Effects of Olive Oil and Its Components on Intestinal Inflammation and Inflammatory Bowel Disease

Vrdoljak, Josip; Kumrić, Marko; Vilović, Marino; Martinović, Dinko; Tomić, Iris Jerončić; Krnić, Mladen; Kurir, Tina Tičinović; Božić, Joško

doi:10.3390/nu14040757

Cited by 25 publications

(23 citation statements)

References 81 publications

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“…However, it is worth bearing in mind that the content of extra olive oil's bioactive compounds can differ between olive oils due to the environmental conditions, extraction procedures, harvesting handlings and storage. Therefore, good-quality, non-refined olive oils stored in cold, dark places (as well as in dark bottles) should be recommended [228].…”

Section: Is the Mediterranean Diet An Alternative To The Western Diet...mentioning

confidence: 99%

Where Do We Stand in the Behavioral Pathogenesis of Inflammatory Bowel Disease? The Western Dietary Pattern and Microbiota—A Narrative Review

et al. 2022

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Despite the increasing knowledge with regard to IBD (inflammatory bowel disease), including ulcerative colitis (UC) and Crohn’s disease (CD), the etiology of these conditions is still not fully understood. Apart from immunological, environmental and nutritional factors, which have already been well documented, it is worthwhile to look at the possible impact of genetic factors, as well as the composition of the microbiota in patients suffering from IBD. New technologies in biochemistry allow to obtain information that can add to the current state of knowledge in IBD etiology.

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Section: Is the Mediterranean Diet An Alternative To The Western Diet...mentioning

confidence: 99%

Where Do We Stand in the Behavioral Pathogenesis of Inflammatory Bowel Disease? The Western Dietary Pattern and Microbiota—A Narrative Review

et al. 2022

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“…Yan et al 69 reported elevation of TBAR, IL-6, and INF-γ levels in colon tissue. These markers increase the inflammatory response of IL-6, INF-γ, NF-κB, destructive enzymes, and TBARs that cause damage to colon tissue 70 . In our study, CAPE significantly ameliorated tissue damage, IL-6, INF-γ, NF-κB, and TBARs in rats treated with DSS.…”

Section: Effect Of Cape and Sulfasalazine On Colonic Tbars Il-6 And I...mentioning

confidence: 99%

CAPE Improves Vanin-1/AKT/miRNA-203 Signaling Pathways in DSS-induced Ulcerative Colitis

et al. 2022

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Introduction: Ulcerative colitis (UC) and other inflammatory bowel diseases (IBDs) are common chronic, inflammatory gastrointestinal diseases. Due to their antioxidant, anti-inflammatory, and antibacterial properties, polyphenols are beneficial in the treatment of IBD. Caffeine acid phenethyl ester (CAPE) has been shown to have cytotoxic, antibacterial, antioxidant, and anti-inflammatory effects. This study focuses on the biochemical and molecular levels of the mode of action of CAPE in DSS-induced UC in rats. Methods: Thirty male Wistar rats were distributed into five groups, with six rats in each group: group I was administered 3 mL of distilled water orally, group II was administered CAPE (10 mg/kg.b.w.) orally, group III was administered 5% DSS orally, group IV was administered 5% DSS and CAPE (10 mg/kg.b.w.) orally; and group V was administered 5% DSS and sulfasalazine (100 mg/kg b.w.) orally. Results: Individually, oral treatment with CAPE or sulfasalazine significantly ameliorated body weight, DAI score, and colon length in DSS-induced colitis and raised blood PLT count, NO, NF-kβ , and vitamin C levels. In addition, animals given CAPE had a considerable increase in colon GSH, GPx, CAT, and SOD levels compared with rats given DSS. Compared with the DSS control group, colon TBAR, IL-6, and INF-γ were lower in the CAPE-treated rats. Histopathological examination revealed that CAPE treatment caused tissue injury and improved vanin-1, AKT, and miRNA-203 genes in the distal colon and triggered apoptosis. Conclusions: The gastroprotective impact of CAPE was more noticeable than sulfasalazine. CAPE treatment caused biochemical and histopathological improvements, indicating that CAPE may have antioxidant and anti-inflammatory effects in colitis; therefore, CAPE may be a potential therapeutic agent for the amelioration of IBD. This finding is promising for future therapies and research goals.

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“…Olive oil, which is extracted from its fruit, is the most characteristic nutrient in this diet [ 8 ]. The beneficial effect of olive oil on health is well-established [ 9 , 10 , 11 , 12 ]. The helpful aspects of olive oil have commonly been attributed to its minor components, such as polyphenols, α-tocopherol, and other unsaponifiable compounds [ 8 , 13 , 14 ], but little attention has been paid to oleic acid (OA) (18:1 n-9 cis-9).…”

Section: Introductionmentioning

confidence: 99%

Update on Anti-Inflammatory Molecular Mechanisms Induced by Oleic Acid

et al. 2023

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In 2010, the Mediterranean diet was recognized by UNESCO as an Intangible Cultural Heritage of Humanity. Olive oil is the most characteristic food of this diet due to its high nutraceutical value. The positive effects of olive oil have often been attributed to its minor components; however, its oleic acid (OA) content (70–80%) is responsible for its many health properties. OA is an effective biomolecule, although the mechanism by which OA mediates beneficial physiological effects is not fully understood. OA influences cell membrane fluidity, receptors, intracellular signaling pathways, and gene expression. OA may directly regulate both the synthesis and activities of antioxidant enzymes. The anti-inflammatory effect may be related to the inhibition of proinflammatory cytokines and the activation of anti-inflammatory ones. The best-characterized mechanism highlights OA as a natural activator of sirtuin 1 (SIRT1). Oleoylethanolamide (OEA), derived from OA, is an endogenous ligand of the peroxisome proliferator-activated receptor alpha (PPARα) nuclear receptor. OEA regulates dietary fat intake and energy homeostasis and has therefore been suggested to be a potential therapeutic agent for the treatment of obesity. OEA has anti-inflammatory and antioxidant effects. The beneficial effects of olive oil may be related to the actions of OEA. New evidence suggests that oleic acid may influence epigenetic mechanisms, opening a new avenue in the exploration of therapies based on these mechanisms. OA can exert beneficial anti-inflammatory effects by regulating microRNA expression. In this review, we examine the cellular reactions and intracellular processes triggered by OA in T cells, macrophages, and neutrophils in order to better understand the immune modulation exerted by OA.

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Effects of Olive Oil and Its Components on Intestinal Inflammation and Inflammatory Bowel Disease

Cited by 25 publications

References 81 publications

Where Do We Stand in the Behavioral Pathogenesis of Inflammatory Bowel Disease? The Western Dietary Pattern and Microbiota—A Narrative Review

Where Do We Stand in the Behavioral Pathogenesis of Inflammatory Bowel Disease? The Western Dietary Pattern and Microbiota—A Narrative Review

CAPE Improves Vanin-1/AKT/miRNA-203 Signaling Pathways in DSS-induced Ulcerative Colitis

Update on Anti-Inflammatory Molecular Mechanisms Induced by Oleic Acid

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