Abstract-One of the factors that causes of accidents due to the working risk on any production or business activities as well as Higher Education institutions is the human factor that more likely caused by the knowledge, attitudes and actions (behavior) of bad workers. There is still none data related to the implementation of occupational safety and health in the university environment that will be the main reason for the implementation of this study. The study started by identifying potential hazards that exist in the offices, classrooms and laboratory space in every department of the Faculty of Engineering in USU. The next step is to analyze the changes in the behavior of lecturer and employees by using t tests to see the extent of occupational safety and health training will affect lecturer and employee behavioral changing. From the results, the types of potential hazards are in the office, classroom and laboratory room is an electrical hazard of ergonomics danger, danger of noise, danger of falling, falling objects, thrown objects, and the scrap danger, mechanical danger, danger of fire and chemical hazard. From the t test results showed that the value of the probability p (0.000) <0.05. This means that there are significant differences on the knowledge, attitudes and their actions of the lecturer and staff before and after the occupational safety and health (K3) training. It is necessary to design Occupational Safety and Health engineering in form of safety signs and procedures book as information in an attempt to prevent the accidents. From the results, the type of potential hazards are in the office space is a danger of electrical amounted to 26% of all types of hazards, while the potential hazards in the classroom is the danger of noise by 22% of the total types of hazards and potential hazards in the laboratory is a danger of electrical amounted 19% of the total of danger. Results of hazard identification obtained will be the input for the engineering safety and health with creating signs and book procedures for Health and Safety (K3) as information in an effort to prevent accidents, and are advised to attend the training of occupational safety and health (K3).