Effects of omeprazole or anti-reflux surgery on lower oesophageal sphincter characteristics and oesophageal acid exposure over 10 years

Emken, Birgitte-Elise Grinde; Lundell, Lars; Wallin, L; Myrvold, H. E.; Engström, Christer; Montgomery, Madeline C.; Malm, Anders; Lind, Tore; Hatlebakk, Jan Gunnar

doi:10.1080/00365521.2016.1224378

Cited by 9 publications

(6 citation statements)

References 36 publications

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“…Anti-reflux surgery is considered an effective treatment option for GERD and is widely performed in Western countries. Many clinical trials comparing anti-reflux surgery and PPI for GERD were conducted, and these trials found anti-reflux surgery as effective as or more effective than PPI at controlling GERD symptoms over a follow-up period of 5 years [87888990919293949596]. In addition, several studies among them demonstrated that anti-reflux surgery was likely to be cost-effective compared to medical treatment [909294].…”

Section: Resultsmentioning

confidence: 99%

Evidence-Based Practice Guideline for Surgical Treatment of Gastroesophageal Reflux Disease 2018

et al. 2018

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The prevalence of gastroesophageal reflux disease (GERD) is increasing in Korea, and physicians, including surgeons, have been focusing on its treatment. Indeed, in Korea, medical treatment using a proton pump inhibitor is the mainstream treatment for GERD, while awareness of surgical treatment is limited. Accordingly, to promote the understanding of surgical treatment for GERD, the Korean Anti-Reflux Surgery Study Group published the Evidence-Based Practice Guideline for the Surgical Treatment of GERD. The guideline consists of 2 sections: fundamental information such as the definition, symptoms, and diagnostic tools of GERD and a recommendation statement about its surgical treatment. The recommendations presented 5 debates regarding fundoplication: 1) comparison of the effectiveness of medical and surgical treatments, 2) effectiveness of surgical treatment in cases of refractory GERD, 3) effectiveness of surgical treatment of extraesophageal symptoms, 4) comparison of effectiveness between total and partial fundoplication, and 5) effectiveness of fundoplication in cases of hiatal hernia. The present guideline is the first to demonstrate the efficacy of the surgical treatment GERD in Korea.

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Section: Resultsmentioning

confidence: 99%

Evidence-Based Practice Guideline for Surgical Treatment of Gastroesophageal Reflux Disease 2018

et al. 2018

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“…These trials established that anti-reflux surgery is as effective as or more effective than PPI in controlling GERD symptoms over a follow-up period of 5 years. [250][251][252][253][254][255][256][257][258][259] Also, several studies demonstrated that anti-reflux surgery was likely to be cost-effective compared to medical treatment. 255,257,260 From the Statement 22: Anti-reflux surgery can be recommended as an alternative to proton pump inhibitor maintenance therapy to improve symptoms and quality of life in patients with proven gastroesophageal reflux disease.…”

Section: Anti-reflux Surgerymentioning

confidence: 99%

“…258 Moreover, several studies reported that anti-reflux surgery had a lower acid exposure of esophagus and higher pressure of LES than PPI treatment in short-term and long-term followup. 254,259,261 In terms of cost-effectiveness of the anti-reflux surgery, one study compared the cost-effectiveness of laparoscopic surgery (n = 155) and medical management (n = 104) using the data of a randomized multicenter trial. The results indicated that laparoscopic anti-reflux surgery is cost-effective, provided that its clinical benefits are sustained in the medium-to-long term.…”

Section: Anti-reflux Surgerymentioning

confidence: 99%

2020 Seoul Consensus on the Diagnosis and Management of Gastroesophageal Reflux Disease

Jung

Tae

Song

et al. 2021

J Neurogastroenterol Motil

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Based on a meta-analysis of 19 estimated acid-exposure time values in Asians, the reference range upper limit for esophageal acid exposure time was 3.2% (95% confidence interval, 2.7-3.9%) in the Asian countries. Esophageal manometry and novel impedance measurements, including mucosal impedance and a post-reflux swallow-induced peristaltic wave, are promising in discrimination of GERD among different reflux phenotypes, thus increasing its diagnostic yield. We also propose a long-term strategy of evidence-based GERD treatment with proton pump inhibitors and other drugs.

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“…At short and medium follow-up, surgical treatment is more effective than medical management [5]; on the other hand, open anti-reflux surgery or the use of proton pump inhibitors (PPIs) are both effective in normalizing reflux into the esophagus in a follow-up of 10 years. Lower esophageal sphincter pressure is repaired and maintained after fundoplication [6]. b.…”

Section: Related To Outcomes [2 4]mentioning

confidence: 99%

Perspectives of Surgery for Benign Esophageal Diseases

Cecconello¹,

Bernardo²

2017

Surgery for Benign Oesophageal Disorders

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Effects of omeprazole or anti-reflux surgery on lower oesophageal sphincter characteristics and oesophageal acid exposure over 10 years

Abstract: Open ARS and OME were both effective in normalising acid reflux into the oesophagus even when studied over a period of 10 years. Anatomically and functionally the LOS was repaired durably by surgery, with increased resting pressure and abdominal length.

Cited by 9 publications

References 36 publications

Evidence-Based Practice Guideline for Surgical Treatment of Gastroesophageal Reflux Disease 2018

Evidence-Based Practice Guideline for Surgical Treatment of Gastroesophageal Reflux Disease 2018

2020 Seoul Consensus on the Diagnosis and Management of Gastroesophageal Reflux Disease

Perspectives of Surgery for Benign Esophageal Diseases

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