Effects of novel odors on intermale attack behavior in mice

Kemble, Ernest D.; Garbe, Colleen M.; Gordon, Christopher J.

doi:10.1002/1098-2337(1995)21:4<293::aid-ab2480210405>3.0.co;2-t

Cited by 11 publications

(5 citation statements)

References 18 publications

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“…The results of this experiment were generally consistent with our earlier fmdings of odor-induced hyperdefensiveness (Garbe et al, in pre ss) and decreased aggression (Kemble & Garbe, 1993) among male mice . Taken together, these data provide evidence that novel odors elevate defensiveness toward either predators or litter-threatening male conspecifics .…”

Section: Discussionsupporting

confidence: 91%

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Effects of novel odor exposure on maternal aggression in mice

Garbe

Kemble

1993

Bull. Psychon. Soc.

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A variety of novel odors increase both risk assessment and defensive behaviors and inhibit offensive attack among male mice. In this experiment, the effects of a novel mammalian (wool) and nonmammalian (chocolate) odor on maternal aggression were examined. Both novel odors produced a mild suppression of lunge attacks. In addition, the chocolate odor reduced boxing behavior and the wool odor increased grooming. Neither odor altered other social behaviors. The results are consistent with previous data insuggesting that odor novelty evokes fear-motivated defensiveness and inhibits attack. These effects appear to be somewhat weaker than those seen among male mice, however.The odors of a potential predator (cat) evoke a number of species-typical defensive behaviors in rats (e.g ., stretched attention, flatback approach) , which have been characterized as risk assessment (R.

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Section: Discussionsupporting

confidence: 91%

“…Novel odors were provided by 1.0 g of untreated sheep wool or 7.5 mI of unsweetened powdered cocoa (Hershey 's) . Both novel odors effectively elevate risk assessment behaviors (Garbe et aI., in press) and reduce intermale attack (Kemble & Garbe , 1993). Unsoiled sawdust bedding (36.0 mil served as the control odor .…”

Section: Odorous Substancesmentioning

confidence: 99%

Effects of novel odor exposure on maternal aggression in mice

Garbe

Kemble

1993

Bull. Psychon. Soc.

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“…As with digging, some amount of grooming is normal for mice and is a marker of wellbeing, but the behavioral link between stress and grooming is less clear (De Boer and Koolhaas, 2003;Guild and Dunn, 1982;Kalueff and Tuohimaa, 2005;Smolinsky et al, 2009). For instance, some reports suggest that grooming may be a self-soothing behavior that increases under stressful conditions, while others propose that it is a "rest behavior' that indicates low levels of stress (Guild and Dunn, 1982;Kemble and Bolwahnn, 1997;Kemble et al, 1995).…”

Section: Dbh Deficiency Suppresses Odorant-induced Defensive Digging ...mentioning

confidence: 99%

“…Plant-derived odorants from essential oils are novel olfactory stimuli for laboratory mice that we posited would engender similar behavioral manifestations of psychological stress as spatial novelty or innately threatening olfactory stimuli like predator-derived scents (Dielenberg and McGregor, 2001;Hebb et al, 2002;Hwa et al, 2019;Kemble and Bolwahnn, 1997;Kemble et al, 1995;Lustberg et al, 2020b). Because many plants contain toxic secondary metabolites and/or have little or no nutritional value for rodents, defensive and avoidant responses to unfamiliar plant-derived olfactory stimuli would be adaptive for rodents in the wild to discourage appetitive behavior (Garbe et al, 1993;Hansen et al, 2016;Kemble and Gordon, 1996).…”

Section: Introductionmentioning

confidence: 98%

Norepinephrine and dopamine contribute to distinct repetitive behaviors induced by novel odorant stress in male and female mice

Lustberg

Liu²,

Iannitelli³

et al. 2022

Hormones and Behavior

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“…Grooming was defined as repetitive paw movements oriented around the whiskers and face, as well as licking or scratching of the body and tail (De Boer & Koolhaas 2003, Kalueff & Tuohimaa 2005, Smolinsky AN 2009. Some reports suggest that grooming may be a self-soothing behavior that increases under stressful conditions, while others propose that it is a "rest behavior' that indicates low levels of stress (Guild & Dunn 1982, Kemble & Bolwahnn 1997, Kemble ED 1995. For experiments with D1 receptor antagonist (see below), locomotor activity was measured as distanced traveled (m) using ANY-maze software (version 6.0, Stoelting Co, Wood Dale, IL, USA).…”

Section: Behavioral Analysismentioning

confidence: 99%

Genetic disruption of dopamine β-hydroxylase dysregulates innate responses to predator odor in mice

Liu

Lustberg

McCann

2023

Preprint

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Rodents infected with the parasite Toxoplasma gondii show reduced aversion to predator odor and diminished neophobia, and infection in humans is associated with increased risk of neuropsychiatric disorders. Norepinephrine (NE) and dopamine (DA) modulate anxiety and predator odor responses, and T. gondii suppresses dopamine β-hydroxylase (Dbh) expression thereby reducing NE and increasing DA, which may contribute to the disruption of innate host behaviors. We examined the consequences of Dbh knockout (Dbh -/-) on responses to predator odor (bobcat urine) and compared them to Dbh-competent littermate controls. Over the first 10 min of predator odor exposure, controls exhibited robust defensive burying behavior, whereas Dbh -/- mice showed high levels of grooming. Defensive burying was potently suppressed in controls by drugs that reduce NE transmission, while excessive grooming in Dbh -/- mice was blocked by DA receptor antagonism. In response to a cotton square scented with a novel neutral odor (lavender), most control mice shredded the material, built a nest, and fell asleep within 90 min. Dbh -/- mice failed to shred the lavender-scented nestlet, but still fell asleep. In contrast, controls sustained high levels of arousal throughout the predator odor test and did not build nests, while Dbh -/- mice were asleep by the 90-min time point, often in shredded bobcat urine-soaked nesting material. Compared with controls exposed to predator odor, Dbh -/- mice demonstrated decreased c-fos induction in the anterior cingulate cortex (ACC), lateral septum (LS), periaqueductal gray (PAG), and bed nucleus of the stria terminalis, but increased c-fos in the LC and medial amygdala. These data indicate that relative ratios of central NE and DA signaling coordinate the type and valence of responses to predator odor, and suggest that Dbh -/- mice may represent a useful monogenetic model of neurobiological changes conferred by T. gondii infection.

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Effects of novel odors on intermale attack behavior in mice

Cited by 11 publications

References 18 publications

Effects of novel odor exposure on maternal aggression in mice

Effects of novel odor exposure on maternal aggression in mice

Norepinephrine and dopamine contribute to distinct repetitive behaviors induced by novel odorant stress in male and female mice

Genetic disruption of dopamine β-hydroxylase dysregulates innate responses to predator odor in mice

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