Effects of non-surgical periodontal therapy on serum lipids and C-reactive protein among hyperlipidemic patients with chronic periodontitis

Tawfig, Ahmed

doi:10.4103/2231-0762.156524

Cited by 13 publications

(9 citation statements)

References 44 publications

(54 reference statements)

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“… 34 Inversely, previous studies have shown that the treatment for periodontitis lowers the levels of inflammatory markers. 35 , 36 As such, both UAE and periodontitis are commonly related to persistent inflammation that may lead to vascular endothelial dysfunction. They may also be interrelated bidirectionally and deleteriously affect each other.…”

Section: Discussionmentioning

confidence: 99%

Association of Periodontitis With Urinary Albumin Excretion in Korean Adults With Diabetes

Han

Nam

Kim³

et al. 2015

Medicine

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Albuminuria and periodontitis are both commonly associated with systemic inflammation. However, the association between urinary albumin excretion (UAE) and periodontitis in patients with type 2 diabetes has not been fully investigated. This study aimed to investigate the association between UAE and periodontitis in Korean adults with type 2 diabetes.This study performed a cross-sectional analysis and used hierarchical multivariable logistic regression analysis models. Data from the 2012 Korean National Health and Nutrition Examination Survey were analyzed. A total of 547 patients, with type 2 diabetes without renal impairment, were included in this study. UAE was assessed using the urinary albumin to creatinine ratio (UACR). A community periodontal index greater than or equal to code 3 was used to define periodontitis.The risk of periodontitis tended to increase as UACR increased even after adjustment for potential confounders (P for trend in the odds ratios = .05 in model 1; 0.02 in model 2; and 0.01 in model 3). In a subgroup analysis, the prevalence of periodontitis was significantly higher in the patients with albuminuria (UACR >30 mg/g) than in those without albuminuria among patients younger than 65 years (P = .03), those with newly diagnosed diabetes (P = .04), or those without obesity (P = .04).UAE was positively associated with the risk of periodontitis in Korean adults with type 2 diabetes. In the patients who were younger, were newly diagnosed with diabetes, or had normal body mass index, individuals with albuminuria were more likely to have a higher prevalence of periodontitis. Early identification of periodontitis may be helpful in Korean diabetic adults with increased UAE.

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Section: Discussionmentioning

confidence: 99%

Association of Periodontitis With Urinary Albumin Excretion in Korean Adults With Diabetes

Han

Nam

Kim³

et al. 2015

Medicine

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“…The translocation of bacteria and bacterial products of oral cavity can induce a systemic inflammatory process, characterized by high levels of pro-inflammatory cytokines, including increased levels of CRP ( 4 ). CRP has also been considered a significant risk factor for many systemic diseases, such as cardiovascular disease and type 2 diabetes ( 3 , 5 ).…”

Section: Introductionmentioning

confidence: 99%

Association between periodontitis and serum c-reactive protein levels

et al. 2020

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Background Periodontal disease may be associated with more bacteria and consequent induction of a systemic inflammatory process, with changes in the levels of C-reactive protein (CRP). The purpose of this cross-sectional study was to evaluate the association between periodontitis and serum levels of C-reactive protein. Material and Methods The sample comprised 100 individuals distributed into two groups according to serum levels of C-reactive protein: normal or altered. Social, biological and behavioral data were collected by means of a structured questionnaire. Additionally, a blood test was requested to measure C-reactive protein levels. CRP values less than 3 mg/l were considered normal. Periodontal clinical examination was conducted in each participant for analysis of probing depth, bleeding on probing and clinical attachment level. Descriptive statistics, univariate analysis and logistic regression were performed. Results were provided in odds ratio, confidence intervals and p values. Results Individuals with altered C-reactive protein levels showed a higher prevalence of periodontitis than individuals with normal C-reactive protein levels ( p =0.008). In the final logistic regression model, individuals with periodontitis were more likely to present altered C-reactive protein than individuals without periodontitis (OR=3.27, CI=1.42-7.52, p =0.005). Conclusions The alteration of the C-reactive protein levels among individuals with a higher prevalence of periodontitis corroborates clinical evidence that periodontal infection has a systemic impact. Key words: C-reactive protein, cytokines, periodontal diseases, periodontitis.

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“…A relationship between periodontal disease and atherosclerosis has been recognized in epidemiological studies (Lockhart et al 2012 ). Periodontitis can elicit endothelial dysfunction, oxidative stress, and lipid accumulation in the aorta (Abe and Hajishengallis 2013 ; Miyajima et al 2014 ; Brito et al 2013 ); in addition, nonsurgical periodontal therapy (NSPT), scaling and root planing (SRP) primarily, improved lipid status and decreased systemic inflammatory response (Tawfig 2015 ; D’Aiuto et al 2006 ; Hada et al 2015 ). For example, SRP decreased serum tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and C-reaction protein (CRP) levels in chronic periodontitis subjects with stable coronary heart disease (Tawfig 2015 ).…”

Section: Introductionmentioning

confidence: 99%

“…Periodontitis can elicit endothelial dysfunction, oxidative stress, and lipid accumulation in the aorta (Abe and Hajishengallis 2013 ; Miyajima et al 2014 ; Brito et al 2013 ); in addition, nonsurgical periodontal therapy (NSPT), scaling and root planing (SRP) primarily, improved lipid status and decreased systemic inflammatory response (Tawfig 2015 ; D’Aiuto et al 2006 ; Hada et al 2015 ). For example, SRP decreased serum tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and C-reaction protein (CRP) levels in chronic periodontitis subjects with stable coronary heart disease (Tawfig 2015 ). Intensive periodontal therapy (SRP followed by the adjunctive use of a locally delivered antimicrobial) reduced systemic inflammatory markers and systolic blood pressure, and improved lipid profiles with subsequent changes in cardiovascular risk (D’Aiuto et al 2006 ).…”

Section: Introductionmentioning

confidence: 99%

Nonsurgical periodontal treatment reduced aortic inflammation in ApoE−/− mice with periodontitis

Cui

Lei

et al. 2016

SpringerPlus

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BackgroundAlthough the correlation between periodontal infection and atherosclerotic lesions has been well recognized, whether and how the nonsurgical periodontal treatment (NSPT) can improve the vascular inflammation has not been investigated clearly.MethodsThirty-two apolipoprotein E−/− (apoE−/−) mice were randomly divided into four groups: (1) Con group: no treatment, blank control group; (2) Lig group: ligature-induced-periodontitis group; (3) Lig-N group: ligatures were removed on the 7th day; (4) Lig-SRP group: ligatures were removed on the 7th day, and scaling and root planing (SRP) were performed on the 9th day. All the animals were euthanized on the 30th day. Alveolar bone loss (ABL) was assessed under microcomputed tomography. Systemic inflammatory status and lipid contents in the plasma were detected. Expression of several surrogate markers for vascular inflammation was evaluated by immunohistology and quantitative real time PCR.ResultsNSPT reduced ABL, improved lipid profile, and inhibited systemic inflammation with reduced plasma interleukin-6 (IL-6) level in apoE−/− mice; in addition, reduced inflammation in arterial wall was observed in NSPT treated mice, showing less vascular cell adhesion molecule-1 expression and less macrophage adhesion; furthermore, NSPT improved elastic fiber fragmentation disorder in the aortic wall, thus preserved elasticity of aortic artery.ConclusionLigature-induced periodontitis can lead to inflammatory response in the vascular wall and NSPT has beneficial effect on the early stage of atherosclerosis process in the articular wall by reducing systemic inflammation and improving lipid profile.

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Effects of non-surgical periodontal therapy on serum lipids and C-reactive protein among hyperlipidemic patients with chronic periodontitis

Cited by 13 publications

References 44 publications

Association of Periodontitis With Urinary Albumin Excretion in Korean Adults With Diabetes

Association of Periodontitis With Urinary Albumin Excretion in Korean Adults With Diabetes

Association between periodontitis and serum c-reactive protein levels

Nonsurgical periodontal treatment reduced aortic inflammation in ApoE−/− mice with periodontitis

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