Effects of oral acrylamide intake on blood viscosity parameters in rats

Arıhan, Okan; Seringec, Nurten; Gurel, Esin Ileri; Dikmenoglu, Neslihan

doi:10.3233/ch-2010-1364

Cited by 21 publications

(8 citation statements)

References 37 publications

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“…which does not induce neurotoxicity alters blood viscosity. Increased blood viscosity means decreased fluidity of blood which might increase chances of cardiovascular disease [65]. A subsequent study evaluated the toxicity of ACR exposure in male F344 rats.…”

Section: Singh and Kushwahmentioning

confidence: 99%

Acrylamide: A Possible Risk Factor for Cardiac Health

Singh¹,

Kushwah²

2018

Asian J Pharm Clin Res

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Acrylamide (ACR) is an important industrial chemical agent also a food contaminant formed when food rich in carbohydrates is processed at high temperatures (120°C) such as cooking, frying, roasting, toasting, and baking. It happens when amino acid asparagine reacts with sugars, especially glucose and fructose as a result of the Maillard reaction. Its potential to cause damage to humans and animals makes it a cause for concern. After its outbreak in 2002, extensive study has been going on to prevent its formation in food. Neurological effects are by far well established for ACR along with systemic toxic effects. Diet contributes to the high proportion of ACR intake on daily basis; other exposure media are occupational, environmental, and smoking. A number of studies justifying ACR cardiotoxicity, its clear mechanism and its relevance to humans are less, but some research papers suggest the possibility of cardiotoxicity or developmental cardiotoxicity. In this review, ACR cardiac toxic effects and mechanism pathway have been discussed along with mitigation strategies.

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Section: Singh and Kushwahmentioning

confidence: 99%

Acrylamide: A Possible Risk Factor for Cardiac Health

Singh¹,

Kushwah²

2018

Asian J Pharm Clin Res

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“…The viscosity and resistance of the blood flow are decreased by erythrocyte deformability. This characteristic is especially significant during the transition across capillaries smaller than the diameter of erythrocytes (6). In contrast to the platelets, RBCs aggregate spontaneously.…”

Section: Introductionmentioning

confidence: 98%

Effects of Ankaferd Hemostat on red blood cell aggregation: a hemorheological study

Çiftçiler¹,

Aksu²,

FALKMARKEN³

2019

Turk J Med Sci

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Background/aim: Ankaferd hemostat (ABS; Ankaferd blood stopper, İstanbul, Turkey) is a prohemostatic agent affecting erythrocytes. The hemostatic action of ABS depends upon fibrinogen gamma chain, prothrombin, and red blood cells. The aim of this study was to assess the effects of ABS on erythrocyte aggregation via hemorheological analyses. Materials and methods: To measure erythrocyte aggregation, blood samples were obtained from healthy, nonsmoker volunteers who had not taken any medication in the previous 10 days. One mL of blood was placed into the laser-assisted optical rotational cell analyzer (LORCA), into the chamber formed by the gap between two concentric glass cylinders. The solution prepared with ABS and saline was added to blood in incremental amounts of 10 µL, 20 µL, 30 µL, 40 µL, 50 µL, 60 µL, 70 µL, and 100 µL. Erythrocyte aggregation was determined by laser-assisted optical rotational cell analyzer at 37 °C. Results: AMP was found to be 17.7 ± 2.1 au in the blood without ABS, whereas it was lower in the blood with ABS. AMP was 16.0 ± 3.3 in the ABS-added blood group. RBC aggregates did not form faster when cells contacted ABS. The t t½ value was 4.6 ± 2.6 in the ABS-added blood group and 1.9 ± 0.20 in the control group. Aggregation was faster in the control group (P = 0.03). AI, which is a combination of AMP and t½, was lowered in the ABS group (48.7 ± 12.3) compared to the control group (65.8 ± 1.6) (P = 0.02). It was notable that the γIsc max (sec-1) value of the control was higher (200 ± 106) than the ABS-added blood group (141 ± 51.0). Conclusion: ABS has antierythroid aggregation effect. ABS inhibits pathological aggregation of red blood cells. Antithrombotic clinical effects of ABS may be ascribed to the antierythroid aggregan actions of the drug.

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“…(Hashimoto and Aldridge., 1970). Polyacrylamides have various applications such as, paper strengthening, waste water treatment, production of biomedical and scientific enquiry materials like electrophoresis gels and personal care products such as lotions, cosmetics and deodorizers, hence a major source of occupational poisoning (Arihan et al, 2011). Acrylamide is also formed in foods that are rich in carbohydrates when they are cooked above 120C especially by the reaction of reducing sugars and amino acids like asparagine (Mottram et al, 2002;Stadler et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

Daily Use of Camellia Sinensis Extract Can Protect Acrylamide Induced Organ Pathologies in Mice

2021

THE JAPS

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Human beings are vulnerable to a variety of toxins. Nowadays concern has aroused to opt defensive mechanisms in the form of foodborne phytochemicals against these toxicants. Current research investigated the protective potential of green tea aqueous extract against Acrylamide (AA) induced organ toxicity. Eighty albino mice weighing (26±2g) divided equally into eight groups following CRD experimental mode. Three groups were orally exposed to various acrylamide concentrations (20g/g, 40g/g, 80g/g B.W of mice), other three were treated with respective doses of AA along with green tea extract for thirty days regularly. Control (without treatment) and GE (only green tea extract) groups were also maintained during current experiment. Blood and organs (liver, kidneys and testes) were extracted on euthanasia of the animals after 24hrs of last treatment, for serological and histopathological studies, respectively. Aqueous extract of Camellia sinensis was also assessed for total phenolic contents and antioxidant activity. The observations indicated that AA intoxication reduced testes weight, size, testosterone and ALP level while increased kidneys and liver size as well as ALT, bilirubin, creatinine and urea levels significantly (p≤0.05) as compared to control group. Histopathological anomalies in testicular, hepatic and renal tissues were also obvious in AA group. However, pathologies were much suppressed when green tea is co-administrated with acrylamide except for the highest concentration of acrylamide. It is deduced by above mentioned results that AA exposure is noxious in mice and green tea extract showed protective potential against its toxicity.

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Effects of oral acrylamide intake on blood viscosity parameters in rats

Cited by 21 publications

References 37 publications

Acrylamide: A Possible Risk Factor for Cardiac Health

Acrylamide: A Possible Risk Factor for Cardiac Health

Effects of Ankaferd Hemostat on red blood cell aggregation: a hemorheological study

Daily Use of Camellia Sinensis Extract Can Protect Acrylamide Induced Organ Pathologies in Mice

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