Effects of noradrenergic activity on temporal information processing in humans

Rammsayer, Thomas; Hennig, Jürgen; Haag, Anja; Lange, Natalie

doi:10.1080/02724990143000036

Cited by 66 publications

(49 citation statements)

References 70 publications

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“…Moreover, the involvement of the IPL is in line with the idea that suprasecond time estimation is mediated by attention and working memory (Lewis & Miall, 2006). In pharmacological studies, it has been shown that benzodiazepines and remoxipride that influence working memory impair suprasecond time perception without affecting subsecond timing (Rammsayer, Hennig, Haag, & Lange, 2001;Rammsayer, 1994Rammsayer, , 1997Rammsayer, , 1999Rammsayer & Vogel, 1992). Similar dissociation was also shown by the administration of selective noradrenaline reuptake inhibitor reboxetene (Rammsayer et al, 2001).…”

Section: Suprasecond Timing and Parietal Regionsupporting

confidence: 56%

Dissociable Neuroanatomical Correlates of Subsecond and Suprasecond Time Perception

Hayashi

Kantele

Walsh

et al. 2014

Journal of Cognitive Neuroscience

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Abstract■ The ability to estimate durations varies across individuals.Although previous studies have reported that individual differences in perceptual skills and cognitive capacities are reflected in brain structures, it remains unknown whether timing abilities are also reflected in the brain anatomy. Here, we show that individual differences in the ability to estimate subsecond and suprasecond durations correlate withg r a ym a t t e r( G M )v o l u m ei n different parts of cortical and subcortical areas. Better ability to discriminate subsecond durations was associated with a larger GM volume in the bilateral anterior cerebellum, whereas better performance in estimating the suprasecond range was associated with a smaller GM volume in the inferior parietal lobule. These results indicate that regional GM volume is predictive of an individualʼs timing abilities. These morphological results support the notion that subsecond durations are processed in the motor system, whereas suprasecond durations are processed in the parietal cortex by utilizing the capacity of attention and working memory to keep track of time. ■

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Section: Suprasecond Timing and Parietal Regionsupporting

confidence: 56%

Dissociable Neuroanatomical Correlates of Subsecond and Suprasecond Time Perception

Hayashi

Kantele

Walsh

et al. 2014

Journal of Cognitive Neuroscience

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“…The relative insensitivity of short interval timing to the disruptive effects of drugs has been taken as evidence against a unitary account of timing based on a single timer. Instead, it is suggested that drugs affect longer-interval timing by impacting on selective attentional process; since durations up to around 300 ms are not affected by manipulations that alter selective attention, shorter intervals (perhaps more dependent on sensory-motor, rather than attentional processes) are likely to be more resistant to the effects of drugs that impair selective attention (e.g., Mattes and Ulrich 1998;Rammsayer et al 2001). Such an account would be consistent with the present findings.…”

Section: Discussionsupporting

confidence: 82%

“…Many drug effects on timing are specific to certain time intervals: for example, the minor tranquillizer midazolam, the atypical neuroleptic remoxipride, and the NMDA receptor antagonist memantine, all reduce estimation accuracy for longer time intervals (in the range of seconds) but not for shorter intervals (in the range of hundreds of milliseconds; Rammsayer 1992Rammsayer , 1993Rammsayer , 1997Rammsayer , 1999Rammsayer , 2006, and the noradrenaline reuptake inhibitor reboxetine improves accuracy only at longer intervals (Rammsayer et al 2001). These dissociations, together with recent neuroimaging evidence (for a review see Lewis and Miall 2003) suggest that intervals below and above approximately one second are represented by two distinct timing processes that may be differentially sensitive to drug effects.…”

Section: Introductionmentioning

confidence: 99%

Dissociations between motor timing, motor coordination, and time perception after the administration of alcohol or caffeine

et al. 2008

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Rationale The impacts of psychoactive drugs on timing have usefully informed theories of timing and its substrates. Objectives The objectives of the study are to test the effects of alcohol and caffeine on the explicit timing involved in tapping with the implicit timing observed in the coordinated picking up of an object, and with the temporal discrimination. Materials and methods Participants in the "alcohol" experiment (N=16) received placebo, "low" (0.12 g/kg or 0.14 g/kg for women/men, respectively) or "high" (0.37 g/kg or 0.42 g/kg, respectively) doses of alcohol, and those in the "caffeine" experiment (N=16) received placebo, 200 or 400 mg caffeine. Time production variability was measured by repetitive tapping of specified intervals, and sources of variance attributable to central timer processes and peripheral motor implementation were dissociated. The explicit timing in tapping was compared with the implicit timing in the coordinated picking up of an object. Time perception was measured as discrimination thresholds for intervals of similar duration. Drug effects on reaction time were also measured. Results For tapping, alcohol significantly increased timer variability, but not motor variability; it did not affect coordination timing in the grip-lift task. Conversely, for time perception, the low dose of alcohol improved temporal discrimination. Caffeine produced no effects on any of the timing tasks, despite significantly reducing reaction times. Conclusions The effects of alcohol argue against a common clock process underlying time interval perception and production in the range below 1 s. In contrast to reaction time measures, time perception and time production appear relatively insensitive to caffeine.

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“…Antidepressants and septo-hippocampal oscillation M Hajó s et al disturbances associated with depression (Kasper et al, 2000;Rammsayer et al, 2001;Ferguson et al, 2002). Even though both NE and serotonin reuptake inhibitors are shown to be clinically effective antidepressant drugs, their acute action on the septo-hippocampal oscillatory behavior is different.…”

Section: Controlmentioning

confidence: 99%

Norepinephrine but not Serotonin Reuptake Inhibitors Enhance Theta and Gamma Activity of the Septo-Hippocampal System

Hajós¹,

Hoffmann²,

Robinson³

et al. 2002

Neuropsychopharmacol

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Current neurobiological concepts attribute a central role of the hippocampal formation in cognitive and affective processes. Recent studies indicate that the hippocampus is affected in human depression, and antidepressant drugs induce hippocampal adaptive changes that are thought to be associated with their therapeutic action. In the present study, we investigated the action of various antidepressant drugs on the activity of the septo-hippocampal system, its oscillatory activity in particular. The acute effects of the norepinephrine (NE) reuptake inhibitors reboxetine and desipramine, and the selective serotonin reuptake inhibitor fluvoxamine were evaluated. Extracellular single-unit recordings were performed from the medial septum/diagonal band of Broca (MS/DBv), with simultaneous hippocampal EEG recordings of anesthetized rats. Systemic administration of reboxetine synchronized hippocampal EEG, resulting in a significant increase in power at theta frequency, and an increase in frequency and power of gamma-wave activity. Parallel to EEG synchrony, reboxetine induced or enhanced theta oscillation of MS/DBv neurons. Oscillatory frequencies of MS/DBv neurons were identical, and phase locked to the corresponding hippocamapal theta frequencies. Under the same experimental conditions, reboxetine induced a two-fold increase in extracellular NE (but not serotonin) levels in the hippocampus as revealed by microdialysis. Desipramine, but not the serotonin reuptake inhibitor fluvoxamine, evoked responses similar to those of reboxetine regarding septo-hippocampal theta activity. The present findings indicate that even though both NE and serotonin reuptake inhibitors are clinically effective antidepressant drugs, their action on the septo-hippocampal oscillatory behavior is different. It is presumed that selective NE reuptake inhibitors could modulate various cognitive processes associated with hippocampal oscillatory activity.

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Effects of noradrenergic activity on temporal information processing in humans

Cited by 66 publications

References 70 publications

Dissociable Neuroanatomical Correlates of Subsecond and Suprasecond Time Perception

Dissociable Neuroanatomical Correlates of Subsecond and Suprasecond Time Perception

Dissociations between motor timing, motor coordination, and time perception after the administration of alcohol or caffeine

Norepinephrine but not Serotonin Reuptake Inhibitors Enhance Theta and Gamma Activity of the Septo-Hippocampal System

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