Effects of noradrenaline and serotonin on activity of single lateral and medial geniculate neurons

Torda, Clara

doi:10.1016/0306-3623(78)90035-6

Cited by 12 publications

(4 citation statements)

References 60 publications

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“…Several symptoms of slow wave sleep are mediated by increased local availability of serotonin, and those of REM sleep by increased local availability of acetylcholine Jouvet & Matsunioto, 1964;MacCarley & Hobson (review), 1971 ;Torda, 1967Torda, , 1968aTorda, ,b, 1969Verzeano et al, 1975). 5-HT exerts its effects partially: (a) through inhibition of both the release fiom presynaptic storage vesicles and the effectiveness at the receptors of acetylcholine (Torda, 1978a(Torda, ,b, 1979c and (b) changes of membrane excitability through direct or indirect (Woolley & Gommi, 1963) modification of the Ca-gating mechanism (Torda, 1978b(Torda, ,c,d, 1979a.…”

Section: Jalfrementioning

confidence: 99%

A Code for Ponto-Geniculo-Occipital Wave (PGO)

Torda¹

1980

International Journal of Neuroscience

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Section: Jalfrementioning

confidence: 99%

A Code for Ponto-Geniculo-Occipital Wave (PGO)

Torda¹

1980

International Journal of Neuroscience

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“…Early workers (Curtis and Davis, 1962;Phillis et al, 1967) described an inhibitory effect of microelectrophoretically applied norepinephrine on single neurons in the lateral geniculate nucleus; later authors, however, reported a dual effect (i.e., excitation and depression) in this structure (Satinsky, 1967;Tebecis and DiMaria, 1972;Torda, 1978). More recently, Aghajanian and colleagues described an almost exclusively excitatory effect of norepinephrine on single neurons in the lateral geniculate nucleus Aghajanian, 1980a,b,c, 1982;Menkes et al, , 1983bMarwaha and Aghajanian, 1982a,b;Aghajanian and Rogawski, 1983).…”

Section: Lateral Geniculate Nucleusmentioning

confidence: 99%

The alpha-1 Adrenergic Receptors

Ruffolo¹

1987

The Receptors

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All rights reservedNo part of this book may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, microfilming, recording, or otherwise without written permission from the Publisher.Preface vii ology will allow alpha-l adrenergic receptors to be isolated and purified and their amino acid sequence to be identified. This will ultimately allow for the systematic subclassification of alpha-l adrenergic receptors and for their differential regulation to be studied in greater detail. These new advances are likely to take place within the next five years, and it is our intent for this review of alpha-l adrenergic receptor pharmacology to provide an accurate summary of the current state of knowledge relating to alpha-l adrenergic receptors, which we hope will serve as a foundation upon which to build a broader base of knowledge in the future.

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“…The neurotransmitters in postganglionic sympathetic nerve fibers mainly include norepinephrine (NE), epinephrine, acetylcholine (ACh), purine, and polypeptides. Noradrenergic regulation of the central auditory system occurs at several levels, including the cochlear nucleus, 7 the lateral superior olive, 8 medial geniculate nucleus, 9,10 and auditory cortex, [11][12][13][14] where NE alters intrinsic and synaptic physiology. NE exerts a modulatory effect on neuronal activities through the activation of α 2 -adrenergic receptors (ARs).…”

Section: Introductionmentioning

confidence: 99%

Expression and localization of α<sub>2A</sub>-adrenergic receptor in the rat post-natal developing cochlea

Tian,

Yang,

et al. 2023

Eur J Histochem

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Lots of adrenergic receptors (ARs) are widely present across the auditory pathways and are positioned to affect auditory and vestibular functions. However, noradrenergic regulation in the cochlea has not been well characterized. In this study, a rat model of noise-induced hearing loss was developed to investigate the expression of α2A-adrenergic receptor (AR) after acoustic trauma, then, we investigated the expression of α2A-AR in the developing rat cochlea using immunofluorescence, qRT-PCR, and Western blotting. We found that the expression of α2A-AR significantly increased in rats exposed to noise compared with controls. Immunofluorescence analysis demonstrated that α2A-AR is localized on hair cells (HCs), spiral ganglion neurons (SGNs), and the stria vascularis (SV) in the postnatal developing cochlea from post-natal day (P) 0 to P28. Furthermore, we observed α2A-AR mRNA reached a maximum level at P14 and P28 when compared with P0, while no significant differences in α2A-AR protein levels at the various stages when compared with P0. This study provides direct evidence for the expression of α2A-AR in HCs, SGNs, and the SV of the cochlea, indicating that norepinephrine might play a vital role in hearing function within the cochlea through α2A-AR.

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Effects of noradrenaline and serotonin on activity of single lateral and medial geniculate neurons

Cited by 12 publications

References 60 publications

A Code for Ponto-Geniculo-Occipital Wave (PGO)

A Code for Ponto-Geniculo-Occipital Wave (PGO)

The alpha-1 Adrenergic Receptors

Expression and localization of α<sub>2A</sub>-adrenergic receptor in the rat post-natal developing cochlea

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Effects of noradrenaline and serotonin on activity of single lateral and medial geniculate neurons

Cited by 12 publications

References 60 publications

A Code for Ponto-Geniculo-Occipital Wave (PGO)

A Code for Ponto-Geniculo-Occipital Wave (PGO)

The alpha-1 Adrenergic Receptors

Expression and localization of &#945;<sub>2A</sub>-adrenergic receptor in the rat post-natal developing cochlea

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Product

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Expression and localization of α<sub>2A</sub>-adrenergic receptor in the rat post-natal developing cochlea