Effects of olanzapine, sertindole and clozapine on learning and memory in the Morris water maze test in naive and MK-801-treated mice

Mutlu, Oğuz; Ulak, Güner; Çelikyurt, İpek Komşuoğlu; Akar, Füruzan; Erden, Faruk

doi:10.1016/j.pbb.2011.02.009

Cited by 38 publications

(29 citation statements)

References 49 publications

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“…In previous researches, haloperidol and olanzapine disturbed cognitive function in MWM test in naïve mice (Mutlu et al, 2011;Xu et al, 2012), which is consistent with our results. However, PHA-543613 also performed negative effect on spatial learning and memory in naïve mice.…”

Section: Discussionsupporting

confidence: 93%

“…A previous study (Tyson, Roberts, & Mortimer, 2004) demonstrated that atypical antipsychotics acted on 5HT 2A receptors to lead the change of dopamine levels in the prefrontal cortex, which might elucidate the improvement of CIAS. However, in our study, olanzapine disturbed the spatial learning and memory in naïve which is consistent with a previous study (Mutlu et al, 2011). Ziprasidone had no influence on spatial learning and memory in naïve mice, meanwhile it reversed MK-801-induced cognitive impairment but olanzapine did not.…”

Section: Discussionsupporting

confidence: 93%

“…Hence, hippocampal-dependent spatial reference learning and memory was investigated. In our study, MK-801 increased the escape latency in acquisition phase as previously mentioned (Mutlu et al, 2011), and decreased the times of crossing the platform area in probe phase. Then, we first observed the influences of agents on spatial learning and memory in naïve mice, and the main finding was that haloperidol, olanzapine, and PHA-543613 impaired the performance in MWM test, increasing the mean escape latency in acquisition phase and decreasing the number of platform area crossings in probe test.…”

Section: Effects Of Haloperidol Olanzapine Ziprasidone and Pha-5supporting

confidence: 88%

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Effects of haloperidol, olanzapine, ziprasidone, and PHA‐543613 on spatial learning and memory in the Morris water maze test in naïve and MK‐801‐treated mice

et al. 2017

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Introduction Cognitive impairment is the core symptom of schizophrenia, significantly impacting the functional outcome. Improvement of cognitive function has been an important aspect of the treatment of schizophrenia. Therefore, this study is to demonstrate the effects of first‐generation antipsychotic haloperidol, second‐generation antipsychotic olanzapine and ziprasidone, and alpha‐7 nicotinic acetylcholine receptor agonist PHA ‐543613 on spatial learning and memory. Material and Methods C57 BL /6 mice received intraperitoneal injections of haloperidol (2 mg/kg), olanzapine (2.5 mg/kg), ziprasidone (2 mg/kg), and PHA ‐543613 (1 mg/kg), and cognitive dysfunctions were induced by MK ‐801 (0.1 mg/kg). Morris water maze was used for investigating the effects of all agents. Results Mk‐801 significantly increased the mean escape latency to the platform and decreased the number of platform area crossings. Ziprasidone had no effect on the mean escape latency to platform and the number of platform area crossings in naïve mice, but haloperidol, olanzapine, and PHA ‐543613 did not. Haloperidol and olanzapine significantly increased the mean escape latency to platform and decreased the number of platform area crossings, while ziprasidone and PHA ‐543613 did not. All the agents had no effect on swimming speed. Conclusions Ziprasidone and alpha‐7 nicotinic acetylcholine receptor agonist PHA ‐543613 might be helpful in the treatment of CIAS .

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 93%

Section: Effects Of Haloperidol Olanzapine Ziprasidone and Pha-5supporting

confidence: 88%

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Effects of haloperidol, olanzapine, ziprasidone, and PHA‐543613 on spatial learning and memory in the Morris water maze test in naïve and MK‐801‐treated mice

et al. 2017

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“…Time between injections was 10-12 min. The dose of CLZ was chosen from the literature owing to its ability to antagonize behavioral effects of NMDA-R antagonists (Bradford et al, 2010;Gleason and Shannon, 1997;Mutlu et al, 2011;Scorza et al, 2010;Yadav et al, 2011).…”

Section: Animals and Treatmentsmentioning

confidence: 99%

Clozapine Reverses Phencyclidine-Induced Desynchronization of Prefrontal Cortex through a 5-HT1A Receptor-Dependent Mechanism

Kargieman

Riga

Artigas

et al. 2011

Neuropsychopharmacol

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The non-competitive NMDA receptor (NMDA-R) antagonist phencyclidine (PCP)Fused as a pharmacological model of schizophreniaFdisrupts prefrontal cortex (PFC) activity. PCP markedly increased the discharge rate of pyramidal neurons and reduced slow cortical oscillations (SCO; 0.15-4 Hz) in rat PFC. Both effects were reversed by classical (haloperidol) and atypical (clozapine) antipsychotic drugs. Here we extended these observations to mice brain and examined the potential involvement of 5-HT 2A and 5-HT 1A receptors (5-HT 2A R and 5-HT 1A R, respectively) in the reversal by clozapine of PCP actions. Clozapine shows high in vitro affinity for 5-HT 2A R and behaves as partial agonist in vivo at 5-HT 1A R. We used wild-type (WT) mice and 5-HT 1A R and 5-HT 2A R knockout mice of the same background (C57BL/6) (KO-1A and KO-2A, respectively). Local field potentials (LFPs) were recorded in the PFC of WT, KO-1A, and KO-2A mice. PCP (10 mg/kg, intraperitoneally) reduced SCO equally in WT, KO-2A, and KO-1A mice (58 ± 4%, 42 ± 7%, and 63 ± 7% of pre-drug values, n ¼ 23, 13, 11, respectively; po0.0003). Clozapine (0.5 mg/kg, intraperitoneally) significantly reversed PCP effect in WT and KO-2A mice, but not in KO-1A mice nor in WT mice pretreated with the selective 5-HT 1A R antagonist WAY-100635.The PCP-induced disorganization of PFC activity does not appear to depend on serotonergic function. However, the lack of effect of clozapine in KO-1A mice and the prevention by WAY-100635 indicates that its therapeutic action involves 5-HT 1A R activation without the need to block 5-HT 2A R, as observed with clozapine-induced cortical dopamine release.

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“…Skarsfeldt (10) reported the impaired performance of rats in a water maze associated with haloperidol usage (10) and in a delayed non-matching to position test (8). According to previous studies, atypical antipsychotics offered greater efficacy for improving cognitive function when compared with typical antipsychotics; however, certain studies reported controversial effects from associated drugs (13)(14)(15). For example, administration of atypical antipsychotics, such as clozapine and olanzapine, more effectively attenuates the cognitive deficits in schizophrenic patients when compared with haloperidol administration (16).…”

Section: Discussionmentioning

confidence: 99%

Superior effects of quetiapine compared with aripiprazole and iloperidone on MK-801-induced olfactory memory impairment in female mice

Mutlu

Ulak

et al. 2017

Biomedical Reports

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Abstract.Cognitive dysfunction is commonly observed in schizophrenic patients and the administration of antipsychotic treatments results in different outcomes. Although the typical antipsychotic treatments, such as haloperidol, appear to be unable to improve cognition dysfunction, the atypical antipsychotic drugs (quetiapine, aripiprazole and iloperidone) exert a beneficial effect. The purpose of the current study was to investigate the effects of atypical antipsychotics on olfactory memory in mice, utilizing the social transmission of food preference (STFP) tests to evaluate the effects of drugs on MK-801-induced cognitive dysfunction. Female BALB/c mice were treated with quetiapine (5 and 10 mg/kg), aripiprazole (3 and 6 mg/kg), iloperidone (0.5 and 1 mg/kg) or MK-801 (0.1 mg/kg) alone or concurrently prior to retention sessions of STFP tests. In the STFP tests, quetiapine (10 mg/kg; P<0.05), aripiprazole (3 and 6 mg/kg; P<0.01 and P<0.001, respectively), iloperidone (0.5 and 1 mg/kg; P<0.01 and P<0.001, respectively) and MK-801 (P<0.001) significantly decreased cued/total food eaten (%). Quetiapine (5 mg/kg; P<0.05) significantly increased MK-801-induced decreases in cued/total food eaten (%), while aripiprazole and iloperidone demonstrated no significant effects. The results revealed that all of the drugs disturbed olfactory memory in the naive mice; however, only quetiapine reversed MK-801-induced memory impairment in the STFP test.

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Effects of olanzapine, sertindole and clozapine on learning and memory in the Morris water maze test in naive and MK-801-treated mice

Cited by 38 publications

References 49 publications

Effects of haloperidol, olanzapine, ziprasidone, and PHA‐543613 on spatial learning and memory in the Morris water maze test in naïve and MK‐801‐treated mice

Effects of haloperidol, olanzapine, ziprasidone, and PHA‐543613 on spatial learning and memory in the Morris water maze test in naïve and MK‐801‐treated mice

Clozapine Reverses Phencyclidine-Induced Desynchronization of Prefrontal Cortex through a 5-HT1A Receptor-Dependent Mechanism

Superior effects of quetiapine compared with aripiprazole and iloperidone on MK-801-induced olfactory memory impairment in female mice

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