Effects of NSAIDs and hydroxyapatite coating on osseointegration

Abstract

Purpose: The aim of our study is to investigate the bone ongrowth of two different alternative surfaces and the effect of nonsteroidal anti-inflammatory drugs (NSAIDs) on osseointegration. Methods: Hips of 40 New Zealand white rabbits were operated bilaterally. Hydroxyapatite (HA)-coated titanium rods were implanted into the right femur, and gritblasted titanium rods were implanted into the left femur. They were divided into three groups. At the end of 8 weeks, both femora of the rabbits were removed and investigated biomechanically and histologically. Results: HA-coated implants had a significantly better failure load and ''percentage of bone-implant contact'' than grit-blasted implants. There was no significant difference between the medication groups as a result of the biomechanical and histologic investigations. Conclusions: Our results indicate that NSAIDs did not have any negative effect on the osseointegration. HA-coated implants may provide more tensile strength and greater bone-implant contact rate in comparison with gritblasted implants.

The effects of a nonsteroidal anti-inflammatory drug on the degree of titanium implant osseointegration

“…30 They demonstrated that the administration of appropriate doses of DCS and parecoxib did not negatively affect osseointegration and bone healing in either the short or long term. In a recent study conducted by Salduz et al, 31 the effects of an eight-week postoperative course of 5 mg/kg/ day of DCS and 3 mg/kg/day of celecoxib on osseointegration were investigated. The NSAIDs were not found to have a negative effect on either the extent of the BIC or osseointegration.…”

The effect of non-steroidal anti-inflammatory drugs on the osteogenic activity in osseointegration: a systematic review

“… Control ( n = 14) Meloxicam ( n = 16) Daily subcutaneous injections for 60 days: control, 1 mL/kg of saline Meloxicam, 3 mg/kg Histomorphometric analysis at 60 days after implant insertion: bone-to-implant contact, bone area, and bone density in the cortical and cancellous bone areas Blasting implant surface with aluminium oxide can increase bone-to-implant contact; however, it does not reverse the negative effects caused by a selective COX-2 inhibitor on bone healing around implants. Salduz et al (2017) [ 32 ] New Zealand white rabbits, skeletally mature weighing 3.5–4 kg ( n = 40). Titanium rods implanted bilaterally in femur ( n = 80).…”

“…Their results revealed no statistically significant differences between the experimental groups and the control [ 22 ]. Furthermore, a recent study conducted by Salduz et al that investigated the effect of a non-selective COX inhibitor (diclofenac, 5 mg/kg/day) and a selective COX-2 inhibitor (celecoxib, 3 mg/kg/day) administered for 8 weeks on bone growth and osseointegration on two different alternative titanium surfaces revealed no statistically significant differences in the biomechanical and histological results between the experimental groups and the control, suggesting that long-term use of NSAIDs does not affect osseointegration [ 32 ]. The data collected in animal studies regarding duration of treatment and drug selectivity is inconsistent, and there is a lack of consensus on the influence of NSAIDs on osseointegration in animal models.…”

Biochemical and histopathological effects of diclofenac and ketoprofen administration on bone regeneration

“…Studies have evaluated the effect of NSAIDs on fracture healing by causing deterioration of osteoblast proliferation in the initial stages of the regeneration process; nonetheless, there are no conclusive results because there is a lot of heterogeneity in the designs, doses, treatment periods and use of different experimental animals [12][13][14].…”