Effects of oestrone and 2-methoxymethyl-17α-methyl-oestradiol-3-methyl ether (P-5780) on cholesterol metabolism in normo- and hypercholesterolaemic rats

Nakamura, Keiji; Masuda, Yuichi; Minaki, Yasuo

doi:10.1016/s0368-1319(68)80107-3

Cited by 2 publications

(2 citation statements)

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“…It was reported that lipid or cholesterol contents of the liver were increased in hyperlipidemic rats by treatment of some hypocholesteremic drugs, for example clofibrate or estrogens (Gould et al, 1966;Nakamura et al, 1968), though plasma cholesterol was markedly decreased. In the oxandrolone treated rats fed high cholesterol diet, cholesterol accumulation of the liver was more pronounced than in non-treated rats fed the high cholesterol diet.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore; Accumulation=influxed cholesterol-(outfluxed cholesterol+excreted cholesteterol as neutral sterols and bile acids) The increase of hepatic cholesterol by anabolic steroid is due to the fact that the former (influxed cholesterol) exceeds the latter (outfluxed cholesterol plus degradated cholesterol). It was suggested that the shift of cholesterol from plasma to liver was accelerated in estrogen treated rats but that the rate of degradation of cholesterol to bile acids was not significantly different from that found in the untreated rats (Boyd, 1963;Nakamura et al, 1968). When cholesterol is transferred to the liver too much to be degradated by the liver as in high cholesterol ingestion, the excessive amount of cholesterol has to be deposited in the tissue.…”

Section: Discussionmentioning

confidence: 99%

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Alteration of Cholesterol Metabolism Induced by Anabolic Steroid, Oxandrolone, Administration to Rats

et al. 1970

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SynopsisRemarkable lowering of plasma cholesterol by oxandrolone administration was observed in the hypercholesteremic rats fed the high cholesterol diet but not in the rats fed the low cholesterol diet during the short experimental period. Tween 80 induced hypercholesteremia or diabetic hypercholesteremia was not prevented by oxandrolone.Although the bile amount of the rats with bile fistulae was not influenced by the hormone administration, the biliary excretion of cholic acid and cholesterol was increased in the hormone treated group. Excretion of the radioactivity into the bile after labeled cholesterol injection was accelerated by oxandrolone. When 26-14C cholestereol was injected into the animals, more radioactivity was found in expiratory CO2 of the oxandrolone treated rats than that of the controls. Influx of administered cholesterol from plasma to the liver was accelerated in the oxandrolone fed rats with bile duct obstruction, and outflux of endogenous cholesterol from the liver to plasma was also increased.Cholesterol was accumulated in the liver by oxandrolone treatment when cholesterol was given simultaneously with the hormone, but the decrease of the hepatic cholesterol contents after the interruption of cholesterol feeding was promoted by the hormone administration.Therefore, the main mechanism of the hypocholesteremic effect of anabolic steroids is assumed to be both the acceleration of the shift of cholesterol from plasma to liver and secondary stimulation of cholesterol catabolism to bile acid.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%