Effects of Non‐Surgical Periodontal Treatment on Clinical Response, Serum Inflammatory Parameters, and Metabolic Control in Patients With Type 2 Diabetes: A Randomized Study

Chen, Lei; Luo, Gang; Xuan, Dongying; Wei, Bihong; Liu, Fang; Li, Jing; Zhang, Jincai

doi:10.1902/jop.2011.110327

Cited by 140 publications

(218 citation statements)

References 42 publications

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“…These results are consistent with those from previous studies in which the effect of FM-SRP, subgingival curettage, and tooth cleaning treatments on glycaemic control has been evaluated [26,[29][30][31][32].…”

Section: Discussionsupporting

confidence: 92%

Impact of combined non-surgical and surgical periodontal treatment in patients with type 2 diabetes mellitus-a preliminary report randomized clinical study

Bukleta¹,

Krasniqi²,

Beretta³

et al. 2018

biomedicalresearch

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Section: Discussionsupporting

confidence: 92%

Impact of combined non-surgical and surgical periodontal treatment in patients with type 2 diabetes mellitus-a preliminary report randomized clinical study

Bukleta¹,

Krasniqi²,

Beretta³

et al. 2018

biomedicalresearch

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“…These results are in line with other three clinical studies (Correa et al 2010, Duarte et al 2010, Sun et al 2011) describing the effect of periodontal therapy in individuals suffering also from other co-morbidities including diabetes. An equal number of trials failed to show a statistically significant effect of periodontal therapy on TNF-a (Ide et al 2003, Lalla et al 2007, Kallio et al 2008, Buhlin et al 2009, Fentoglu et al 2011, Chen et al 2012. Lastly, Fokkema et al (2003) investigated the long-term effect of full-mouth tooth extraction therapy on the responsiveness of peripheral blood monocytes in a single subject with generalized terminal adult periodontitis reporting no changes in TNF-a release before and after therapy.…”

Section: Cytokinesmentioning

confidence: 99%

Evidence that periodontal treatment improves biomarkers and CVD outcomes

D’Aiuto

Orlandi

Gunsolley

2013

Journal of Periodontology

128

137

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Evidence that periodontal treatment improves biomarkers and CVD outcomes D'Aiuto F, Orlandi M, Gunsolley JC. Evidence that periodontal treatment improves biomarkers and CVD outcomes. AbstractAim: The aim of this review was to critically appraise the evidence on the impact of periodontal treatment of cardiovascular diseases (CVDs) biomarkers and outcomes. Methods: A systematic search was performed in Cinhal, Cochrane, Embase and Medline for relevant articles up to July 2012. Duplicate screening and reference hand searching were performed. Data were then summarized and evidence graded in tables. Results: The search resulted in: (a) no evidence on the effects of periodontal therapy on subclinical atherosclerosis, serum levels of CD40 ligand, serum amyloid A and monocyte chemoattractant protein-1, (b) limited evidence on the effects of periodontal therapy on arterial blood pressure, leucocyte counts, fibrinogen, tissue necrosis factor-a, sE-selectin, von Willebrand factors, d-dimers, matrix metalloproteinases, oxidative stress and CVD events, and (c) moderate evidence suggesting a negligible effect of periodontal therapy in reducing interleukin-6 and lipids levels, whilst a positive effect in reducing serum C-reactive protein levels and improving endothelial function. Conclusions: Periodontal therapy triggers a short-term inflammatory response followed by (a) a progressive and consistent reduction of systemic inflammation and (b) an improvement in endothelial function. There is however limited evidence that these acute and chronic changes will either increase or reduce CVD burden of individuals suffering from periodontitis in the long term.

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“…15,16 The role of periodontal treatment in serum inflammatory markers is somewhat conflicting, possibly because of differences in periodontal therapy protocols (time of follow-up and use of local/systemic antimicrobials). Some studies have shown considerable changes in the serum levels of IL-6 and TNF-α, 17,18 whereas others have disclosed no significant changes in TNF-α, 19 20 and IL-8. 21 To the best of our knowledge, there is no information regarding the effect of strict supragingival biofilm control on inflammatory burden.…”

Section: Introductionmentioning

confidence: 99%

Supragingival biofilm control and systemic inflammation in patients with type 2 diabetes mellitus

et al. 2015

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The objective of this study was to evaluate the effect of strict supragingival biofilm control on serum inflammatory markers and on periodontal clinical parameters in type 2 diabetes mellitus (T2DM) patients with chronic severe periodontitis. Twenty-four individuals with T2DM and periodontitis were randomly allocated to two treatment groups. The supragingival therapy group (ST, n = 12) received supragingival scaling, whereas the intensive therapy group (IT, n = 12) underwent supra-and subgingival scaling, as well as root planing. Patients from both groups received professional oral hygiene instructions every month. Data regarding visible plaque index (VPI), gingival bleeding index (GBI), bleeding on probing (BOP), probing pocket depth (PPD), clinical attachment level (CAL), serum levels of interleukin (IL)-6, IL-17A, IL-8, tumor necrosis factor α (TNF-α), monocyte chemoattractant protein (MCP)-1 enzyme-linked immunosorbent assay (ELISA), and glycated hemoglobin (HbA1c) levels were obtained at baseline and at 6 months post-therapy. Both therapies resulted in the improvement of almost all clinical periodontal parameters (p < 0.05). There were no differences in TNF-α, IL-8, IL-17A and HbA1c levels in either group (p > 0.05), between the two periods. However, MCP-1 levels were significantly reduced in both the ST (p = 0.034) and the IT (p = 0.016) groups, whereas the serum IL-6 levels were significantly reduced only in the IT group (p = 0.001). Strict control of supragingival biofilm has a limited effect on systemic inflammatory markers, and a moderate effect on periodontal clinical parameters.

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Effects of Non‐Surgical Periodontal Treatment on Clinical Response, Serum Inflammatory Parameters, and Metabolic Control in Patients With Type 2 Diabetes: A Randomized Study

Abstract: Non-surgical periodontal treatment can effectively improve periodontal and circulating inflammatory status. Despite a lack of strong evidence, trends in some results support improved glycemic control after periodontal treatment in patients with diabetes.

Cited by 140 publications

References 42 publications

Impact of combined non-surgical and surgical periodontal treatment in patients with type 2 diabetes mellitus-a preliminary report randomized clinical study

Impact of combined non-surgical and surgical periodontal treatment in patients with type 2 diabetes mellitus-a preliminary report randomized clinical study

Evidence that periodontal treatment improves biomarkers and CVD outcomes

Supragingival biofilm control and systemic inflammation in patients with type 2 diabetes mellitus

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