen

Xie

et al. 2014

BMC Med

View full text Add to dashboard Cite

BackgroundIt has been postulated that non-steroidal anti-inflammatory drugs (NSAIDs) use leads to decreased prostate cancer (PCa) risk. In recent years, NSAIDs’ role in PCa development has been extensively studied; however, there is not yet a definitive answer. Moreover, the epidemiological results for NSAIDs’ effect on PCa-specific mortality have been inconsistent. Therefore, we performed a meta-analysis to examine the controversy.MethodsWe performed a literature database search and included all published studies conducted in the general population exposed to any NSAID, extracting an odds ratio (OR) or a hazard ratio (HR) with 95% confidence intervals (95% CIs) that compared the incidence of PCa or PCa-specific mortality with non-exposure. We derived a pooled OR or HR using random or fixed effects models, as appropriate. Subgroup analyses were also performed.ResultsThirty-nine studies (20 case–control and 19 cohort studies) were included in this analysis. Thirty-one studies were available concerning NSAID use and PCa incidence and eight studies on PCa-specific mortality. Compared to non-use, aspirin use was statistically significantly associated with PCa incidence risk, and the association was slightly stronger for advanced PCa than for total PCa (OR = 0.92, 95% CI = 0.87 to 0.97 for total PCa; OR = 0.81, 95% CI = 0.73 to 0.89 for advanced PCa). Aspirin use seems also to be associated with a modest reduction in PCa-specific mortality (HR = 0.86, 95% CI = 0.78 to 0.96 for total PCa; OR = 0.81, 95% CI = 0.71 to 0.92 for advanced PCa). Generally, the pooled effects for any NSAIDs, NA-NSAIDs and cyclooxygenase-2 inhibitors demonstrated no adverse or beneficial effects on PCa development or PCa-specific mortality, but the results were not consistent. The effect estimates did not vary markedly when stratified by study design and study quality but varied by geographic region. Furthermore, long-term aspirin use (≥4 years) was also significantly associated with reduced PCa incidence (OR = 0.88, 95% CI 0.79 to 0.99).ConclusionsThe present meta-analysis provides support for the hypothesis that aspirin use is inversely related to PCa incidence and PCa-specific mortality. The effect estimates, varying by geographic region, deserve further investigation.

show abstract

“…40,41 In a phase II study, Pruthi and colleagues 42 showed a slowing effect of COX inhibitor celecoxib on the rate of prostatespecific antigen (PSA) rise after biochemical failure of local treatment of prostatic carcinoma. These findings have brought up the possibility of using anti-inflammatory drugs as a means of preventing this disease.…”

Section: Discussionmentioning

confidence: 99%

Nonsteroidal anti-inflammatory drugs and prostate cancer: a systematic review of the literature and meta-analysis

Jafari

Etminan

Afshar

2013

CUAJ

View full text Add to dashboard Cite

Prostate cancer is the most common visceral cancer in men. Many studies have shown that nonsteroidal anti-inflammatory drugs (NSAIDs) may reduce the risk of prostate cancer. We systematically searched all relevant databases (MEDLINE, EMBASE, The Cochrane Collaboration, CINAHL, Database of Abstracts of Review of Effects and ACP Journal Club) to March 2008. We also explored bibliographies of the articles, pertinent journals and conferences. We selected relevant articles according to predefined inclusion criteria by 2 independent reviewers. We used both fixed and randomeffect models for meta-analysis. We performed subgroup and sensitivity analysis based on predefined variables. From 962 extracted articles, 20 met the inclusion criteria with a total of 25 768 participants. All the studies had an observational design. There was a statistically significant protective effect for NSAIDs on risk of prostate cancer (odds ratio [OR] 0.92, 95% confidence interval [CI] 0.86-0.97). Subgroup analysis did not show any effect of study design or quality score on the results. There was a small but statistically significant protective effect for acetylsalicylic acid (ASA) (OR 0.95, 95% CI 0.91-1.00). Exposure to non-ASA NSAIDs was associated with a slightly reduced likelihood of prostate cancer (OR 0.92, 95% CI 0.85-1.00). With the available data, we were not able to determine an optimum dosage for NSAIDs. We conclude that taking NSAIDs may reduce the risk of prostate cancer. Nevertheless, the effect is small. RésuméLe cancer de la prostate est le cancer viscéral le plus fréquent chez l'homme. Bon nombre d'études ont montré que les antiinflammatoires non stéroïdiens (AINS) pouvaient réduire le risque de cancer de la prostate. Notre objectif était de réaliser une revue systématique et une méta-analyse des articles publiés sur les effets des AINS dans la réduction du risque de cancer de la prostate. On a noté un effet protecteur statistiquement significatif sur le risque de cancer de la prostate avec les AINS (rapport de cotes de 0,92; IC à 95 % de 0,86 à 0,97). L'analyse par sous-groupes n'a révélé aucun effet du plan de l'étude ou du score de qualité sur les résultats. On a noté un effet protecteur léger mais tout de même significatif sur le plan statistique avec l'aspirine (RC 0,95; IC à 95 % de 0,91 à 1,00). L'exposition à des AINS autres que l'aspirine a été associée à une probabilité légèrement moindre de cancer de la prostate (RC 0,92, IC à 95 % de 0,85 à 1,00). Les données disponibles ne nous ont pas permis de déterminer la posologie optimale des AINS. Nous avons observé un effet favorable possible associé à la prise d'AINS dans la réduction du risque de cancer de la prostate, mais cet effet est minime.

show abstract

Effects of non‐selective non‐steroidal anti‐inflammatory drugs on the aggressiveness of prostate cancer

Abstract: Although estimates were not statistically significant, this exploratory study indicates a possible negative association between NSAID use and disease aggressiveness. Larger investigations with more precise exposure measurements are recommended.

Cited by 15 publications

References 20 publications

Risk of cancer among rheumatoid arthritis patients in California

Risk of cancer among rheumatoid arthritis patients in California

Effect of aspirin and other non-steroidal anti-inflammatory drugs on prostate cancer incidence and mortality: a systematic review and meta-analysis

Nonsteroidal anti-inflammatory drugs and prostate cancer: a systematic review of the literature and meta-analysis

Contact Info

Product

Resources

About