Effects of one-time and two-time intra-articular injection of hyaluronic acid sodium salt after joint surgery in dogs

Nganvongpanit, Korakot; Boonsri, Burin; Sripratak, Thatdanai; Markmee, Patsanan

doi:10.4142/jvs.2013.14.2.215

Cited by 27 publications

(28 citation statements)

References 30 publications

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“…Separately, clinical gait scores were assessed using videography to record each animal as they were guided through a predetermined circuit before injection and during week 4 after injection. The animals were subsequently scored clinically according to a schema modified from the veterinary literature (25) (table S2). There was no abnormal gait observed in any of the animals before or after injection.…”

Section: Resultsmentioning

confidence: 99%

CT-guided injection of a TRPV1 agonist around dorsal root ganglia decreases pain transmission in swine

Brown

Saeed

et al. 2015

Sci. Transl. Med.

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One approach to analgesia is to block pain at the site of origin or along the peripheral pathway by selectively ablating pain-transmitting neurons or nerve terminals directly. The heat/capsaicin receptor (TRPV1) expressed by nociceptive neurons is a compelling target for selective interventional analgesia because it leaves somatosensory and proprioceptive neurons intact. Resiniferatoxin (RTX), like capsaicin, is a TRPV1 agonist but has greater potency. We combine RTX-mediated inactivation with the precision of computed tomography (CT)–guided delivery to ablate peripheral pain fibers in swine. Under CT guidance, RTX was delivered unilaterally around the lumbar dorsal root ganglia (DRG), and vehicle only was administered to the contralateral side. During a 4-week observation period, animals demonstrated delayed or absent withdrawal responses to infrared laser heat stimuli delivered to sensory dermatomes corresponding to DRG receiving RTX treatment. Motor function was unimpaired as assessed by disability scoring and gait analysis. In treated DRG, TRPV1 mRNA expression was reduced, as were nociceptive neuronal perikarya in ganglia and their nerve terminals in the ipsilateral dorsal horn. CT guidance to precisely deliver RTX to sites of peripheral pain transmission in swine may be an approach that could be tailored to block an array of clinical pain conditions in patients.

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Section: Resultsmentioning

confidence: 99%

CT-guided injection of a TRPV1 agonist around dorsal root ganglia decreases pain transmission in swine

Brown

Saeed

et al. 2015

Sci. Transl. Med.

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“…The HA dose administered was based on previous studies in dogs [20, 28]. There is no consensus in the current literature with respect to the required number of IA applications of HA to obtain satisfactory results.…”

Section: Discussionmentioning

confidence: 99%

“…Studies developed with humans have reported success with a single IA application [29, 30] and with multiple applications at weekly intervals [15, 31]. In dogs undergoing surgical correction of patellar luxation, a single IA application of HA at the end of surgery resulted in similar effects to the application of two doses at weekly intervals [20]. In humans, similar results were reported by Kolarz et al [32], who demonstrated that, in treatment with HA intra-articular injection, single or multiple applications resulted in similar beneficial effects in patients with signs of OA.…”

Section: Discussionmentioning

confidence: 99%

“…This finding may be attributed to the viscoelastic properties of HA, which act as a lubricant and shock absorber [13]. These effects are related to a reduction in sensitivity to mechanical forces of stretch-activated channels present in the membrane of joint mechanonociceptors [20]. …”

Section: Discussionmentioning

confidence: 99%

“…As body weight may influence the clinical response to treatment, this variable was measured monthly. The severity of clinical signs was measured by a single veterinarian (blinded to treatment allocation) using an ordinal scoring system (Table 1) which included pain on palpation, the ability to jump and climb stairs, lameness, and stiffness of movements [20, 21]. …”

Section: Methodsmentioning

confidence: 99%

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Intra‐Articular Hyaluronic Acid Compared to Traditional Conservative Treatment in Dogs with Osteoarthritis Associated with Hip Dysplasia

Carapeba

Cavaleti

Nicácio

et al. 2016

Evidence-Based Complementary and Alternative Medicine

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The purpose of this study was to compare the efficacy of the intra-articular (IA) hyaluronic acid injection to traditional conservative treatment (TCT) in dogs with osteoarthritis (OA) induced by hip dysplasia. Sixteen dogs were distributed into two groups: Hyal: IA injection of hyaluronic acid (5–10 mg), and Control: IA injection with saline solution (0.5–1.0 mL) in combination with a TCT using an oral nutraceutical (750–1000 mg every 12 h for 90 days) and carprofen (2.2 mg/kg every 12 h for 15 days). All dogs were assessed by a veterinarian on five occasions and the owner completed an assessment form (HCPI and CPBI) at the same time. The data were analyzed using unpaired t test, ANOVA, and Tukey's test (P < 0.05). Compared with baseline, lower scores were observed in both groups over the 90 days in the veterinarian evaluation, HCPI, and CPBI (P < 0.001). The Hyal group exhibited lower scores from 15 to 90 and 60 to 90 days, in the CBPI and in the veterinarian evaluation, respectively, compared to the Control group. Both treatments reduced the clinical signs associated with hip OA. However, more significant results were achieved with intra-articular hyaluronic acid injection.

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In vitro effects of triamcinolone acetonide and in combination with hyaluronan on canine normal and spontaneous osteoarthritis articular cartilage

Euppayo

Siengdee

Buddhachat

et al. 2016

In Vitro Cell.Dev.Biol.-Animal

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The purposes of this study were to examine the cartilage degradation effects of triamcinolone acetonide (TA) on normal and osteoarthritic (OA) primary canine chondrocytes and cartilage explants and to examine the cartilage degradation effects of TA in combination with low-molecular-weight hyaluronan (LMWHA). To assess the effects of these drugs on cell culture, 3,[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT) assay and real-time PCR were used to measure chondrotoxicity and determine gene expression, respectively. Uronic acid and hydroxyproline remaining in cartilage and histopathology were used to estimate the effects of these drugs on cartilage explants. In chondrocyte cultures, TA reduced chondrocyte viability in a concentration-dependent manner. LMWHA 2.5 mg/ml combined with TA at IC20 (0.09 mg/ml) could increase the viability of normal chondrocytes when compared with TA-treated alone. TA at IC20 induced down-regulation of ACAN and induced up-regulation of ADAMTS5 in canine normal chondrocytes. TA at IC20 (0.11 mg/ml) up-regulated ADAMTS5, MMP2, MMP3, MMP13, and ACAN expression in canine OA chondrocytes. In explant culture, TA at 1.25, 2.5, and 5 mg/ml increased the severity of structural damage, chondrocyte loss and cluster formation, and proteoglycan loss in OA cartilage. LMWHA could decrease the chondrotoxicity of TA at IC20 only in normal chondrocytes, as observed by chondrocyte viability. The combination of LMWHA and TA did not show clearly beneficial effects in all other normal and OA samples. Consequently, using TA alone or in combination with LMWHA in OA cartilage should be of concern because it may lead to cartilage destruction.

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Effects of one-time and two-time intra-articular injection of hyaluronic acid sodium salt after joint surgery in dogs

Cited by 27 publications

References 30 publications

CT-guided injection of a TRPV1 agonist around dorsal root ganglia decreases pain transmission in swine

CT-guided injection of a TRPV1 agonist around dorsal root ganglia decreases pain transmission in swine

Intra‐Articular Hyaluronic Acid Compared to Traditional Conservative Treatment in Dogs with Osteoarthritis Associated with Hip Dysplasia

In vitro effects of triamcinolone acetonide and in combination with hyaluronan on canine normal and spontaneous osteoarthritis articular cartilage

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