Effects of olopatadine hydrochloride, an antihistamine drug, on skin inflammation induced by repeated topical application of oxazolone in mice

Tamura, Tadafumi; Matsubara, Masahiro; Takada, Chie; Hasegawa, Kazuhide; Suzuki, Kazuo; Ohmori, Kenji; Karasawa, Akira

doi:10.1111/j.1365-2133.2004.06172.x

Cited by 33 publications

(34 citation statements)

References 33 publications

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“…In the present study, CA and AHAL significantly suppressed the ear edema and the increased level of IFN-g, a Th1 cytokine that activates various types of cells resulting in inflammatory events and the induction of skin hypertrophy due to an increase in keratinocyte proliferation. 35,36) In this context, a previous study described the antiproliferative activity of 12-acetoxy-hawtriwaic acid lactone on cell growth of human cell line, CCD922 normal skin fibroblasts. 37) In conclusion, we provided in vivo evidence to show that the diterpenes from Egletes viscosa are effective topical antiinflammatory agents in the experimental models of acute or chronic dermatitis and suggest that these may serve as lead compounds for developing drugs effective in skin inflammatory disorders like atopic or contact dermatitis and in psoriasis.…”

Section: Discussionmentioning

confidence: 99%

Topically Applied Diterpenoids from Egletes viscosa (Asteraceae) Attenuate the Dermal Inflammation in Mouse Ear Induced by Tetradecanoylphorbol 13-Acetate- and Oxazolone

Calou

Sousa

Andrade

et al. 2008

Biological & Pharmaceutical Bulletin

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Over the past three decades, the prevalence of atopic dermatitis and allergic or irritant contact dermatitis has been increasing significantly in the general population, causing considerable economic costs and decreased quality of life. [1][2][3] Topical corticosteroids have been the first-choice therapy for treatment of these inflammatory skin diseases such as eczema, atopic and seborrheic dermatitis, and psoriasis. While effective in many patients, this form of therapy carry the concern of local and systemic adverse effects and may induce skin atrophy, especially after long-term use. 4,5) In contrast to topical corticosteroids, the more recently introduced calcineurin inhibitors like tacrolimus and pimecrolimus do not induce skin atrophy, even after long-term use but may induce adverse effects such as burning, erythema and pruritus and are contraindicated in patients younger than two years or in those who are immunosuppressed.6,7) Thus, the available drugs, although have efficacy they are associated with adverse effects and therefore the development of new and safe anti-inflammatory topical agents for the treatment of dermatitis is needed.Studies reveal that a large percentage of patients use some form of complementary and alternative medicine for the treatment of atopic and contact dermatitis, which include herbal remedies. [8][9][10] In the recent past, several diterpene compounds of plant origin such as abietic acid from Pimenta racemosa var. grissea, hypoestoxide from Hypoestes rosea and marrubiin from Marrubium vulgare were shown to be effective in the mouse model of ear edema induced by several phlogestogens like histamine, bradykinin, capsaicin, prostaglandin E 2 , Croton oil, TPA (12-O-tetradecanoylphorbol 13-acetate) or oxazolone.11-13) Centipedic acid (CA) and 12-acetoxy-hawtriwaic acid lactone (AHAL, Tanabalin) are the naturally occurring diterpenes isolated from the aerial parts of Egletes viscosa L. (Asteraceae), a traditional medicinal plant.14) Previously we reported on the gastroprotective and antinociceptive properties of these diterpenes as well as an anti-edematogenic activity of tanabolin against ear edema induced by capsaicin. 15,16) However, the anti-inflammatory efficacy of these two diterpene compounds was not tested in the models of ear edema induced by either TPA or oxazolone, the most commonly used ones for analysing the agents effective against contact or atopic dermatitis.17,18) Thus as a part of our continuation study, we describe here for the first time the anti-dermatitis effects of these two natural diterpenes from Egletes viscosa using the experimental models of acute and chronic dermatitis induced by TPA and oxazolone, respectively, in the mouse ear. MATERIALS AND METHODS Plant Material and Isolation of DiterpenoidsThe aerial parts (2.5 kg) of Egletes viscosa LESS. (Asteraceae) were collected from the experimental plantation pertaining to the Department of Agronomy of this University, after its authentication and the voucher specimen (#16327) was retained in Prisco Bezerra He...

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Section: Discussionmentioning

confidence: 99%

Topically Applied Diterpenoids from Egletes viscosa (Asteraceae) Attenuate the Dermal Inflammation in Mouse Ear Induced by Tetradecanoylphorbol 13-Acetate- and Oxazolone

Calou

Sousa

Andrade

et al. 2008

Biological & Pharmaceutical Bulletin

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“…Histamine and H 1 receptor-mediated events have been found to play a key role in the development of eczematous lesions in experimental dermatitis in mice [24,28,33]. Seike et al [33 ]reported that histamine-deficient (histidine decarboxylase gene knockout) mice failed to develop diphenylcyclopropenone (DCP)-induced contact dermatitis, and this phenomenon was corrected by treatment with an H 1 receptor agonist.…”

Section: Discussionmentioning

confidence: 99%

“…Previous reports provided evidence for the pleiotropic effects of olopatadine: amelioration of the damaged skin barrier function [34], stabilization of mast cells [35], inhibition of monocyte migration [36], and improvement of inflammation and scratch behavior in oxazolone-evoked chronic dermatitis [28,29]. Of course, the therapeutic effects of olopatadine (reduced inflammatory cell infiltrates, cytokines and histamine) might result from the complex combination of these events.…”

Section: Discussionmentioning

confidence: 99%

“…An olopatadine nasal spray was recently launched for the treatment of nasal allergy symptoms [27]. It has been reported that olopatadine attenuates (1) the elevation of various inflammatory cytokines in skin lesions, and (2) the scratching behavior in a mouse model of chronic contact dermatitis induced by repeated hapten challenge [28,29]. Furthermore, olopatadine accelerates the recovery of skin barrier function [30].…”

Section: Introductionmentioning

confidence: 99%

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Olopatadine Hydrochloride Improves Dermatitis Score and Inhibits Scratch Behavior in NC/Nga Mice

Murota

El-latif²,

Tamura³

et al. 2010

Int Arch Allergy Immunol

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Background: Control of itch is an important issue in the treatment of atopic dermatitis (AD). Itch is mediated by a variety of pruritogens, including histamine, and promoted by neurite outgrowth in the epidermis of AD patients, probably due to the release of nerve growth factor. Objectives: We investigated the effects of orally administered olopatadine hydrochloride (olopatadine) on itching, itching mediators, and neuritogenic action in a mouse model. Materials and Methods: NC/Nga mice were treated topically with Dermatophagoides farinae body (Dfb) extract twice weekly for 4 weeks to induce AD-like lesions. They were concomitantly given oral olopatadine, distilled deionized water, or topical tacrolimus during the last 2 weeks. Results: Olopatadine significantly suppressed scratching, improved the dermatitis score, inhibited neurite outgrowth, and decreased the elevated inflammatory markers, growth factors and histamine content in the lesional skin, and serum concentration of Dfb-specific IgE. Notably, olopatadine treatment increased semaphorin 3A expression in the epidermis. Conclusions: Our study confirms the pleiotropic effects of olopatadine, i.e. inhibition of inflammation and neurite extension into the epidermis.

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“…Since most of these fi ndings are also observed in patients with AD, the mouse models appear to mimic many, if not all, events occurring within the lesioned skin of patients with AD. We recently have reported that olopatadine mitigates the cutaneous infl ammation in a mouse model of chronic infl ammatory dermatitis induced by repeated challenge of hapten to the ear [13] .…”

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confidence: 99%

Effect of Olopatadine and Other Histamine H<sub>1</sub> Receptor Antagonists on the Skin Inflammation Induced by Repeated Topical Application of Oxazolone in Mice

Tamura

Masaki²,

Ohmori³

et al. 2005

Pharmacology

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Histamine H₁ receptor antagonists have long been prescribed for atopic dermatitis as an adjuvant therapy with topical therapy by local applied steroids. Olopatadine is one of the second-generation histamine H₁ receptor antagonists that are treated for allergic disorders. We investigated that the effect of olopatadine on oxazolone-induced chronic contact hypersensitivity response in BALB/c mice compared with other histamine H₁ receptor antagonists loratadine, cetirizine and fexofenadine. The chronic contact hypersensitivity induced by repeated application of oxazolone was treated with olopatadine and other histamine H₁ receptor antagonists at the effective doses on histamine-induced paw edema in mice. The effects of these drugs in the oxazolone-induced model were quantified by measurements of ear swelling, and levels of cytokines in the lesioned ear. Olopatadine significantly inhibited the ear swelling and the increased production of IL-4, IL-1β, IL-6, GM-CSF and NGF in the lesioned ear. On the other hand, the other histamine H₁ receptor antagonists did not significantly suppress the increase in ear thickness. Moreover, they did not affect the production of cytokines in the lesioned ear. These results indicate that olopatadine appears to exert additional biological effects besides its blockade of the histamine H₁ receptor.

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Effects of olopatadine hydrochloride, an antihistamine drug, on skin inflammation induced by repeated topical application of oxazolone in mice

Abstract: These results indicate that olopatadine is an antihistamine agent having inhibitory activities against chronic inflammatory dermatitis, possibly resulting from its diminishing effect on elevated cytokines.

Cited by 33 publications

References 33 publications

Topically Applied Diterpenoids from Egletes viscosa (Asteraceae) Attenuate the Dermal Inflammation in Mouse Ear Induced by Tetradecanoylphorbol 13-Acetate- and Oxazolone

Topically Applied Diterpenoids from Egletes viscosa (Asteraceae) Attenuate the Dermal Inflammation in Mouse Ear Induced by Tetradecanoylphorbol 13-Acetate- and Oxazolone

Olopatadine Hydrochloride Improves Dermatitis Score and Inhibits Scratch Behavior in NC/Nga Mice

Effect of Olopatadine and Other Histamine H<sub>1</sub> Receptor Antagonists on the Skin Inflammation Induced by Repeated Topical Application of Oxazolone in Mice

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