2005
DOI: 10.1128/jvi.79.9.5353-5362.2005
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Effects of Nonstructural Proteins NS1 and NS2 of Human Respiratory Syncytial Virus on Interferon Regulatory Factor 3, NF-κB, and Proinflammatory Cytokines

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Cited by 252 publications
(260 citation statements)
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“…RSV DNS1 and DNS2 viruses exhibited delayed growth 24 h postinfection (p.i.) due to an inability to counter the host innate immune response, as has been reported previously (Spann et al, 2005). As the opposite phenotypes occurred with NS1 deficiency versus overexpression, these data suggested that NS1 was the predominant regulator of miRNA expression and subsequent experiments were focused on elucidating this role.…”
Section: Rsv Ns1 Suppresses Mir-24 Expressionsupporting
confidence: 67%
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“…RSV DNS1 and DNS2 viruses exhibited delayed growth 24 h postinfection (p.i.) due to an inability to counter the host innate immune response, as has been reported previously (Spann et al, 2005). As the opposite phenotypes occurred with NS1 deficiency versus overexpression, these data suggested that NS1 was the predominant regulator of miRNA expression and subsequent experiments were focused on elucidating this role.…”
Section: Rsv Ns1 Suppresses Mir-24 Expressionsupporting
confidence: 67%
“…Codon deoptimized RSV is attenuated in vitro, but evokes a strong humoral response upon vaccination and challenge (Meng et al, 2014). These and other immune modulators inhibit the development of the antiviral state (Bossert et al, 2003;Elliott et al, 2007;Goswami et al, 2013;Lo et al, 2005;Moore et al, 2008;Oshansky et al, 2009a;Spann et al, 2005).…”
Section: Introductionmentioning
confidence: 99%
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