“…Acupuncture has been documented to have many actions throughout the body including 1) deactivation of the limbic-paralimbic-neocorticol network system, which among other things is responsible for the perception of sensory pain 11,12 ; 2) activation of mu opioid receptors 13,14 ; 3) increase in serum  endorphins 15-17 ; 4) increase in adrenocorticotropic hormone (ACTH) release from the anterior pituitary, thus decreasing pain 15,18 ; 5) downregulation of M1 macrophages, Interleukin-1, Interleukin-6, Interleukin-18, and tumor necrosis factor (TNF), which have inflammatory functions 15,17,19-21 ; 6) upregulation of M2 macrophages, which have anti-inflammatory functions and increase immune system function of phagocytes, lymphocytes, T cells, B cells, and NK cells 15,17,19 ; and 7) during labor, stimulation of release of oxytocin from the posterior pituitary. 15,22 It is presumed by researchers and those practicing acupressure that the mechanisms of acupressure and acupuncture are similar.…”