Effects of one-year once-weekly high-intensity interval training on body adiposity and liver fat in adults with central obesity: Study protocol for a randomized controlled trial

Chin, Edwin C.; Leung, Chit K.; Yu, Danny J.; Yu, Angus P.; Bernal, Joshua K.; Lai, Christopher; Chan, Derwin King Chung; Ngai, Heidi H.; Yung, Patrick Shu Hang; Lee, Chi H.; Fong, Daniel Yee Tak; Keating, Shelley E.; Coombes, Jeff S.; Siu, Parco M.

doi:10.1016/j.jesf.2022.03.003

Cited by 10 publications

(6 citation statements)

References 55 publications

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“…Intertuberous distance corresponded to the transverse distance between the lowest points of ischial tuberositie. Additionally, the mesorectal fat area (MFA) was measured at the level of the tip of the sciatic spine using Slice-O-matic software, version 4.3 (Tomovision, Montreal, QC, Canada) ( 19 ) ( Figure 2 ).…”

Section: Methodsmentioning

confidence: 99%

Nomogram for predicting the surgical difficulty of laparoscopic total mesorectal excision and exploring the technical advantages of robotic surgery

Guo,

Xia,

Wang

et al. 2024

Front. Oncol.

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BackgroundTotal mesorectal excision (TME), represents a key technique in radical surgery for rectal cancer. This study aimed to construct a preoperative nomogram for predicting the surgical difficulty of laparoscopic total mesorectal excision (L-TME) and to investigate whether there were potential benefits of robotic TME (R-TME) for patients with technically challenging rectal cancer.MethodsConsecutive midlow rectal cancer patients receiving total mesorectal excision were included. A preoperative nomogram to predict the surgical difficulty of L-TME was established and validated. Patients with technically challenging rectal cancer were screened by calculating the prediction score of the nomogram. Then patients with technically challenging rectal cancer who underwent different types of surgery, R-TME or L-TME, were analyzed for comparison.ResultsA total of 533 consecutive patients with midlow rectal cancer who underwent TME at a single tertiary medical center between January 2018 and January 2021 were retrospectively enrolled. Multivariable analysis demonstrated that mesorectal fat area, intertuberous distance, tumor size, and tumor height were independent risk factors for surgical difficulty. Subsequently, these variables were used to construct the nomogram model to predict the surgical difficulty of L-TME. The area under the receiver operating characteristic curve of the nomogram was 0.827 (95% CI 0.745 - 0.909) and 0.809 (95% CI 0.674- 0.944) in the training and validation cohort, respectively. For patients with technically challenging rectal cancer, R-TME was associated with a lower diverting ileostomy rate (p = 0.003), less estimated blood loss (p < 0.043), shorter procedure time (p = 0.009) and shorter postoperative hospital stay (p = 0.037).ConclusionIn this study, we established a preoperative nomogram to predict the surgical difficulty of L-TME. Furthermore, this study also indicated that R-TME has potential technical advantages for patients with technically challenging rectal cancer.

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Section: Methodsmentioning

confidence: 99%

Nomogram for predicting the surgical difficulty of laparoscopic total mesorectal excision and exploring the technical advantages of robotic surgery

Guo,

Xia,

Wang

et al. 2024

Front. Oncol.

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“…The CT images at the third lumbar vertebrae level were imported into slice Omatic 5.0 (Tomovision) medical imaging analysis software for body composition analysis (Fig. 2 ) 19 . Fat tissue was quantified by using recognized Hounsfield unit thresholds (− 190 to − 30 HU) 20 , 21 and the visceral fat area was measured after differentiation from the subcutaneous fat area.…”

Section: Methodsmentioning

confidence: 99%

Short-term outcome of intracorporeal ileocolonic anastomosis in patients with visceral obesity

Guo,

Xia,

Wang

et al. 2024

Sci Rep

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The primary objective of this study was to compare short-term outcomes between Intracorporeal ileocolic anastomosis (IIA) and extracorporeal ileocolic anastomosis (EIA) after laparoscopic right hemicolectomy in patients with visceral obesity. The secondary objective was to identify risk factors associated with prolonged postoperative ileus (PPOI) after laparoscopic right hemicolectomy. This single-center retrospective study analyzed visceral obesity patients who underwent laparoscopic right hemicolectomy for primary bowel cancer between January 2020 and June 2023. Patients were categorized into IIA and EIA groups based on the type of anastomosis, and a 1:1 propensity score-matched analysis was performed. A total of 129 patients were initially included in this study, with 45 patients in each group following propensity score matching. The IIA group had significantly longer anastomosis times (p < 0.001), shorter incision length (p < 0.001), and shorter length of stay (p = 0.003) than the EIA group. Meanwhile, the IIA group showed a shorter time to first flatus (p = 0.044) and quicker tolerance of a solid diet (p = 0.030). On multivariate analysis, postoperative use of opioid analgesics is an independent risk factor for PPOI (OR: 3.590 95% CI 1.033–12.477, p = 0.044), while IIA is an independent protective factor (OR: 0.195 95% CI 0.045–0.843, p = 0.029). IIA remains a safe and feasible option for visceral obesity patients. It is also associated with a quicker recovery of bowel function and shorter length of stay when compared to EIA. Additionally, IIA is an independent protective factor for PPOI.

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“…The distance between the intertuberous and interspinous was measured by CT. In addition, Slice-O-matic software (version 4.3, Tomovision, Montreal, QC, Canada) was employed for body composition analysis [ 14 ]. Visceral adipose tissue area (VAT) and skeletal muscle area (SMA) were measured at the third lumbar vertebra (L3) level on the CT image, and mesorectal fat area (MFA) was measured at the level of the tip of the ischial spine.…”

Section: Methodsmentioning

confidence: 99%

Nomogram for predicting prolonged postoperative ileus after laparoscopic low anterior resection for rectal cancer

Guo,

Sun,

Wang

et al. 2023

World J Surg Onc

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Background Prolonged postoperative ileus (PPOI) is a common complication after colorectal surgery that increases patient discomfort, hospital stay, and financial burden. However, predictive tools to assess the risk of PPOI in patients undergoing laparoscopic low anterior resection have not been developed. Thus, the purpose of this study was to develop a nomogram to predict PPOI after laparoscopic low anterior resection for rectal cancer. Methods A total of 548 consecutive patients who underwent laparoscopic low anterior resection for midlow rectal cancer at a single tertiary medical center were retrospectively enrolled between January 2019 and January 2023. Univariate and multivariate logistic regression analysis was performed to analyze potential predictors of PPOI. The nomogram was constructed using the filtered variables and internally verified by bootstrap resampling. Model performance was evaluated by receiver operating characteristic curve and calibration curve, and the clinical usefulness was evaluated by the decision curve. Results Among 548 consecutive patients, 72 patients (13.1%) presented with PPOI. Multivariate logistic analysis showed that advantage age, hypoalbuminemia, high surgical difficulty, and postoperative use of opioid analgesic were independent prognostic factors for PPOI. These variables were used to construct the nomogram model to predict PPOI. Internal validation, conducted through bootstrap resampling, confirmed the great discrimination of the nomogram with an area under the curve of 0.738 (95%CI 0.736–0.741). Conclusions We created a novel nomogram for predicting PPOI after laparoscopic low anterior resection. This nomogram can assist surgeons in identifying patients at a heightened risk of PPOI.

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Effects of one-year once-weekly high-intensity interval training on body adiposity and liver fat in adults with central obesity: Study protocol for a randomized controlled trial

Cited by 10 publications

References 55 publications

Nomogram for predicting the surgical difficulty of laparoscopic total mesorectal excision and exploring the technical advantages of robotic surgery

Nomogram for predicting the surgical difficulty of laparoscopic total mesorectal excision and exploring the technical advantages of robotic surgery

Short-term outcome of intracorporeal ileocolonic anastomosis in patients with visceral obesity

Nomogram for predicting prolonged postoperative ileus after laparoscopic low anterior resection for rectal cancer

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