Effects of Non-surgical Periodontal Therapy on Saliva and Gingival Crevicular Fluid Levels of Chemerin in Periodontitis Subjects With and Without Type 2 Diabetes Mellitus

GD, Gomathi; Gopalakrishnan, S; Sudhakar, Uma; Raghavan, Anusha; Narayan, Keerthi V

doi:10.7759/cureus.33388

Cited by 3 publications

(3 citation statements)

References 19 publications

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“…The description of non-diabetes varied among the studies included in this review. More than half of the studies (19/34) defined non-diabetics subjects as systematically healthy individuals or those without a diagnosis of DM [36,37,[39][40][41][45][46][47]51,52,[58][59][60][63][64][65][66][67][68]. Furthermore, the glycemic test parameters and cut-off values varied from 6% to 6.5% for HbA1c [35,43,[48][49][50]53,[55][56][57]61,76], 100 to 126 mg/dl for FPG [35,38,42,44,48,50], and 140 to 200 mg/mL for RBS [43,56,62].…”

Section: Discussionmentioning

confidence: 99%

“…The definitions of periodontitis differed among the studies included in this review (Table 1). The American Academy of Periodontology (AAP) 1999 classification was used to diagnose periodontitis in 20 (58.8%) studies, whereas 4 studies [35,58,59,61] used the American Academy of Periodontology and European Federation of Periodontology (AAP/EFP) 2017 classification; meanwhile, 2 studies [37,38] used the Community Periodontal Index (CPI), and in 1 study [50], the disease was diagnosed based on the criteria from the Center for Disease Control and Prevention and the American Academy of Periodontology (CDC/AAP). Six sites per tooth were examined in more than half of the studies, whereas four sites per tooth were examined in two studies [47,66].…”

Section: Study Characteristicsmentioning

confidence: 99%

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Association between Periodontitis and HbA1c Levels in Non-Diabetic Patients: A Systematic Review and Meta-Analysis

Zhao,

Sun,

et al. 2023

Healthcare

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Background: A high detection rate of diabetes among dental visitors has been reported recently. This systematic review aimed to evaluate the association between periodontitis and glycated hemoglobin (HbA1c) levels among non-diabetic individuals. Methods: The EMBASE, MEDLINE, Web of Science, Cochrane Library, PubMed, and Open GREY databases were searched, and observational studies published until 1st June 2023 were identified. A methodological quality assessment was conducted based on the original and modified versions of the Newcastle–Ottawa scale. Cohort, case–control, and cross-sectional studies that performed clinical periodontal examinations and measured HbA1c levels in non-diabetic adults were included. A meta-analysis was conducted to estimate the weighted mean difference (WMD) between individuals with and without periodontitis. Results: In total, 29 case–control and 5 cross-sectional studies were selected from 2583 potentially eligible articles. Among them, sixteen case–control and three cross-sectional studies with moderate to high quality were selected for the meta-analyses. The HbA1c levels in periodontitis patients were significantly higher than those in individuals with healthy periodontal conditions (WMD = 0.16; p < 0.001) among the non-diabetic populations. Conclusions: This study reveals a significant association between periodontitis and HbA1c levels in non-diabetic populations. Thus, HbA1c screening may be recommended to detect potential hyperglycemia in non-diabetic periodontitis patients.

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Section: Discussionmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

Association between Periodontitis and HbA1c Levels in Non-Diabetic Patients: A Systematic Review and Meta-Analysis

Zhao,

Sun,

et al. 2023

Healthcare

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“…Systemic administration offers the potential benefit of effectively targeting pathogens that have spread extensively throughout the oral cavity, including those in non-dental oral areas, such as the tongue's upper surface and the tonsils' crevices. Still, it requires a lot of patients to follow through with their treatment, can introduce unwanted systemic side effects that can make it harder for patients to do so, and may help bacteria become more resistant [7][8][9]. On the other hand, local administration is not influenced by patient adherence.…”

Section: Introductionmentioning

confidence: 99%

Comparative Study of Systemic vs. Local Antibiotics with Subgingival Instrumentation in Stage III–IV Periodontitis: A Retrospective Analysis

Ilyes,

Boariu,

Rusu

et al. 2024

Antibiotics

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To improve the clinical and microbiological outcomes of non-surgical mechanical periodontal therapy, the adjunctive use of antimicrobials has been utilized in treating moderate-to-severe periodontitis. In our study, the retrospective design included previously collected health-related patient data, obtained from the printed and digital charts of patients who received systemic or local antibiotic adjuncts to SI (subgingival instrumentation). A total of 34 patients (diagnosed with generalized Stage III/IV periodontitis) met the inclusion and exclusion criteria and were evaluated. The samples were tested for the following bacterial strains: Aggregatibacter actinomycetemcomitans (A. actinomycetemcomitans), Porphyromonas gingivalis (P. gingivalis), Prevotella intermedia (P. intermedia), Tanererella forsythia (T. forsythia), and Treponema denticola (T. denticola). The inter-group comparisons of the bacterial species did not show statistically significant differences between groups. The present study aimed to evaluate the clinical effects after SI and the adjunctive use of systemically administered (SA) AMX (amoxicillin) + MET (metronidazole) (administered for 7 days), with locally delivered (LDD) piperacillin + tazobactam in step 2 of periodontal therapy. Results: Overall, all parameters were improved in the groups, with a significant difference in inter-group comparison regarding the full-mouth bleeding score (FMBS) (p < 0.05) in favor of the SA group, and the p-value < 0.05 was considered to be statistically significant. Statistically significant PPD (probing pocket depth) reductions and CAL (clinical attachment level) gains were observed in both groups at the 3-month follow-up. In conclusion, within the limitations, the outcomes of this study suggest that SI, with adjunctive local or systemic antibiotic therapy, provided comparable clinical improvements. Systemic AMX + MET protocols were more efficacious with regard to the reduction in FMBS. Follow-up studies with larger patient numbers are needed to further investigate this effect.

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Evaluation of the Effect of Routine Periodontal Treatment (SRP and Oral Hygiene Instruction) on Salivary Characteristics and Blood Sugar Control in Diabetic Patients: A Clinical Trial

Ahadian,

Mohiti,

Ghadiri Anari

et al. 2024

Journal of Kerman University of Medical Sciences

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Background: Diabetes mellitus is quite prevalent and causes many complications in different parts of the body. It also affects the quality of life by causing many complications in the oral cavity. This study examined a simple intervention to improve oral and periodontal tissue health and investigate its effect on the patient›s salivary characteristics and blood sugar control. Methods: This double-blind clinical trial was performed on 40 patients with type 2 diabetes. Fasting blood sugar (FBS), glycated hemoglobin (HbA1C), salivary glucose, amylase, total protein, viscosity, and pH were evaluated before and after scaling and oral hygiene instructions. The obtained data were entered into SPSS 17 statistical software and analyzed using the t-test, MannWhitney, and chi-square tests. Results: After the intervention, the FBS results in both groups (P value=0.015 in the case group and P value=0.017 in the control group) and HbA1C in the case group (P value=0.006) decreased significantly. Also, the difference in salivary viscosity, pH, and glucose between the case group and the control group was significant (P value=0.005, 0.008, and 0.021, respectively). Conclusion: Based on the results of the present study, scaling, and oral hygiene instructions reduce FBS and HbA1C, salivary glucose and amylase and oral conditions, leading to good blood sugar control.

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Effects of Non-surgical Periodontal Therapy on Saliva and Gingival Crevicular Fluid Levels of Chemerin in Periodontitis Subjects With and Without Type 2 Diabetes Mellitus

Cited by 3 publications

References 19 publications

Association between Periodontitis and HbA1c Levels in Non-Diabetic Patients: A Systematic Review and Meta-Analysis

Association between Periodontitis and HbA1c Levels in Non-Diabetic Patients: A Systematic Review and Meta-Analysis

Comparative Study of Systemic vs. Local Antibiotics with Subgingival Instrumentation in Stage III–IV Periodontitis: A Retrospective Analysis

Evaluation of the Effect of Routine Periodontal Treatment (SRP and Oral Hygiene Instruction) on Salivary Characteristics and Blood Sugar Control in Diabetic Patients: A Clinical Trial

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