Effects of omega-3 supplementation on anxiety-like behaviors and neuroinflammation in Wistar rats following cafeteria diet-induced obesity

González, Lucía Paola Facciola; Rodrigues, Fernanda da Silva; Jantsch, Jeferson; Fraga, Gabriel de Farias; Squizani, Samia; Castro, Luís Felipe dos Santos; Correia, Lidia Luz; Neto, João Coelho; Giovenardi, Márcia; Porawski, Marilene; Guedes, Renata Padilha

doi:10.1080/1028415x.2023.2168229

Cited by 8 publications

(3 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Additionally, chronic inflammation also characterizes the state of overweight or obesity, and the HFD consumption activates inflammatory pathways in peripheral tissues. This activation may potentially extend to the brain, affecting regions such as the hypothalamus, hippocampus, and cortex [ 37 , 41 , 42 , 43 ], and consequently induces behavior alterations [ 44 , 45 ]. In rodent models, it has been revealed that there is an increased anxiety-like behavior and symptoms resembling depression in response to HFD [ 17 , 46 , 47 , 48 ].…”

Section: Discussionmentioning

confidence: 99%

Effect of Probiotic Lacticaseibacillus rhamnosus LB1.5 on Anxiety-like Behavior, Neuroprotection and Neuroinflammation Markers of Male Mice Fed a High-Fat Diet

Schmidt,

Molz,

Fraga

et al. 2024

Nutrients

View full text Add to dashboard Cite

Probiotic supplementation has been identified as a potential target to reduce inflammatory mediators associated with obesity. Therefore, this study assessed the effect of probiotic Lacticaseibacillus rhamnosus LB1.5 on anxiety-like behavior, gene expression in the prefrontal cortex, and neuroinflammation in the cerebral cortex and hippocampus of male mice fed a high-fat diet. Mice aged 21 days were divided into four groups: control (CONT), control plus probiotic (CONT + PROB), high-fat diet (HFD), and high-fat diet plus probiotic (HFD + PROB), and fed for 13 weeks. The probiotic Lact. rhamnosus 1.5 (3.1 × 108 CFU/mL, derived from raw buffalo milk) was administered by gavage three times a week. Probiotic supplementation provided an anxiolytic effect in CONT and HFD. The IL-6 showed lower levels after probiotic supplementation in the HFD. Regarding immunoreactivity for GFAP in the cerebral cortex, we demonstrated that animals HFD-fed had a reduction in cells number compared to CONT. In the hippocampus, we found an interaction between diet and supplementation, as well as an effect of probiotic supplementation. A higher number of Th positive cells was observed in the cerebral cortex in mice fed HFD. Lact. rhamnosus LB1.5 supplementation decreased serum IL-6 levels in HFD-fed mice and promoted a reduction in anxiety-like behavior.

show abstract

Section: Discussionmentioning

confidence: 99%

Effect of Probiotic Lacticaseibacillus rhamnosus LB1.5 on Anxiety-like Behavior, Neuroprotection and Neuroinflammation Markers of Male Mice Fed a High-Fat Diet

Schmidt,

Molz,

Fraga

et al. 2024

Nutrients

View full text Add to dashboard Cite

show abstract

“…Dietary n-3 PUFA deficiency has been associated with several psychiatric disorders, which are manifested in adolescence, including mood and anxiety disorders (Jones et al, 2021; Mongan et al, 2021). This has led to numerous efforts to examine the impacts of n-3 PUFA supplementation on ameliorating the symptoms of these disorders (Bozzatello et al, 2021), which have yielded mixed results (Bove et al, 2018; González et al, 2024). Here, we employed a previously characterized animal model (Bondi et al, 2014) to investigate the effect of n-3 PUFA maternal deficiency and postweaning supplementation on different measures of anxiety and microglia morphology.…”

Section: Discussionmentioning

confidence: 99%

Impact of supplementation with omega-3 fatty acids after maternal dietary deficiency on adolescent anxiety and microglial morphology.

Bogachuk,

Jacobs,

Moghaddam

2024

Behavioral Neuroscience

View full text Add to dashboard Cite

Dietary maternal deficiency in omega-3 polyunsaturated fatty acids (n-3 PUFA) is a potential risk factor for the development of anxiety and other mood disorders in children and adolescents. Here, we used a previously characterized maternal n-3 PUFA dietary deficiency model in rats to determine the impact of postweaning supplementation on adolescent anxiety-like behaviors. We focused on two models of anxiety: innate anxiety tested by the elevated plus maze and a novel operant model of learned anxiety where animals learn that actions may be associated with a variable probability of harm. Given that recent basic and clinical studies have associated anxiety and other adverse effects of n-3 PUFA deficiency on inflammatory processes and microglial structure and function, we also assessed the impact of our dietary deficiency model and supplementation on adolescent microglial morphology in multiple brain regions. We found that the male and female adolescent n-3 PUFA-deficient groups exhibit increased innate anxiety, but only females showed enhanced learned anxiety. Supplementation after weaning did not significantly affect innate anxiety but ameliorated learned anxiety in females. Thus, the beneficial effects of supplementation on adolescent anxiety may be sex-specific and depend on the type of anxiety. We also found that n-3 PUFA deficiency influences microglia function in adolescents in the amygdala and nigrostriatal, but not mesolimbic, brain regions. Collectively, these data suggest that while n-3 PUFA dietary supplementation may be effective in reducing adolescent anxiety, this effect is context-, sex-, and brain network-specific.

show abstract

“…To determine the quality of fish oils, it is necessary to evaluate certain parameter such as iodine value (IV), acid index (AI), peroxide index (PI), anisidine index (IAn), thiobarbituric acid reactive substances (TBARS) and total oxidation index (TOTOX) [ 4 ] . Fish oils are rich in omega-3 polyunsaturated fatty acids, which help protect against cardiovascular diseases [ 5 ] . Minerals catalyze numerous metabolic reactions, maintain acid-base balance and are involved in the formation of bones, teeth, enzymes and hormones.…”

Section: Introductionmentioning

confidence: 99%

Assessment of cooking methods and freezing on the nutritional value and health risks of heavy metals in four fish species consumed in Douala, Cameroon

Jules Christophe,

Marlène,

Valery Jean François

et al. 2024

Heliyon

View full text Add to dashboard Cite

Effects of omega-3 supplementation on anxiety-like behaviors and neuroinflammation in Wistar rats following cafeteria diet-induced obesity

Cited by 8 publications

References 44 publications

Effect of Probiotic Lacticaseibacillus rhamnosus LB1.5 on Anxiety-like Behavior, Neuroprotection and Neuroinflammation Markers of Male Mice Fed a High-Fat Diet

Effect of Probiotic Lacticaseibacillus rhamnosus LB1.5 on Anxiety-like Behavior, Neuroprotection and Neuroinflammation Markers of Male Mice Fed a High-Fat Diet

Impact of supplementation with omega-3 fatty acids after maternal dietary deficiency on adolescent anxiety and microglial morphology.

Assessment of cooking methods and freezing on the nutritional value and health risks of heavy metals in four fish species consumed in Douala, Cameroon

Contact Info

Product

Resources

About