Effects of obesity on QT, RR, and QTc intervals

El-Gamal, Alaa Eldin M.; Gallagher, Dympna; Nawras, Ali; Gandhi, Pragnesh; Gomez, Jorge; Allison, David B.; Steinberg, Jonathan S.; Shumacher, Donald; Blank, Roy; Heymsfield, Steven B.

doi:10.1016/s0002-9149(99)80700-0

Cited by 108 publications

(83 citation statements)

References 21 publications

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“…12,16 Frank et al 12 found a low but statistically signi®cant relationship (r 0.22, P`0.001) between percent overweight and QTc interval in obese patients without cardioactive medications. In addition, El-Gamal et al 15 recently found signi®cant correlations between QTc intervals and both BMI (r 0.31, P 0.0002) and %BF (r 0.25, P 0.003) in healthy obese people. In contrast to these studies, Peiris et al 16 reported no association between obesity and QTc interval in healthy premenopausal women.…”

Section: Discussionmentioning

confidence: 93%

“…9,14 The length of the QTc interval was found to be exponentially related to the risk of developing MVA in patients with QT prolongation. In healthy obese subjects, El-Gamal et al 15 reported that prolongation of the QTc interval was signi®cantly associated with relative body mass and fatness, whereas Peiris et al, 16 found no signi®cant association.…”

Section: Introductionmentioning

confidence: 99%

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Effect of obesity and regional adiposity on the QTc interval in women

Park

Swan

1997

Int J Obes

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OBJECTIVES: To determine whether differences in body fat composition and body fat distribution patterns are associated with a prolongation of the corrected QT interval for heart rate (QTc) on the electrocardiogram (EKG) during rest and exercise. DESIGN: Cross-sectional evaluation of the QTc interval in three groups of premenopausal women during rest and two exercise conditions (50% VO 2 max and VO 2 max). SUBJECTS: Thirty-one healthy women with a mean age of 35 y (27±44 y) were classi®ed as either obese (n 22; percent body fat [%BF] b 30%) or nonobese (NO; n 9; %BF 27%) by hydrostatic weighing. Obese subjects matched for age and %BF were grouped by waist to hip ratio (WHR) into two groups: upper body obesity (UBO; n 11; WHR ! 0.85) and lower body obesity (LBO; n 11; WHR 0.75). MEASUREMENTS: RR and QT intervals were measured in a double-blind design with the aid of calipers and magnifying lens for seven consecutive beats in lead II from a 12-lead EKG at a paper speed of 25 mm/sec. Five consecutive cardiac cycles excluding the longest and shortest RR and QT intervals were averaged and calculated for QTc interval using Bazett's formula. RESULTS: Mean QTc intervals were signi®cantly different (P`0.001) across the groups for each condition. For all conditions, UBO had the longest QTc interval as compared to LBO and NO respectively (i.e., Rest: 0.426; 0.413; 0.399 sec 1/2 ; Mid50%: 0.447; 0.426; 0.409 sec 1/2 ; Max: 0.390; 0.374; 0.357 sec 1/2 ). CONCLUSIONS: The QTc interval is positively associated with UBO even at the same level of body fat in moderately obese women. It is clear that abdominal obesity may be one of the risk factors for a prolonged QTc interval in premenopausal women.

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Section: Discussionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Effect of obesity and regional adiposity on the QTc interval in women

Park

Swan

1997

Int J Obes

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“…Risk factors, such as sex, 30,63,64 body mass index, 65,66 myocardial ischemia, 67,68 heart failure, 69,70 hypothermia, 71 and hypokalemia, 72,73 have been correlated with prolonged QT intervals in other studies.…”

Section: Risk Factors and Alqtsmentioning

confidence: 94%

Acquired Long QT Syndrome: Frequency, Onset, and Risk Factors in Intensive Care Patients

Kozik

Wung

2012

Critical Care Nurse

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Background Acquired long QT syndrome is a reversible condition that can lead to torsades de pointes and sudden cardiac death. Objective To determine the frequency, onset, frequency of medications, and risk factors for the syndrome in intensive care patients. Methods In a retrospective chart review of 88 subjects, hourly corrected QT intervals calculated by using the Bazett formula were collected. Acquired long QT syndrome was defined as a corrected QT of 500 milliseconds or longer or an increase in corrected QT of 60 milliseconds or greater from baseline level. Risk factors and medications administered were collected from patients’ medical records. Results The syndrome occurred in 46 patients (52%); mean time of onset was 7.4 hours (SD, 9.4) from time of admission. Among the 88 patients, 52 (59%) received a known QTc-prolonging medication. Among the 46 with the syndrome, 23 (50%) received a known QT-prolonging medication. No other risk factor studied was significantly predictive of the syndrome. Conclusions Acquired long QT syndrome occurs in patients not treated with a known QT-prolonging medication, indicating the importance of frequent QT monitoring of all intensive care patients.

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“…8 Increase in the QT interval has been reported in obese subjects in various studies. [9][10][11][12] However, the results of these studies are controversial.…”

Section: Introductionmentioning

confidence: 99%

Effect of obesity on P-wave dispersion and QT dispersion in women

et al. 2006

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Objective: The aim of this study was to investigate the effect of obesity on dispersion of P-wave duration and QTc interval in obese women. Methods: Forty-two obese women (Body mass index (BMI) ¼ 4073 kg/m 2 , mean age 4579 years) and compared agematched (BMI ¼ 2271 kg/m 2 , mean age 4176 years) twenty-five non-obese women were included in our study. Maximum and minimum P-wave duration, P-wave dispersion (difference between the maximum and the minimum P-wave duration), maximum and minimum QTc interval, and QTc dispersion (the difference between the maximum and the minimum QTc interval) were measured from 12-lead ECG. ECG's were transferred to a personal computer via a scanner and then used for magnification of 400 times by Adobe Photoshop software. Results: There was significant difference in BMI (4073 vs 2271 kg/m 2 , Po0.001, respectively) between obese and non-obese women. Obese women had higher Max. P-wave duration (116711 vs 94714 ms, Po0.001), P-wave dispersion (51715 vs 26711 ms, Po0.001), Max. QTc interval (449738 vs 419730 ms, Po0.001) and QTc dispersion (57723 vs 38715 ms, Po0.001) compared to non-obese women. A significant correlation was found between BMI and Max. P-wave duration (r ¼ 0.584, Po0.001), P-wave dispersion (r ¼ 0.621, Po0.001), Max. QTc interval (r ¼ 0.410, Po0.001), and QTc dispersion (r ¼ 0.429, Po0.001). In the linear regression analysis, compared to co-morbidity factors such as age, hypertension, diabetes mellitus and smoking, there was significant association between only BMI and electrocardiographic values (P-wave and QTc dispersion). Conclusion: We concluded that obesity caused significant increase in P-wave and QTc dispersion. Therefore, obese women may not only be under the risk of ventricular arrhythmias, but also they may under the risk of atrial arrhythmias.

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Effects of obesity on QT, RR, and QTc intervals

Cited by 108 publications

References 21 publications

Effect of obesity and regional adiposity on the QTc interval in women

Effect of obesity and regional adiposity on the QTc interval in women

Acquired Long QT Syndrome: Frequency, Onset, and Risk Factors in Intensive Care Patients

Effect of obesity on P-wave dispersion and QT dispersion in women

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