Objective: Hypertension and dyslipidemia are widely recognized a major risk factors for cardiovascular disease (CVD). The aim of this study was to evaluate the effectiveness of the nursing intervention on cholesterol level and quality of life (QOL) among hypertensive patients with dyslipidemia. Methods: Design: A quasi -experimental pre-post-test design was used to achieve the aim of the study. The study was conducted in the University Hospital at Shebin El-kom District, Menoufia Governorate, Egypt. Purposeful sample of 100 hypertensive patients with dyslipidemia on treatment from the previous mentioned setting. Instruments: (1) structured interview questionnaire to assess socio-demographic data, risk factors of hypertension and dyslipidemia and patient's knowledge about hypertension and dyslipidemia; (2) Physiological measurement to assess blood pressure, weight and cholesterol level; (3) QOL scale to assess healthful lifestyle. Results: The main findings of the study there was statistically significant improvement of total knowledge related to hypertension and dyslipidemia, and there was statistically significant reduction in blood pressure and cholesterol level post-intervention than pre-intervention. Conclusions: The nursing intervention has a positive effect on blood pressure, cholesterol level and QOL of hypertensive patients with dyslipidemia. Recommendations: The nursing intervention that includes of adherence to diet regimen, prescribed medication and performing physical exercise, stress management, assertiveness training should be integrated into medical outpatient clinic to assist patients diagnosed with hypertension to cope with their illness and improve the QOL of hypertensive patients.