Effects of non-surgical treatment of chronic periodontitis on insulin resistance and glucose tolerance in subjects without diabetes (PARODIA 2 study)

Abstract

This study aimed to assess the effects of non-surgical periodontal treatment (NSPT) of chronic periodontitis on insulin sensitivity, glucose tolerance, and serum C reactive protein (CRP) level in individuals without diabetes. Twenty individuals without diabetes with chronic periodontitis underwent NSPT, which consisted of complete scaling, polishing, root planing, and irrigation of the periodontal pockets with a 10% povidone-iodine solution. Periodontal indices (plaque index, gingival bleeding index, pocket depth, and clinical attachment loss), insulin sensitivity using the Short Insulin Tolerance Test index (KITT), glucose tolerance derived from oral glucose tolerance test, and serum CRP level were measured before and 3 months after the intervention. This study was carried out at the National Obesity Center of Yaoundé Central Hospital, Cameroon. After 3 months, we observed significant improvement in periodontal parameters (all p<0.001) and insulin sensitivity (3.72 (2.99–4.17) %/min before treatment vs 4.04 (3.67–4.78) %/min after treatment, p=0.001) and significant decrease in serum CRP level (2.35 (1.46–4.18) mg/L before vs 1.53 (1.03–2.12) mg/L after, p=0.033). There was a trend toward improvement in glucose tolerance, although not statistically significant after the intervention. This study suggests that NSPT of chronic periodontitis in individuals without diabetes is associated with increased insulin sensitivity and decreased serum CRP levels.Trial registration number NCT02830113.

Role of Nonalcoholic Fatty Liver Disease in Periodontitis: A Bidirectional Relationship

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Comparing the activity level of salivary matrix metalloproteinase‐8 in patients with diabetes and moderate to severe chronic generalized periodontitis

“…Those with periodontitis and type 2 diabetes have more inflammatory mediators in their saliva and gingival crevicular fluid than nondiabetic periodontitis patients (Chapple & Genco, 2013 ). Studies show that treating periodontitis can improve control over blood sugar levels and reduce resistance to insulin in diabetic patients (Nana et al, 2021 ; Santonocito et al, 2022 ; Teeuw et al, 2010 ).…”

Analysis of influencing factors of anxiety and depression in patients with periodontitis

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