Effects of nutritional education and lifestyle modification on the nutritional status of HIV positive patients: results of a cluster randomized intervention over a period of six months

Nkengfack, Germaine; Torimiro, Judith; Ngogang, Jeanne; Englert, Heike

doi:10.7243/2052-5966-1-5

Cited by 4 publications

(23 citation statements)

References 31 publications

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“…We identified 12 unique studies (Figure 1) that examined the influence of nutrition education and counselling on the occurrence of important clinical outcomes among PLHIV. These studies were either RCTs [28][29][30], cluster RCTs [7,31], pre-post interventional studies [22,31,32] or pre-post interventional studies based on one arm of an RCT [33][34][35]. All studies were conducted among adults.…”

Section: Summary Of Included Studiesmentioning

confidence: 99%

“…In one study, a caregiver was required to be present. Most studies did not specify who delivered the intervention [7,22,28,31,[34][35][36]. In one study, nutrition counselling was delivered by a peer [31].…”

Section: Counselling/education Interventionsmentioning

confidence: 99%

“…Most studies did not specify who delivered the intervention [7,22,28,31,[34][35][36]. In one study, nutrition counselling was delivered by a peer [31]. At other times, a dietician or nutritionist delivered the intervention [29,30].…”

Section: Counselling/education Interventionsmentioning

confidence: 99%

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Nutrition counselling and clinical outcomes in HIV: A systematic review and meta‐analysis

Okusanya,

Okoka,

Kuyebi

et al. 2023

HIV Medicine

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BackgroundPeople living with the HIV (PLHIV) are at an increased risk of various diseases due to a weakened immune system, particularly if they are naïve or poorly adherent to antiretroviral therapy (ART). Nutrients play a critical role in improving immune health, especially among this population. We systematically reviewed the evidence concerning the impact of nutritional counselling on the occurrence of important clinical outcomes among PLHIV.MethodsMedical literature databases (PubMed, EMBASE and Web of Science) were searched from inception to October 2022 for relevant published studies (n = 12) of nutritional counselling and HIV‐related outcomes in adults on ART. Random‐effects meta‐analyses were conducted when the exposure–outcome relationships were similar in three or more studies.ResultsAlthough the methodologies of nutritional intervention varied across all studies, overall, the evidence from the meta‐analysis indicates a nsignificant positive association between nutrition counselling and improvements in CD4 cell count, body mass index and low‐density lipoprotein concentration. However, the existing literature does not provide enough evidence to establish a significant impact of nutrition counselling on other immune, anthropometric, and metabolic outcomes including viral load, weight, and lean mass due to the differences in the study designs.ConclusionWell‐powered randomized controlled trials are needed that explore the effect of evidence‐based, individualized nutrition counselling on HIV‐related clinical outcomes.

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Section: Summary Of Included Studiesmentioning

confidence: 99%

Section: Counselling/education Interventionsmentioning

confidence: 99%

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Nutrition counselling and clinical outcomes in HIV: A systematic review and meta‐analysis

Okusanya,

Okoka,

Kuyebi

et al. 2023

HIV Medicine

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“…Several studies have demonstrated spirulina's beneficial effects and therapeutic functions [ 22 23 ]. Other studies have shown that spirulina has beneficial effects on the treatment of malnutrition and other pathologies such as obesity, hypercholesterolemia, hypertension, and diabetes mellitus [ 24 25 26 ]. Studies have reported spirulina was associated with modulation of the host immune system.…”

Section: Introductionmentioning

confidence: 99%

Monocyte chemoattractant protein-1 polymorphism interaction with spirulina immunomodulatory effects in healthy Korean elderly: A 16 week, double-blind randomized clinical trial

Park

Lee

2017

Nutr Res Pract

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BACKGROUND/OBJECTIVESSpirulina is a known a functional food related to lipid profiles, immune functions, and antioxidant capacity. Circulating monocyte chemoattractant protein-1 (MCP-1) level is associated with inflammation markers. Single nucleotide polymorphism in the MCP-1 promoter region -2518 have been identified and shown to affect gene transcription. Gene variation may also impact functional food supplementary effects. The current study investigated the interaction of MCP-1 -2518 polymorphism with spirulina supplements on anti-inflammatory capacity in Korean elderly.SUBJECTS/METHODSAfter genotyping, healthy elderly subjects (n = 78) were included in a randomized, double blind, and placebo controlled study. Baseline characteristic, body composition, and dietary intake were measured twice (baseline vs. week 16). For 16 weeks, subjects consumed 8 g either spirulina or placebo daily. Plasma MCP-1, interleukin (IL) -2, IL-6, tumor necrosis factor (TNF)-α, complement (C) 3, immunoglobulin (Ig) G, and Ig A concentrations and lymphocyte proliferation rate (LPR) were analyzed as inflammatory markers.RESULTSIn the placebo group with A/A genotype, MCP-1 level was significantly increased, but the spirulina group with A/A genotype was unchanged. IL-2 was significantly increased only in subjects with spirulina supplementation. TNF-α was significantly reduced in subjects with the G carrier. C3 was significantly increased in the placebo group, particularly when A/A increased more than G, but not when spirulina was ingested. LPR was significantly different only in subjects with A/A genotype; there was a significant increase in phytohemagglutinin and lipopolysaccharide induced LPR in the spirulina group.CONCLUSIONIn healthy Korean elderly, spirulina supplementation may influence different inflammatory markers by the MCP-1 genotype. These results may be useful for customized dietary guidelines to improve immune function in Koreans.

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“…Several studies demonstrated beneficial effects of S. platensis in vitro and in vivo as well as its therapeutic functions [ 13 , 14 ]. In addition, some studies show that spirulina has beneficial effects on the treatment of malnutrition and on other pathologies such as obesity, hypercholesterolaemia, arterial hypertension and diabetes mellitus [ 15 – 17 ]. This study was performed, to assess the potential effects of 10 grams of daily supplementation of S. platensis with a local balance diet on the level of CD4 cells count and viral load during six months by treatment naïve HIV–infected persons.…”

Section: Introductionmentioning

confidence: 99%

Impact of daily supplementation of Spirulina platensis on the immune system of naïve HIV-1 patients in Cameroon: a 12-months single blind, randomized, multicenter trial

Ngo-Matip

Pieme

Azabji-Kenfack

et al. 2015

Nutr J

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BackgroundMicronutrient deficiencies occur early in Human Immunodeficiency Virus (HIV) infections they have reverse effects on the nutritional status. The diet supplementation with a natural nutraceutical rich in proteins and micronutrient like Spirulina platensis, may be effective and efficient in delaying HIV disease progression by frequently reported improvement in immune response.MethodsA prospective single-blind, randomized, multicenter study conducted on 320 HIV-1 ARV-naïve participants for 12 months. Participants received either S. platensis supplementation and standard care or standard care and local balanced diet without S. platenis. Selected hematological and biochemical as well as CD4 count cells, viral load copies were assessed at three separate times.ResultsAmong the 169 ART-naïve participants enrolled in the study, the female was mostly represented (67.1 %). The significant increase of CD4 count cells (596.32–614.92 cells count) and significant decrease of viral load levels (74.7 × 103–30.87 × 103 copies/mL) of the patients who received a supplementation of S. platensis was found after 6 months of treatment. Haemoglobin level was also significantly higher in the same group while the fasting blood glucose concentration decreased after 12 months compared to control.ConclusionA daily supplementation with S. platensis to diet combined with a reasonable balanced diet has significantly increased the CD4 cells and reduced the viral load after 6 months. Further studies are recommended among a large specific group of people infected by the HIV in order to investigate the mechanisms involved on the effect of S. platensis on immune system.

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Effects of nutritional education and lifestyle modification on the nutritional status of HIV positive patients: results of a cluster randomized intervention over a period of six months

Cited by 4 publications

References 31 publications

Nutrition counselling and clinical outcomes in HIV: A systematic review and meta‐analysis

Nutrition counselling and clinical outcomes in HIV: A systematic review and meta‐analysis

Monocyte chemoattractant protein-1 polymorphism interaction with spirulina immunomodulatory effects in healthy Korean elderly: A 16 week, double-blind randomized clinical trial

Impact of daily supplementation of Spirulina platensis on the immune system of naïve HIV-1 patients in Cameroon: a 12-months single blind, randomized, multicenter trial

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