Effects of olfactory function, age, and gender on trigeminally mediated sensations: a study based on the lateralization of chemosensory stimuli

Hummel, Thomas; Futschik, Thomas; Frasnelli, Johannes; Hüttenbrink, Karl-Bernd

doi:10.1016/s0378-4274(03)00078-x

Cited by 177 publications

(130 citation statements)

References 33 publications

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“…Subjects received 40 trials (20 deliveries of eucalyptol to each nostril) from which we calculated the percent of correct responses. This previously described method (Hummel et al, 2003;Dalton et al, 2006) is based on the well-established finding that although subjects have difficulty identifying the nostril receiving a purely olfactory stimulus, they can readily do this for stimuli with a trigeminal component (Cometto-Muñiz & Cain, 1998;Hummel et al, 2003;Wysocki et al, 2003;Dalton et al, 2006). The Tlaxcala subjects again performed significantly better than the Mexico City subjects (Fig.…”

Section: Trigeminal Sensitivitymentioning

confidence: 98%

Adverse Effect of Air Pollution on Odor Perception

Guarneros¹,

Drucker-Colı́n²,

Esquivelzeta³

et al. 2011

Advanced Topics in Environmental Health and Air Pollution Case Studies

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Section: Trigeminal Sensitivitymentioning

confidence: 98%

Adverse Effect of Air Pollution on Odor Perception

Guarneros¹,

Drucker-Colı́n²,

Esquivelzeta³

et al. 2011

Advanced Topics in Environmental Health and Air Pollution Case Studies

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“…10 In a first session, they had to press 2 squeeze-bottles at the same time by a hand-held squeezing device delivering either odor or no odor to the right or left nostril in a randomized sequence. Participants had to name the side of stimulation in a forced-choice procedure.…”

Section: Comparison With a Standard Odor Lateralization Taskmentioning

confidence: 99%

A Novel Device for the Clinical Assessment of Intranasal Trigeminal Sensitivity

Naka

Wolf

Renner

et al. 2014

Ann Otol Rhinol Laryngol

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Objective: Despite the significance of trigeminal pathology, practical clinical tests that accurately evaluate intranasal trigeminal function are scarce. The aim of the present study is to introduce a practical procedure for the assessment of intranasal trigeminal sensitivity. Methods: We developed a device to stimulate the nasal mucosa using carbon dioxide, which is self-administered intranasally by holding down a timed button until the required sensory response has been triggered. The trigeminal sensitivity is derived from the measured administration time in conjunction with the concentration of carbon dioxide administered. Sixty-three healthy participants were used to validate the device, after which the new device was compared with a standard lateralization task in an additional 16 participants. In 20 participants, the experiment was repeated to verify test-retest reliability. Results: Statistical analysis showed significant consistency in administration-duration in healthy individuals, including those in the test-retest group. Those participants with higher scores in the lateralization task were found to show higher intranasal sensitivity measured by the new device. Conclusion: Herein, we present the design and validation of a novel device for the practical assessment of intranasal trigeminal sensitivity. In this study, we demonstrate the efficacy and reliability of this device.

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“…Since the magnitude of the transient olfactory-induced EEG deflection is much smaller than the magnitude of the background EEG, the event is repeated several times and recorded responses are the added and averaged into a single waveform to increase the signal to noise ratio. The bulk of olfactory chemosensory event-related potentials consist of a negative component (N1) occurring between 320 and 450 ms after stimulus onset, followed by a positive (P2) component occurring between 530-800 ms (Hummel et al, 1992;Hummel et al, 2003;Kobal, 1999, 2002;Rombaux et al, 2006).…”

Section: Assessment Of Olfactory Functionmentioning

confidence: 99%