Effects of ondansetron administration on opioid withdrawal syndrome observed in rats

Pinelli, A; Trivulzio, Silvio; Tomasoni, Livio

doi:10.1016/s0014-2999(97)01349-6

Cited by 33 publications

(25 citation statements)

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“…The results of the present study confirm an important functional interaction between the serotoninergic and opioid system [7][8][9][10][11][12][13] indicating that a large proportion of the contraction due to opioid withdrawal is caused by serotonin release since it can be blocked by methisergide, a serotonin receptor blocker.…”

Section: Discussionsupporting

confidence: 78%

“…The ability of methisergide to reduce opioid withdrawal confirm that serotonin plays an important role in expression of opiate withdrawal because serotonin agonist exacerbate opioid withdrawal; whereas, serotonin blockers attenuate some aspects of the syndrome [9][10][11][12][13]. ).…”

Section: Discussionmentioning

confidence: 99%

“…Manipulation that alter the activity of acetylcholine in the central nervous system (CNS) frequently modify the effects of morphine and other opioid drugs [7][8][9][10][11][12][13].…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, chronic administration of morphine to mice has been reported to increase turnover of 5-HT turnover in the brain thus confirming a strong link between serotoninergic and opioid system [7][8][9][10][11][12][13].…”

Section: Introductionmentioning

confidence: 94%

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Methisergide Selective Inhibition of Opioid Acute Physical Dependence in Isolated Tissues

Capasso

2008

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Dependence can be induced and measured in vitro by using guinea-pig ileum. Tissues from untreated animals, after a brief exposure to opioids, show a strong naloxone-induced contracture indicating that the cellular mechanisms of dependence may occur very rapidly following occupation of receptors and that these mechanisms operate within the myenteric plexus. The characteristics of dependence development and the precipitation of withdrawal by naloxone in the guinea-pig ileum are very similar to those of acute dependence in experimental animals and man. Several observations support the hypothesis that brain serotoninergic system has been widely implicated in many of the pharmacological effects of opioids. Manipulations that alter the activity of serotonin in the central nervous system (CNS) modify the effects of morphine. Furthermore, chronic administration of morphine to mice has been reported to increase turnover of 5-HT turnover in the brain thus confirming a strong link between serotoninergic and opioid system. Therefore, the effects exerted by methisergide, a blocker of serotonin receptor, on the acute opiate withdrawal was investigated in vitro. Following a 4 min in vitro exposure to the opioid agonist, the guinea-pig isolated ileum exhibited a strong contracture after the addition of naloxone (80% of contraction vs acetylcholine control). Methisergide (10 -7 -5x10 -7 -10 -6 M) treatment before or after the opioid agonists was able to respectively prevent or reverse the naloxone-induced contraction in isolated guinea pig ileum exposed to (morphine and DAMGO) opiate agonists in a concentration-dependent fascion whereas the k (U50-488H) opiate agonist significantly increased opiate withdrawal. The results of the present study confirm an important functional interaction between the serotoninergic and opioid system.

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Section: Discussionsupporting

confidence: 78%

Section: Discussionmentioning

confidence: 99%

“…Manipulation that alter the activity of acetylcholine in the central nervous system (CNS) frequently modify the effects of morphine and other opioid drugs [7][8][9][10][11][12][13].…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 94%

See 2 more Smart Citations

Methisergide Selective Inhibition of Opioid Acute Physical Dependence in Isolated Tissues

Capasso

2008

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“…Thus, they were observed after the first injection (Time 1), the second injection (Time 2) and the third injection (Time 3). The following signs were observed: urine by weighing the liquid content absorbed in the paper dishes after feces removal, feces excretion, by weighing stools on paper dishes (Pinelli et al, 1997) and global withdrawal score (GWS hereafter). The GWS was calculated by attributing one point when each of the following signs was present: bwet dog shakesQ, salivation, jumping, head lift, mastication, teeth chattering, abnormal posture, cheek tremors, sniffing, jumps, escape attempts, vocalization when touched.…”

Section: Methodsmentioning

confidence: 99%