Effects of noradrenergic and serotonergic systems on risk-based decision-making and center arena activity in open field in rats

Cui, Ruisi; Wang, Lutong; Liu, Liyuan; Ruan, Heng; Li, Xinwang

doi:10.1016/j.ejphar.2018.09.026

Cited by 11 publications

(5 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Allied to this memory deficit, female mice exposed to ZIKV exhibited risk-taking behavior, as they spent a greater percentage of time in the center of the open field apparatus, while male mice did not show such behavioral alteration in comparison to their control group. These results differ from what has been published previously, showing that ZIKV infection leads either to no change or to anxious behavior, as ZIKV-infected animals spend less time in the center of the open field apparatus ( Cui et al, 2018 ; De Sousa et al, 2020 ). However, a recently published study indicates that ZIKV-infected animals (P1) spend more time on the open arm of the elevated plus maze, which is indicative of risk-taking behavior ( Ireland et al, 2020 ).…”

Section: Discussioncontrasting

confidence: 99%

“…Regarding the Y-maze test, MOCK and ZIKV-exposed male and female mice exhibited preserved working memory, as the index of correct spontaneous alternation exhibited by these experimental groups was higher than chance (50%) ( Figure 1 C, 1E). The open field test evaluates spontaneous locomotor activity, as well as anxiety/risk-taking behavior by assessing the percentage of time animals spend in the center of the apparatus ( Stanford, 2007 ; Cui et al, 2018 ). There was no difference in the total distance traveled when comparing MOCK- and ZIKV-exposed female ( Figure 1 F, 1G) and male ( Figure 1 H, 1I) mice.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

In UteroExposure to Zika Virus Results in sex-Specific Memory Deficits and Neurological Alterations in Adult Mice

et al. 2022

View full text Add to dashboard Cite

Transplacental transmission of Zika virus (ZIKV) during early pregnancy may lead to several neurological alterations, known as congenital Zika syndrome. We have previously shown that intravaginal infection of immunocompetent dams with ZIKV during the early stage of pregnancy triggers neuroinflammation in fetuses, characterized by increased brain expression of inflammatory factors, including IL-6, IL-18, CCL2, CXCL1, and CXCL10. The present study sought to understand the long-term consequences of these early cerebral alterations. For that, pregnant FVB/NJ immunocompetent females were infected intravaginally on the gestational day (GD) 4.5 and experiments were performed when offspring reached between 4 to 5 months of age. The exposure to ZIKV promoted significant neuronal cell loss detected in the CA1 region of the hippocampus of adult mice. However, only females showed reduced expression levels of brain-derived neurotrophic factor (BDNF), postsynaptic density protein 95 (PSD95), and syntaxin-1A, which are important genes related to neuronal function and synaptic plasticity. Moreover, the protein levels of the pre- and postsynaptic markers, SNAP25 and PSD95, respectively, were decreased exclusively in ZIKV-exposed female mice, indicating that ZIKV exposure in utero induces synaptic loss. Additionally, only females exposed to ZIKV showed risk-taking behavior and hippocampal-dependent spatial memory deficit. Together, these results demonstrate that intravaginal infection of mice on GD4.5 induces neurological alterations in the offspring detectable in their adulthood and that female mice, rather than male mice, are more susceptible to ZIKV-induced neurobehavioral alterations. Summary Statement In utero exposure to ZIKV leads to decreased number of neurons in adult mice. Female mice exposed to ZIKV in utero exhibit lower levels of BDNF, a decrease in synaptic markers, memory deficits, and risk-taking behavior during adulthood.

show abstract

Section: Discussioncontrasting

confidence: 99%

Section: Resultsmentioning

confidence: 99%

In UteroExposure to Zika Virus Results in sex-Specific Memory Deficits and Neurological Alterations in Adult Mice

et al. 2022

View full text Add to dashboard Cite

show abstract

“…[20] Also, another study showed that duloxetine (5 mg/kg) increased center arena activity in OFT. [21] In this study, 5, 10 and 30 mg/kg duloxetine injection significantly increased locomotor activity, but 1 mg/kg duloxetine did not alter the number of squares crossed.…”

Section: Discussionmentioning

confidence: 45%

The effect of duloxetine on ECoG activity of absence-epilepsy model in WAG/Rij rats

Aygün

2019

Journal of Contemporary Medicine

View full text Add to dashboard Cite

Introduction: Many epidemiological studies have found a high incidence of depression and anxiety in people with epilepsy. Duloxetine is a selective inhibitor of serotonin and norepinephrine reuptake (SNRI) and commonly prescribed in a patient with major depressive disorder. The aim of this study was to investigate the effect of duloxetine on the WAG/Rij rat in an experimental rat model of absence-epilepsy. Methods: WAG/Rij rats were randomly assigned into 5 groups with 7 animals in each group. Tripolar electrodes were placed on the skull to perform electrocorticography (ECoG) evaluation. Then, following the recovery period, ECoGs were recorded at 09:00 am for 3 hours every day. Subsequently, duloxetine (1, 5, 10 and 30 mg/kg) was injected intraperitoneally (i.p). After the treatment program, ECoG recordings were taken for 3 hours. And then all animal anxiety-like behavior by using the behavioral test, open field test (OFT) was performed after duloxetine (1,5,10 and 30 mg/kg) treatment. The total number and the total duration of the spike-wave discharges (SWDs) were calculated offline. The number of squares crossed (locomotor activity) and the duration of grooming episodes were analyzed in OFT. Results: The doses of duloxetine (1 mg/kg) did not alter ECoG and OFT parameters. The 5, 10 and 30 mg/kg doses of duloxetine decreased the total number and the total duration of SWDs, (p<0.05) and increased the number of squares crossed when compared to with control group (p<0.05) without changing duration of grooming episodes (p>0.05). Intraperitoneal administering of 1 mg/kg duloxetine did not show any statistically significant change in regard to the number and duration of SWDs. Discussion and Conclusion: In the present study, duloxetine reduce dose-dependent absences-like seizures and anxiety-like behavior.

show abstract

“…While the behavior of our animals was comparable across tasks (Supplemental Fig. 4), and these tasks are commonly used in rodent operant literature (Cui et al, 2018;Mar et al, 2011;McMurray et al, 2016), they are not equipped to assess variables such as animal indifference points (Winstanley, 2011). The indifference point is the probability (or delay) at which the animal equates the value of the smaller and larger options.…”

Section: Discussionmentioning

confidence: 99%

Extent of food restriction affects probability but not delay‐based decision‐making

Tapp

Zerkle

McMurray

2020

J Exper Analysis Behavior

View full text Add to dashboard Cite

Rodent studies on decision‐making often use food rewards and food‐restrict subjects in order to motivate performance. However, food restriction has widespread effects on brain and behavior, which depend on factors including extent of restriction and feeding schedule. These factors are well recognized for their effects on motivation, but may also cause effects on decision‐making independent of motivation. We examined how the degree of weight‐based food restriction in rats influenced decision‐making on the probability and delay discounting tasks. Additionally, we examined how the method of food restriction (consistent amount vs. time constrained feeding schedule) influenced decision‐making. Our results showed that the degree of weight‐based food restriction significantly altered probability, but not delay discounting, and that these effects were not entirely explainable by differences in motivation. Additionally, the method of food restriction did not significantly influence discounting when animals were within the same range of weight‐based restriction. Together, our findings suggest that the degree of food restriction may modulate the neural circuitry responsible for selective aspects of decision‐making related to probability. Further, these data support the need for tight control and reporting of weight and feeding in studies relying on food restriction, and suggest that the effects of food restriction may be broader than previously considered.

show abstract

Effects of noradrenergic and serotonergic systems on risk-based decision-making and center arena activity in open field in rats

Cited by 11 publications

References 39 publications

In UteroExposure to Zika Virus Results in sex-Specific Memory Deficits and Neurological Alterations in Adult Mice

In UteroExposure to Zika Virus Results in sex-Specific Memory Deficits and Neurological Alterations in Adult Mice

The effect of duloxetine on ECoG activity of absence-epilepsy model in WAG/Rij rats

Extent of food restriction affects probability but not delay‐based decision‐making

Contact Info

Product

Resources

About