It is necessary to study the seismic problem of buildings and structures for various safety reasons. Such as prevent and to reduce the damage caused by earthquakes to the greatest extent possible, research feasible analysis methods, and simulate the performance of the structure under earthquake action by computer, to keep its design performance in future earthquake action, and to ensure the safety of people's lives and property. The seismic design based on nonlinear vibration control is proposed. SAP2000 structure analysis software is used to establish the seismic structure model, foundation isolation model, and floor isolation model of a 15-story large chassis frame structure, the nonlinear time-history analysis of the three models under the action of multiple and rare earthquakes is carried out, and the period, displacement and acceleration of the isolated structure and the aseismatic structure are compared. The results show that, under the action of multiple earthquakes, the base shear of foundation isolation is 1208.06 kN, and the floor isolation is 926.43 kN, which are 0.37 and 0.3 of the base shears of the aseismatic structure, respectively. Under the action of rare earthquakes, the base-isolation shear is 4039.59 kN, and the story isolation shear is 3119.99 kN, which are, respectively, 0.4 and 0.31 of the base-isolation shears of the aseismatic structure. This method provides a reliable evaluation for nonlinear seismic response analysis of large complex high-rise buildings and provides an effective reference.