Effects of obstructive sleep apnea on cognitive function: A comparison between younger and older OSAS patients

Mathieu, Annie; Mazza, Stéphanie; Décary, Anne; Massicotte-Marquez, Jessica; Petit, Dominique; Gosselin, Nadia; Malo, Julie; Montplaisir, Jacques

doi:10.1016/j.sleep.2007.03.014

Cited by 101 publications

(74 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Obstructive sleep apnea (OSA), a very common breathing and sleep disorder, is associated with intermittent hypoxia (IH) resulting from upper airway obstruction of structural or neural causes [1,2] . The most distinct features of OSA are episodes of oxyhemoglobin desaturations, which are terminated by brief periods of microarousals that could lead to sleep deprivation, fragmentation and alteration in sleep pattern [3] .…”

Section: Introductionmentioning

confidence: 99%

Chronic intermittent hypoxia-induced deficits in synaptic plasticity and neurocognitive functions: a role for brain-derived neurotrophic factor

Xie

Yung

2012

Acta Pharmacol Sin

View full text Add to dashboard Cite

Obstructive sleep apnea (OSA) is well known for its metabolic as well as neurobehavioral consequences. Chronic intermittent hypoxia (IH) is a major component of OSA. In recent years, substantial advances have been made in elucidating the cellular and molecular mechanisms underlying the effect of chronic IH on neurocognitive functions, many of which are based on studies in animal models. A number of hypotheses have been put forward to explain chronic IH-induced neurological dysfunctions. Among these, the roles of oxidative stress and apoptosis-related neural injury are widely accepted. Here, focusing on results derived from animal studies, we highlight a possible role of reduced expression of brain-derived neurotrophic factor (BDNF) in causing impairment in long-term synaptic plasticity and neurocognitive functions during chronic IH. The possible relationship between BDNF and previous findings on this subject will be elucidated.

show abstract

Section: Introductionmentioning

confidence: 99%

Chronic intermittent hypoxia-induced deficits in synaptic plasticity and neurocognitive functions: a role for brain-derived neurotrophic factor

Xie

Yung

2012

Acta Pharmacol Sin

View full text Add to dashboard Cite

show abstract

“…The studies which showed a significant delay in P300 latency had individuals with severe OSAS 13 , of sleep deprivation associated with forced awakeness 6 and because of their circadian cycle phase 17 . On the other hand, a study involving individuals with OSAS showed that the attention deficit is more severe in young people, when compared to elderly (threshold age: 50 years), and that age it does not interact with OSAS in worsening the cognitive deficit 26 .…”

Section: Discussionmentioning

confidence: 98%

Síndrome da apneia obstrutiva do sono e o potencial auditivo P300

Martins

Júnior²,

Filho

et al. 2011

Braz. j. otorhinolaryngol. (Impr.)

View full text Add to dashboard Cite

The obstructive sleep apnea syndrome (OSAS) reduces attention span, memory and concentration capacities, all associated with cognition. The analysis of the auditory P300 parameters could help infer cognitive dysfunction. Objective:To compare the data from polysomnography and the auditory P300 in adults, primary snorers with OSAS patients. Materials and Methods:Prospective study with primary snorers (N=12) and in OSAS patients (N=54), submitted to polysomnography, defined by the apnea-hypopnea index (AHI). The polysomnography and P300 variables were compared by the t-Student test, the Exact Fisher's Test, logistic regression and analysis of correlation with a significance level of 5%.Results: AIH had an inverse correlation with the oximetry in both groups. The P300 prevalence was lower in the OSAS group (Fisher's Exact Test, p=0.027). Patient age did not influence the P300 prevalence (regression analysis; p=0.232). The P300 amplitude was lower in the OSAS group (t-Student test; p=0.003) and the P300 latency was similar in both groups (t-Student test; p=0.89). Conclusion:The reduction in the P300 amplitude in patients with OSAS suggests cognitive dysfunction induced by a reduction in auditory memory. Braz J Otorhinolaryngol. 2011;77(6):700-5. ORIGINAL ARTICLE BJORL

show abstract

“…These breathing disruptions cause intermittent hypoxia and sleep disturbances which are associated with daytime sleepiness and fatigue 3 . The recurrent complete or partial obstruction of the upper airway causing intermittent hypoxia (IH) results in complete or partial airflow interruptions 4 . These episodes of oxygen denaturation are followed by alternate reoxygenation.…”

Section: Definitionmentioning

confidence: 99%

Sleep Apnea

Uzma

Reddy

2017

J. Gandaki Med. Coll. Nepal

View full text Add to dashboard Cite

Background: Sleep apnea is a condition that interrupts breathing while sleeping, usually caused by an obstruction blocking the back of the throat so that the air cannot reach the lungs. The brief cessation in breath automatically forces individuals to wake up and restart breathing. This can happen many times during the night, making it hard for the body to get enough oxygen, and impacts the sleep quality. It is the most common type of sleep disorder breathing.

show abstract

Effects of obstructive sleep apnea on cognitive function: A comparison between younger and older OSAS patients

Cited by 101 publications

References 42 publications

Chronic intermittent hypoxia-induced deficits in synaptic plasticity and neurocognitive functions: a role for brain-derived neurotrophic factor

Chronic intermittent hypoxia-induced deficits in synaptic plasticity and neurocognitive functions: a role for brain-derived neurotrophic factor

Síndrome da apneia obstrutiva do sono e o potencial auditivo P300

Sleep Apnea

Contact Info

Product

Resources

About