Effects of Online Hemodiafiltration in Chronic Renal Failure Patients Treating With Maintenance Hemodialysis in Cho Ray Hospital

Abstract

Background: By combining diffisive and convective with a large volume in the same exchange method, Online Haemodiafiltration provide the highest clearances of both small and large solutes in the end stage renal disease patients who treated by maintenance hemodialysis. Objective: To investigate the serum levels of Ure, creatinin, phosphorus, Beta2-microglobulin and Homocystein before and after one session of Online Hemodiafiltration and one session of conventional Hemodialysis in the same patient. Method: Cross – sectional study. Results: 34 patients were treated by combining one session Online Hemodiafiltration and two sessions intermittent Hemodialysis/week. The urea reduction rate: 76.61 ± 7.37% Online Hemodiafiltration compare with 69.90 ± 7.55% conventional hemodialysis; the creatinin reduction rate: 67.76 ± 6.05% Online Hemodiafiltration compare with 61.40 ± 7.82% conventional hemodialysis; the phospho reduction rate: 52.37 ± 14.47% Online Hemodiafiltration compare with 42.81 ± 21.39% conventional hemodialysis; the Beta 2-microglobulin reduction rate: 72.42 ± 7.60% Online Hemodifiltration compare with 56.91 ± 12.76% conventional hemodialysis; the Homocysteine reduction rate: 43.23 ± 15.46% Online Hemodiafiltration compare with 33.68 ± 14.72% conventional hemodialysis. A differrent in two methods was significally and the solute reduction rate was higher with Online Hemodiafiltration, p < 0.01. Conclusion: Online Haemodiafiltration provide the highest clearances of both small and large solutes and helping to improve patient’s survival and quality of life.