Effects of Oil Palm (Elais guineensis) Fruit Extracts on Glucose Uptake Activity of Muscle, Adipose and Liver Cells

Abstract

The effect of oil palm (Elaeis guineensis) fruit aqueous extract (OPF) on glucose uptake activity of three different cell lines was investigated. The cell lines were incubated with different concentrations of OPF to evaluate the stimulatory effect of OPF towards glucose uptake activity of L6 myotubes, 3T3F442A adipocytes and Chang liver cell line. The glucose uptake activities of all tested cells were enhanced in the presence of OPF extract (basal condition). Nevertheless in combination of OPF extract and 100 nM insulin, the glucose uptake activity was only significantly enhanced in L6 myotubes and 3T3F442A adipocytes cell lines. The extracts enhanced the glucose uptake into cells through either insulin-mimetic or insulin-sensitizing property or combination of these two properties. It can be suggested that the OPF extract exerts its antihyperglycemic action partly by mediated glucose uptake into the glucose-responsive disposal cells, muscle, adipose and liver.

Inhibition of Digestive Enzyme and Stimulation of Human Liver Cells (HepG2) Glucose Uptake by Date Seeds Extract

“…GLUT4 and AMPK were related by a mechanical pathway starting with the activation of AMPK by polyphenols and resulting in the induction of GLUT4 transporters translocation [ 52 , 59 – 61 ]. The addition of insulin enhanced the effect of DSE on GLUT 4 level but not on AMPK level, which indicated that DSE could also translocate GLUT4 via the direct insulin-dependent mechanism, inducing the translocation of GLUT4 transporters [ 51 , 62 , 63 ]. AMPK is well-known to work as an energy sensor [ 64 , 65 ].…”