Effects of omeprazole on healing of non-steroidal anti-inflammatory drug (NSAID)-induced peptic ulceration in rats and protective role of indole-3-carbinol

Abstract

Gastric hyperacidity and gastroduodenal ulcer is a very common global problem today. It is now generally agreed that gastric lesions develop when the delicate balance between some gastroprotective and aggressive factors are lost. The objective of present study is to evaluate the effects of omeprazole on healing of non-steroidal anti-inflammatory drug (aspirin) induced peptic ulceration in adult male albino rats and gastroprotective role of indole-3-carbinol. Male albino rats were randomly divided into two main groups; control group administrated distilled water and ulcerated group administrated aspirin at a dose of 500 mg/kg/body weight for seven consecutive days. Aspirin administration was stopped after 7 days representing the initial duration for the experiment and was followed by the beginning of different experimental regimens for a total experimental duration of 26 days. Results of the present study showed that, groups treated with omeprazole alone accelerated ulcer healing by inhibiting gastric acid secretion but indole-3-carbinol (I3C) possessed protective activity possibly as evidenced by the reduction of histopathological alteration of stomach and duodenum tissues and inhibition of gastric acid secretion. This study provides a strong evidence of indole-3-carbinol which showed significant gastroprotective and antioxidant activities against aspirin induced peptic ulceration in male albino rats.